The effect of curcumin on healing in an animal nasal septal perforation model

Abstract

Objectives/Hypothesis We investigated the effect of intranasal topical curcumin on nasal septum mucosa wound healing in a nasal septal perforation model produced in rabbits. Study Design Experimental study. Methods Fourteen male New Zealand rabbits were included in the study. For each rabbit, 5‐mm‐diameter circular perforations were created at 5 mm away from the columella to the nasal septum. Curcumin (study group) and saline (control group) were administered intranasally once daily for 10 days. At the end of the 10th day, the animals were sacrificed and the nasal septum specimens were sent for histological examination. Epithelial regeneration and degeneration, cartilage degeneration and regeneration, presences of fibroblast, eosinophil, acute/chronic inflammatory and giant cells, capillary density, amounts of granulation tissue and collagen, and macroscopic closure rate of perforation parameters were compared in each group. Results Epithelial and cartilage regeneration, and the amounts of collagen and granulation tissue were significantly higher in the curcumin group compared to the control group (P < .05). No statistically significant difference was found in comparison of other parameters (P > .05). Conclusions Topical application of curcumin improves the wound‐healing process of nasal septum perforation in the animal model. Therefore, curcumin can be used as a safe and effective medical agent to prevent the development of septal perforation. Level of Evidence NA Laryngoscope, 129:E349–E354, 2019

The Effect of Locally Delivered Apocynin on Fat Graft Survival in an Experimental Rat Animal Model

“…31 Accordingly, a recipient site with increasing vascularity and subsiding oxidative stress and inflammation reactions would positively affect fat grafting outcomes by reducing cell death by apoptosis as in a conventional wound healing setting. [39][40][41] Therefore, it has been speculated that anti-oxidant and anti-apoptotic molecules play a critical role in either induction or maintenance of pro-healing microenvironment capable of reducing the resorption of the graft. In a search of clinically effective substances with minimal side effects, the compounds such as acetylcysteine, DMSO, coenzyme Q10, niacin B3, and curcumin have been used to prevent fat graft resorption with varying outcomes.…”

“…Accordingly, a recipient site with an increasing vascularity and subsiding oxidative stress and inflammation reactions, would positively affect fat grafting outcomes by reducing cell death by apoptosis as in conventional wound healing setting [39][40][41] . Therefore, it has been speculated that anti-oxidant and anti-apoptotic molecules play a critical role in either induction or maintenance of pro-healing microenvironment capable of reducing the resorption of the graft.…”

The Effect of Melatonin on Nasal Septal Wound Healing in an Experimental Animal Model

“…NSP usually occurs during or after surgery where septal cartilage or bone is removed and mucosal tears are created at both sides of the corresponding area (6). In cases where the mucoperiosteal flaps cannot recover spontaneously to cover the perforation, the borders of NSP are healed with an atrophic mucosa, which may predispose to persistent perforation (7). Therefore, the wound healing process plays an important role in the formation of NSP.…”

“…Many types of molecules and cells play a role in wound healing, and many factors can accelerate or prolong this process. An optimal wound healing accelerating agent should reduce inflammation, act as an antioxidant, induce cell proliferation, and protect tissue from infections (7,8).…”

“…Acute inflammatory cells number, degeneration and regeneration of nasal septal epithelium, degeneration and regeneration of the septal cartilage, fibroblast number, capillary vessel intensity, granulation formation, collagen intensity, eosinophil count, giant cell number were evaluated histopathologically. The histopathological parameters were scored by dividing them into four grades (0: None, 1: Mild, 2: Moderate, 3: Intensive) (7). The histopathological parameter scores were determined as the mean of the scores made by both pathologists.…”