Abstract:The effect of the immunomodulatory fungal metabolite cyclosporin A (CyA) on the course ofParagonimus miyazakiiinfection in rats was studied. Administration of CyA 15 to 19 days post-infection resulted in a significantly lower recovery rate of worms and cyst formation in the host's lungs than in controls. Administration of CyA − 1 to + 3 days post-infection enhanced the growth and maturation ofP. miyazakii, expressed as weight of worms and the number of worms with eggs in uteri with respect to control values. T… Show more
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