The effect of deferoxamine injection on composite graft survival in rabbits

Abstract

Background Composite graft as a reconstructive therapy option has limitations in size so that it is easily necrotic. Deferoxamine administration has been associated with increased neo-vascularity in wounds. We aimed to compare the administration of deferoxamine and Platelet-Rich Plasma (PRP) injection in a composite graft in rabbits. Methods Thirty New Zealand rabbits were divided into three groups; the control group, the deferoxamine group, and the PRP group. The composite graft with a diameter of 2 cm was taken and replanted after rotating it 180°. The mean graft viability and the mean number of capillaries were evaluated on day 7 (POD 7) by macroscopic and histological evaluation using Hematoxylin-Eosin staining. Results While the mean number of capillaries was not significantly different in control, deferoxamine, and PRP groups ( p = 0.21), the mean survival rate in the control, deferoxamine, and PRP groups reached a significant level with p -value of 0.006 (66.6% vs. 63.8% vs. 99.6%, respectively). Conclusions Deferoxamine group had the highest number of capillaries, but had the lowest survival rate. In the PRP group, it had the lowest number of capillaries, but had the highest survival rate.

Salvage of a nasal chondrocutaneous flap after a traumatic avulsion injury using a combination of treatments polydeoxyribonucleotide injection, continuous non-rebreather mask oxygen therapy, and chemical leeching: a case report

“…As neovascularization at the wound margin happens when aaps Archives of Aesthetic Plastic Surgery Sun H et al Salvage of nasal avulsion injury the endothelial cells are able to proliferate and migrate to the wound [4], a solid hematoma mechanically disturbing the close connection of the dermis layer can interrupt the neovascularization of the edge. Moreover, the cartilage of the nasal chondrocutaneous flap acts as a mechanical barrier that limits the perpendicular vascularity of the flap [5]. Thus, an accurate dermis connection to the wound margin dermis for horizontal neovascularization is particularly important for the viability of a nasal chondrocutaneous flap [5].…”

“…Moreover, the cartilage of the nasal chondrocutaneous flap acts as a mechanical barrier that limits the perpendicular vascularity of the flap [5]. Thus, an accurate dermis connection to the wound margin dermis for horizontal neovascularization is particularly important for the viability of a nasal chondrocutaneous flap [5].…”