The effect of daily consumption of probiotic yogurt on liver enzymes, steatosis and fibrosis in patients with nonalcoholic fatty liver disease (NAFLD): study protocol for a randomized clinical trial

Ebrahimi-Mousavi, Sara; Alavian, Seyed Moayed; Sohrabpour, Amir Ali; Dashti, Fatemeh; Djafarian, Kurosh; Esmaillzadeh, Ahmad

doi:10.1186/s12876-022-02176-2

Cited by 6 publications

(4 citation statements)

References 34 publications

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“… 97 , 98 Furthermore, daily consumption of probiotic rich foods, such as yogurt, had positive outcomes in patients with nonalcoholic fatty liver disease (NAFLD). 99 Along those lines, it is reasonable that probiotics treatment is beneficial for patients with PBC despite the lack of published evidence and warrants further study.…”

Section: Therapymentioning

confidence: 99%

Targeting Gut Microbiota for the Treatment of Primary Biliary Cholangitis: From Bench to Bedside

Zhang¹,

Yang²,

Chu³

2023

J Clin Transl Hepatol

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Primary biliary cholangitis (PBC) is a complex cholestatic liver disease with an unresolved etiology. The gut microbiota is composed of a dynamic community of bacteria, archaea, fungi, and viruses that have a key role in physiological processes related to nutrition, immunity, and host defense responses. A number of recent studies found that the composition of the gut microbiota of PBC patients was significantly altered, and reported that gut dysbiosis might arise during PBC development because of the close interactions of the liver and the gut. In light of the growing interest in this topic, the focus of this review is to characterize PBC gut microbiota alterations, the correlation between PBC pathology and the gut microbiota, and prospective therapies that target the altered gut microbiota, such as probiotics and fecal microbiota transplantation.

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Section: Therapymentioning

confidence: 99%

Targeting Gut Microbiota for the Treatment of Primary Biliary Cholangitis: From Bench to Bedside

Zhang¹,

Yang²,

Chu³

2023

J Clin Transl Hepatol

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“…These are due in part to the restrictions of small sample sizes, dosage and strain heterogeneity, and differences in intervention duration. Furthermore, few studies have investigated the connection between probiotic foods that people regularly intake (rather than as supplements) and HS ( 16 ). Mendelian randomization (MR) is a statistical method for making causal conclusions in epidemiology etiology.…”

Section: Introductionmentioning

confidence: 99%

“…Metabolic disorders, caused by intestinal microbial dysregulation, also played an important role in the pathogenesis of MAFLD (12,13). Although there have been systematic reviews on the use of probiotics and prebiotics in the treatment and prevention of MAFLD, the evidence currently available is insufficient to decisively establish the benefits of probiotics on HS (14,15). These are due in part to the restrictions of small sample sizes, dosage and strain heterogeneity, and differences in intervention duration.…”

Section: Introductionmentioning

confidence: 99%

Probiotic consumption and hepatic steatosis: results from the NHANES 2011–2016 and Mendelian randomization study

Song,

Guo,

Wang

et al. 2024

Front. Nutr.

