The effect of curcumin (Curcuma longa L.) on circulating levels of adiponectin in patients with metabolic syndrome

Salahshooh, Malihe Moammeri; Parizadeh, Seyed Mahammad Raza; Pasdar, Alireza; Karimian, Maryam Saberi; Safarian, Hamide; Javandoost, Ali; Ferns, Gordon A.; Ghayour‐Mobarhan, Majid; Sahebkar, Amirhosein

doi:10.1007/s00580-016-2339-5

Cited by 18 publications

(34 citation statements)

References 44 publications

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“…It stimulates fatty acid oxidation predominantly in skeletal muscle to activate glucose uptake [ 137 ]. Increased adiponectin levels were observed with curcumin supplementation (1 g/day) for 6 weeks in subjects with metabolic syndrome compared with a curcumin-phospholipid complex group or a placebo group, whereas no differences in BMI, body weight, waist circumference, fasting blood glucose, fat (%) were observed compared with a curcumin-phospholipid complex group or a placebo group [ 138 ].…”

Section: Effects Of Curcumin On Cardiometabolic Healthmentioning

confidence: 99%

“…The effect of curcumin on glucose control is inconclusive, as five RCTs [ 57 , 134 , 135 , 136 , 139 ] showed positive effects and ten RCTs [ 80 , 81 , 108 , 138 , 140 , 142 , 143 , 144 , 145 , 146 ] showed no effect.…”

Section: Effects Of Curcumin On Cardiometabolic Healthmentioning

confidence: 99%

“…In a systematic review [ 185 ] of 8 RCTs [ 46 , 81 , 100 , 134 , 135 , 139 , 143 , 186 ], 3 studies [ 46 , 134 , 139 ] showed a favourable effect on weight control while 5 studies [ 81 , 100 , 135 , 143 , 186 ] showed no effects [ 185 ]. Moreover, RCTs [ 136 , 138 , 142 ] included in this review showed no effect, and RCTs [ 45 , 57 ] showed a positive effect on weight control. Given the findings from limited numbers of RCTs [ 45 , 46 , 57 , 81 , 100 , 134 , 135 , 136 , 138 , 139 , 142 , 143 , 186 ], curcumin at usual doses is unlikely to contribute to weight control.…”

Section: Effects Of Curcumin On Cardiometabolic Healthmentioning

confidence: 99%

“…Moreover, RCTs [ 136 , 138 , 142 ] included in this review showed no effect, and RCTs [ 45 , 57 ] showed a positive effect on weight control. Given the findings from limited numbers of RCTs [ 45 , 46 , 57 , 81 , 100 , 134 , 135 , 136 , 138 , 139 , 142 , 143 , 186 ], curcumin at usual doses is unlikely to contribute to weight control.…”

Section: Effects Of Curcumin On Cardiometabolic Healthmentioning

confidence: 99%

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Curcumin, Cardiometabolic Health and Dementia

Kim

Clifton

2018

IJERPH

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Current research indicates curcumin [diferuloylmethane; a polyphenolic compound isolated from the rhizomes of the dietary spice turmeric (Curcuma longa)] exerts a beneficial effect on health which may be partly attributable to its anti-oxidative and anti-inflammatory properties. The aim of this review is to examine potential mechanisms of the actions of curcumin in both animal and human studies. Curcumin modulates relevant molecular target pathways to improve glucose and lipid metabolism, suppress inflammation, stimulate antioxidant enzymes, facilitate insulin signalling and reduce gut permeability. Curcumin also inhibits Aβ and tau accumulation in animal models and enhances mitochondria and synaptic function. In conclusion, in high-dose animal studies and in vitro, curcumin exerts a potential beneficial effect on cardiometabolic disease. However, human studies are relatively unconvincing. More intervention studies should be conducted with the new curcumin formulation with improved oral bioavailability.

