The effect of cyclosporin A on Angiostrongylus cantonensis infection and eosinophilia in mice

Yoshimura, Kazuya; Sugaya, Hiroko; Ishida, Kazuhiko; Khan, Waliul I.; Abé, Tatsuya; Unno, Katsuo

doi:10.1016/0020-7519(93)90119-j

Cited by 4 publications

(2 citation statements)

References 25 publications

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“…Cyclosporine was helpful in a mouse model of NA [92]. The benefits appear to be twofold: i) its effect on T cells reduces the host's immune response, particularly eosinophil recruitment and ii) it has a direct anti-parasitic effect.…”

Section: Discussionmentioning

confidence: 99%

Twenty two cases of canine neural angiostrongylosis in eastern Australia (2002-2005) and a review of the literature

Lee

Smaller

et al. 2012

Parasites Vectors

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Cases of canine neural angiostrongylosis (NA) with cerebrospinal fluid (CSF) evaluations in the peer-reviewed literature were tabulated. All cases were from Australia. A retrospective cohort of 59 dogs was contrasted with a series of 22 new cases where NA was diagnosed by the presence of both eosinophilic pleocytosis and anti- Angiostrongylus cantonensis immunloglobulins (IgG) in CSF, determined by ELISA or Western blot. Both cohorts were drawn from south east Queensland and Sydney. The retrospective cohort comprised mostly pups presented for hind limb weakness with hyperaesthesia, a mixture of upper motor neurone (UMN) and lower motor neurone (LMN) signs in the hind limbs and urinary incontinence. Signs were attributed to larval migration through peripheral nerves, nerve roots, spinal cord and brain associated with an ascending eosinophilic meningo-encephomyelitis. The contemporary cohort consisted of a mixture of pups, young adult and mature dogs, with a wider range of signs including (i) paraparesis/proprioceptive ataxia (ii) lumbar and tail base hyperaesthesia, (iii) multi-focal central nervous system dysfunction, or (iv) focal disease with neck pain, cranial neuropathy and altered mentation. Cases were seen throughout the year, most between April and July (inclusive). There was a preponderance of large breeds. Often littermates, or multiple animals from the same kennel, were affected simultaneously or sequentially. A presumptive diagnosis was based on consistent signs, proximity to rats, ingestion/chewing of slugs or snails and eosinophilic pleocytosis. NA was diagnosed by demonstrating anti- A. cantonensis IgG in CSF. Detecting anti- A. cantonensis IgG in serum was unhelpful because many normal dogs (20/21 pound dogs; 8/22 of a hospital population) had such antibodies, often at substantial titres. Most NA cases in the contemporary series (19/22) and many pups (16/38) in the retrospective cohort were managed successfully using high doses of prednisolone and opioids. Treatment often included antibiotics administered in case protozoan encephalomyelitis or translocated bacterial meningitis was present. Supportive measures included bladder care and physiotherapy. Several dogs were left with permanent neural deficits. Dogs are an important sentinel species for NA. Human cases and numerous cases in tawny frogmouths were reported from the same regions as affected dogs over the study period. Electronic supplementary material The online version of this article (doi:10.1186/1756-3305-5-70) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Twenty two cases of canine neural angiostrongylosis in eastern Australia (2002-2005) and a review of the literature

Lee

Smaller

et al. 2012

Parasites Vectors

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“…The fungal metabolite cyclosporin A (CsA) has been used as a tool of investigating cellular immune mechanisms in various parasitic infections 52 . YOSHIMURA et al 55 tried to determine the possible effects of cyclosporin A (CsA) on Angiostrongylus cantonensis infection and eosinophilia in mice. The data indicated a direct damaging activity of CsA against certain developmental stages of the parasite.…”

Section: Chemotherapy and Immune Status Of The Hostmentioning

confidence: 99%

Drug trials for treatment of human angiostrongyliasis

Mentz

Graeff-Teixeira

2003

Rev. Inst. Med. trop. S. Paulo

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Abdominal and cerebral angiostrongyliasis are two important infections produced by metastrongylid worms, the former occurring in Central and South America and the later in Asia and Pacific Islands. Drug treatment is a challenge since the worms and its evolving larvae live or migrate inside vessels and efficient killing of the parasites may produce more severe lesions. Larvicidal effect of certain drugs appears to be more easily accomplished but this outcome is not useful in abdominal angiostrongyliasis since clinical manifestations appear to result from sexual maturation of the worms. We review the drug trials in murine experimental models and conclude that most of them could not be considered good candidates for treatment of human infection, except for PF1022A, pyrantel and flubendazole.

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