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BackgroundRecent research showed that probiotics treatment may reduce insulin resistance, regulate lipid metabolism, raise liver enzyme levels, and ameliorate inflammation in individuals with metabolic associated fatty liver disease (MAFLD). However, the possible effects of probiotic use on the progression of hepatic steatosis (HS) have not been identified. The purpose of this study was to investigate this in a large population database.MethodsThe cross-sectional research was conducted among adults with complete data on probiotic yogurt consumption and HS in the 2011–2016 National Health and Nutrition Examination Survey (NHANES). Probiotic yogurt consumption was assessed using a dietary supplement questionnaire, while HS was evaluated with HS index (HSI). To explore their relationship, weighted univariate regression analysis, subgroup analysis, and interaction analysis were conducted. To evaluate the causal association between yogurt consumption and NAFLD, mendelian randomization analysis (MR) were performed. A restricted cubic spline (RCS) was used to analyze the relationship curve between the leves of yogurt consumption and hepatic steatosis.ResultsA total of 7,891 participants were included in the study represented 146.7 million non-institutionalized residents of the United States, of whom 4,322 (54.77%) were diagnosed with HS. Multivariable logistic regression showed probiotic yogurt consumption had significantly inverse relationship for HS (OR = 0.84, 95% CI: 0.72–0.97, p = 0.02) after adjusting for all covariates. Once more, the independent relationship between probiotic yogurt consumption and HS was verified by subgroup analysis and interaction analysis. The MR analysis results indicate that there is no causal relationship between yogurt consumption and NAFLD. The RCS model demonstrated a robust J-shaped link between yogurt consumption and HS, revealing a significant decrease in risk within the lower range of yogurt consumption, which attained the lowest risk close to 0.4 cup.ConclusionAccording to the NHANES data, the consumption of probiotics and yogurt has a beneficial effect on HS, whereas the MR results indicated it was not related to NAFLD. The RCS analysis indicates a J-shaped relationship between yogurt consumption and HS, which may account for the inconsistency in the results. Based on these findings, we recommend that adults take half a cup of yogurt daily.

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“…Therefore, there is no pharmacological therapy for NAFLD. It is obvious that lifestyle modification including diet and exercise are golden keys to fatty liver managements [ 7 8 9 10 ]. Regardless of calorie-related aspects of diet and its correlation with weight control, studies have less addressed the effects of dietary composition on liver health [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Association Between Protein Intake From Different Animal and Plant Origins and the Risk of Non-Alcoholic Fatty Liver Disease: A Case-Control Study

et al. 2023

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Previous studies have frequently reviewed how different macronutrients affect liver health. Still, no study centered around protein intake and the non-alcoholic fatty liver disease (NAFLD) risk relationship. This study aimed to examine the association between the consumption of total and different sources of protein and NAFLD risk. We allocated 243 eligible subjects to the case and control groups, including 121 incidence cases of NAFLD, and 122 healthy controls. Two groups were matched in age, body mass index, and sex. We evaluated the usual food intake of participants using FFQ. Binary logistic regression was conducted to estimate the risk of NAFLD in relation to different sources of protein intake. The age of participants was 42.7 years on average, and 53.1% were male. We found Higher intake of protein in total (odds ratio [OR], 0.24; 95% confidence interval [CI], 0.11–0.52) was significantly associated with a lower risk of NAFLD, despite adjusting for multiple confounders. in detail, higher tendency to the vegetables (OR, 0.28; 95% CI, 0.13–0.59), grains (OR, 0.24; 95% CI, 0.11–0.52), and nuts (OR, 0.25; 95% CI, 0.12–0.52) as the main sources of protein, were remarkably correlated with lower NAFLD risk. In contrary, increased intake of meat protein (OR, 3.15; 95% CI, 1.46–6.81) was positively associated with a higher risk. Totally, more calorie intake from proteins was inversely associated with lower NAFLD risk. This was more likely when the protein sources were selected less from meats and more from plants. Accordingly, increasing the consumption of proteins, particularly from plants, may be a good recommendation to manage and prevent NAFLD.

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The effect of daily consumption of probiotic yogurt on liver enzymes, steatosis and fibrosis in patients with nonalcoholic fatty liver disease (NAFLD): study protocol for a randomized clinical trial

Cited by 6 publications

References 34 publications

Targeting Gut Microbiota for the Treatment of Primary Biliary Cholangitis: From Bench to Bedside

Targeting Gut Microbiota for the Treatment of Primary Biliary Cholangitis: From Bench to Bedside

Probiotic consumption and hepatic steatosis: results from the NHANES 2011–2016 and Mendelian randomization study

Association Between Protein Intake From Different Animal and Plant Origins and the Risk of Non-Alcoholic Fatty Liver Disease: A Case-Control Study

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