The Effect of Curcumin on the Gut-Brain Axis: Therapeutic Implications

Enayati, Ayesheh; Soghi, Aida; Butler, Alexandra E; Rizzo, Manfredi; Sahebkar, Amirhossein

doi:10.5056/jnm23065

Cited by 3 publications

(2 citation statements)

References 48 publications

(127 reference statements)

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“…The interplay between microbiota and curcumin and the generated metabolites is thought to promote a healthy condition in the human body that goes far beyond the direct effects at the intestinal epithelium [ 89 , 90 ]. Curcumin can positively alter microbial diversity and enrich mostly beneficial bacterial strains, leading to improved intestinal barrier function and less inflammation [ 90 , 91 ].…”

Section: Curcumin and Curcuminoidsmentioning

confidence: 99%

Enhancing the Bioavailability and Bioactivity of Curcumin for Disease Prevention and Treatment

Bertoncini-Silva,

Vlad,

Ricciarelli

et al. 2024

Antioxidants

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Curcumin, a natural polyphenolic component from Curcuma longa roots, is the main bioactive component of turmeric spice and has gained increasing interest due to its proposed anti-cancer, anti-obesity, anti-inflammatory, antioxidant, and lipid-lowering effects, in addition to its thermogenic capacity. While intake from dietary sources such as curry may be sufficient to affect the intestinal microbiome and thus may act indirectly, intact curcumin in the body may be too low (<1 microM) and not sufficient to affect signaling and gene expression, as observed in vitro with cultured cells (10–20 microM). Several strategies can be envisioned to increase curcumin levels in the body, such as decreasing its metabolism or increasing absorption through the formation of nanoparticles. However, since high curcumin levels could also lead to undesired regulatory effects on cellular signaling and gene expression, such studies may need to be carefully monitored. Here, we review the bioavailability of curcumin and to what extent increasing curcumin levels using nanoformulations may increase the bioavailability and bioactivity of curcumin and its metabolites. This enhancement could potentially amplify the disease-preventing effects of curcumin, often by leveraging its robust antioxidant properties.

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Section: Curcumin and Curcuminoidsmentioning

confidence: 99%

Enhancing the Bioavailability and Bioactivity of Curcumin for Disease Prevention and Treatment

Bertoncini-Silva,

Vlad,

Ricciarelli

et al. 2024

Antioxidants

View full text Add to dashboard Cite

show abstract

“…The GBA involves two-way communication between the central nervous system (CNS) and the enteric nervous system (ENS), connecting the emotional and cognitive areas of the brain to the functions of the GI tract [ 8 ]. A functional GBA is required for regulation of digestion, nutrient absorption, and normal functioning of the gut; the dysregulation of this axis in IBD adds another layer of complexity in the pathophysiology of this disease that needs to be addressed to reduce the incidence of mental disorders in these patients [ 9 , 10 ]. Moreover, IBD-mediated changes in the ENS could alter bi-directional communication through the GBA [ 11 ], potentially exacerbating gut symptoms in individuals with IBD.…”

Section: Introductionmentioning

confidence: 99%

Enteric Nervous System Alterations in Inflammatory Bowel Disease: Perspectives and Implications

Suman

2024

Gastrointestinal Disorders

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The enteric nervous system (ENS), consisting of neurons and glial cells, is situated along the gastrointestinal (GI) tract’s wall and plays a crucial role in coordinating digestive processes. Recent research suggests that the optimal functioning of the GI system relies on intricate connections between the ENS, the intestinal epithelium, the immune system, the intestinal microbiome, and the central nervous system (CNS). Inflammatory bowel disease (IBD) encompasses a group of chronic inflammatory disorders, such as Crohn’s disease (CD) and ulcerative colitis (UC), characterized by recurring inflammation and damage to the GI tract. This review explores emerging research in the dynamic field of IBD and sheds light on the potential role of ENS alterations in both the etiology and management of IBD. Specifically, we delve into IBD-induced enteric glial cell (EGC) activation and its implications for persistent enteric gliosis, elucidating how this activation disrupts GI function through alterations in the gut–brain axis (GBA). Additionally, we examine IBD-associated ENS alterations, focusing on EGC senescence and the acquisition of the senescence-associated secretory phenotype (SASP). We highlight the pivotal role of these changes in persistent GI inflammation and the recurrence of IBD. Finally, we discuss potential therapeutic interventions involving senotherapeutic agents, providing insights into potential avenues for managing IBD by targeting ENS-related mechanisms. This approach might represent a potential alternative to managing IBD and advance treatment of this multifaceted disease.

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Curcumin and Gut Microbiota: A Narrative Overview with Focus on Glycemic Control

Servida,

Piontini,

Gori

et al. 2024

IJMS

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Turmeric is a spice widely used in China, Southeast Asia, and in traditional Ayurvedic medicine. Its safety profile and efficacy as an antioxidant, anti-inflammatory, antimicrobial, antitumor, antidiabetic, and anti-obesity agent have led to extensive research into its potential role in preventing and treating metabolic diseases. The active compound in turmeric is curcumin, which exhibits low systemic bioavailability after oral administration. However, it is detectable in the gut, where it bidirectionally interacts with the gut microbiota (GM), which plays a crucial role in maintaining host health. The favorable effects of curcumin, particularly its hypoglycemic properties, are linked to alteration in intestinal dysbiosis observed in type 2 diabetes mellitus and metabolic syndrome patients. Restoration of the eubiotic GM may contribute to glycemic homeostasis. Preclinical and clinical studies have demonstrated the involvement of the GM in the regulation of glucose and lipid metabolism. Although the underlying mechanism remains incompletely understood, intestinal dysbiosis is associated with insulin resistance, hyperglycemia, and low-grade inflammation. In the present overview, we summarize the biological properties of curcumin, focusing on its link with GM and, therefore, on its potential role in metabolic diseases.

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The Effect of Curcumin on the Gut-Brain Axis: Therapeutic Implications

Cited by 3 publications

References 48 publications

Enhancing the Bioavailability and Bioactivity of Curcumin for Disease Prevention and Treatment

Enhancing the Bioavailability and Bioactivity of Curcumin for Disease Prevention and Treatment

Enteric Nervous System Alterations in Inflammatory Bowel Disease: Perspectives and Implications

Curcumin and Gut Microbiota: A Narrative Overview with Focus on Glycemic Control

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