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Section: Effects Of Curcumin On Cardiometabolic Healthmentioning

confidence: 99%

Section: Effects Of Curcumin On Cardiometabolic Healthmentioning

confidence: 99%

Section: Effects Of Curcumin On Cardiometabolic Healthmentioning

confidence: 99%

Section: Effects Of Curcumin On Cardiometabolic Healthmentioning

confidence: 99%

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Curcumin, Cardiometabolic Health and Dementia

Kim

Clifton

2018

IJERPH

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“…Several therapeutic and pharmacologic properties of C. longa have recently been reported; antioxidant activity [13][14][15], cardiovascular and anti-diabetic effects [16][17][18] inflammatory and edematic disorders [19][20][21], anti-cancer [22,23], [26,27], anti-microbial [24][25], hepatoprotection [26,27] protection against Alzheimers [28][29][30], photo protector [12,31]. Although majority of spices and medicinal herbs are commonly presumed to be safe, adverse effects occasionally arise after the consumption of herbal products.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical evaluation, Embryotoxicity and Teratogenic effects of Curcuma longa extract in Zebrafish (Danio rerio)

Alafiatayo

Song

Ahmad

et al. 2019

Preprint

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Curcuma longa L. is a rhizome plant often used as traditional medicinal preparations in Southeast Asia. The dried powder is commonly known as cure-all herbal medicine with a wider spectrum of pharmaceutical activities. In spite of the widely reported therapeutic applications of C. longa, research on its safety and teratogenic effects on zebrafish embryos and larvae is still limited. Hence, this research was aimed to assess the toxicity of C. longa extract on zebrafish. Using a reflux flask, methanol extract of C. longa was extracted and the identification and quantification of total flavonoids were carried out with HPLC. Twelve fertilized embryos were selected to test the embryotoxicity and teratogenicity at different concentration points. The embryos were exposed to the extract in the E3M medium while the control was only exposed to E3M and different developmental endpoints were recorded with the therapeutic index calculated using the ratio of LC50/EC50. C. longa extract was detected to be highly rich in flavonoids with catechin, epicatechin and naringenin as the 3 most abundant with concentrations of 3,531.34, 688.70 and 523.83μg/mL respectively. The toxicity effects were discovered to be dose-dependent at dosage above 62.50μg/mL, while at 125.0μg/mL, mortality of embryos was observed and physical body deformities of larvae was recorded among the hatched embryos at higher concentrations. Teratogenic effect of the extract was severe at higher concentrations producing physical body deformities such as kink tail, bend trunk, enlarged yolk sac edema. Finally, the Therapeutic Index (TI) values calculated were approximately same for different concentration points tested. Overall, the result revealed that plants having therapeutic potential could also pose threats when consumed at higher doses especially on the embryos. Therefore, detailed toxicity analysis should be carried out on medicinal plants to ascertain their safety on the embryos and its development. Abbreviations:DMSO, dimethyl sulfoxide; HPLC, high performance liquid chromatography; OECD, organisation for economic cooperation and development; FET, fish embryo acute toxicity test; hpf, hour of post fertilization.

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Hormetic effects of curcumin: What is the evidence?

Moghaddam

Nosrati‐Oskouie

Butler³

et al. 2018

Journal Cellular Physiology

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Curcumin (diferuloylmethane), a component of the yellow powder prepared from the roots of Curcuma longa or Zingiberaceae (known as turmeric) is not only widely used to color and flavor food but also used as a pharmaceutical agent. Curcumin demonstrates anti‐inflammatory, anticarcinogenic, antiaging, and antioxidant activity, as well as efficacy in wound healing. Notably, curcumin is a hormetic agent (hormetin), as it is stimulatory at low doses and inhibitory at high doses. Hormesis by curcumin could be also a particular function at low doses (i.e., antioxidant behavior) and another function at high dose (i.e., induction of autophagy and cell death). Recent findings suggest that curcumin exhibits biphasic dose–responses on cells, with low doses having stronger effects than high doses; examples being activation of the mitogen‐activated protein kinase signaling pathway or antioxidant activity. This indicates that many effects induced by curcumin are dependent on dose and some effects might be greater at lower doses, indicative of a hormetic response. Despite the consistent occurrence of hormetic responses of curcumin in a wide range of biomedical models, epidemiological and clinical trials are needed to assess the nature of curcumin’s dose–response in humans. Fortunately, more than one hundred clinical trials with curcumin and curcumin derivatives are ongoing. In this review, we provide the first comprehensive analysis supportive of the hormetic behavior of curcumin and curcumin derivatives.

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The effect of curcumin (Curcuma longa L.) on circulating levels of adiponectin in patients with metabolic syndrome

Cited by 18 publications

References 44 publications

Curcumin, Cardiometabolic Health and Dementia

Curcumin, Cardiometabolic Health and Dementia

Phytochemical evaluation, Embryotoxicity and Teratogenic effects of Curcuma longa extract in Zebrafish (Danio rerio)

Hormetic effects of curcumin: What is the evidence?

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