The Effect of Curcumin (Active Substance of Turmeric)on the Acetic Acid-Induced Visceral Nociception in Rats

Tajik, Hossein; Tamaddonfard, Esmaeal; Hamzeh-Gooshchi, Nasrin

doi:10.3923/pjbs.2008.312.314

Cited by 59 publications

(50 citation statements)

References 13 publications

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“…They were kept under a 12/12 hour light/dark cycle 27 with the room temperature of 28 0 C ±5 0 C (which was corresponded to the thermo-neutral zone of rats 28 ) at the Pain laboratory of the Department of Physiology, BSMMU. The animals were there for consecutive active due to any ongoing damage of the tissue or organism 3 .…”

Section: Experimental Animalsmentioning

confidence: 99%

Antinociceptive and Anti-inflammatory Effects of Combined Administration of a-tocopherol and Morphine in Long Evans Rats

Habib

Begum

Ali

et al. 2017

Anwer Khan Mod Med Coll J

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Background: Morphine is an opioid analgesic which is used to treat moderate to severe pain but has a number of side effects. This study is aimed to explore that combination of morphine and a-tocopherol (aT) are better analgesic as well as anti-inflammatory effect than that of morphine alone.Objective: To assess the effects of combination of morphine with a-tocopherol on pain and inflammation.Methods: This prospective experimental study was conducted in the Department of Physiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbag, Dhaka from January 2013 to December 2013. For this purpose, 15 male Long Evans rats were studied. On the basis of vitamin and drug administrations, the rats were divided into three (3) groups (5 rats in each). Control group received normal saline, one experimental group received morphine sulphate (MS) at a dose of 3 mg/kg body weight and another experimental group received combination of MS with aT at a dose of 3 mg/kg body weight and 500 mg/kg body weight, respectively. All the groups received single dose and equal volume (1 ml) through intraperitoneal route 1 hour before the test. Just one hour after administrations, they were subjected to formalin test followed by formalin induced paw edema test. The data were statistically analyzed by ANOVA followed by Bonferroni Post Hoc test.Results: Combined administration of MS and aT lowered the variables for nociceptive pain, central analgesic activity, inflammatory pain as well as inflammation than individual administration of MS.Conclusion: From this study it may be concluded that combined administration of morphine sulphate and atocopherol were more effective in lowering pain and inflammation than individual administration of morphine.Anwer Khan Modern Medical College Journal Vol. 8, No. 1: Jan 2017, P 24-29

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Section: Experimental Animalsmentioning

confidence: 99%

Antinociceptive and Anti-inflammatory Effects of Combined Administration of a-tocopherol and Morphine in Long Evans Rats

Habib

Begum

Ali

et al. 2017

Anwer Khan Mod Med Coll J

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show abstract

“…All the rats were kept in the Pain laboratory of the Department of Physiology, BSMMU, where they were housed in specially built plastic cages with 6 rats per cage under a 12/12 hour light/dark cycle [29][30][31] . The ambient room temperature was maintained at around 27 to 28°C, corresponding to the thermo-neutral zone for rodents 32,33 .…”

Section: Procurement and Maintenance Of Animalsmentioning

confidence: 99%

?-Tocopherol and Ketorolac on Pain in Long Evans Rats

Rouf

Begum

Ali

et al. 2017

J Bangladesh Soc Physiol

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Background: Alpha-tocopherol (αT) is a form of vitamin E that is widely known to be one of the reactive oxygen species scavengers (ROS) and it has been shown to have analgesic effects in different animal and human studies. But comparison of these effects with similar effects of ketorolac tromethamine (KT) and their combination have not been established. Objective: To assess the effects of αT on pain and also compare them with those of the combinations of αT with KT in rat models.Methods: This experimental study was conducted in the Department of Physiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, from March 2015 to February 2016. For this, 20 (twenty) Long Evans rats (215±35 gm) of both sexes were divided into control (A, with 5mL/kg normal saline) and experimental (B1, with 500mg/kg αT; B2, with 10mg/kg KT; B3, with αT+KT) groups with 5 (five) rats in each group. All the drugs and vitamins were administered intraperitoneally in a single dose, just one hour before formalin test.To evaluate the effect of treatments on nociceptive pain, early phase (1 st -5 th minutes); on central analgesic system, interphase (6 th -15 th minutes); and on inflammatory pain, late phase (16 th -60 th minutes) of the formalin test, were observed. In all phases, total frequency of jerking and total duration of flexing and licking of the right hind paw were counted after administration of subcutaneous formalin (50 µL, 2.5%) injection. Statistical analysis was done by ANOVA, followed by Bonferroni post hoc test. In the interpretation of results, p≤0.05 was considered as significant. Results: αT lowered flexing and licking duration significantly (p≤0.001) in early and late phases. KT lowered flexing and licking duration significantly (P<0.001) in late phase of formalin test. On the other hand, combination of αT and KT significantly (p≤0.001) lowered both the study variables in early and late phase of formalin test. Conclusion: From this study it may be concluded that, αT possesses analgesic effects and combination of αT with KT is more effective than those of their individual administration.

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“…Curcumin isolated from Curcuma longa has shown to be nontoxic and non-mutagenic and exhibits a wide spectrum of biological activities which include neuroprotective, antiinflammatory, antidepressant, and antioxidant activity (Fan et al, 2013;Gupta et al, 2013). Curcumin has also been reported to exert antinociceptive effects in different animal models of pain (Mittal et al, 2009;Tajik et al, 2008), which also includes diabetic neuropathic pain (Sharma et al, 2006). With the above background, the present study was undertaken to investigate the effect of curcuminin vincristine-induced neuropathic pain in a mice model.…”

Section: Introductionmentioning

confidence: 99%

Effect of curcumin in mice model of vincristine-induced neuropathy

Babu¹,

Prasanth²,

Bhaskar³

2014

Pharmaceutical Biology

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Context: Curcumin exhibits a wide spectrum of biological activities which include neuroprotective, antinociceptive, anti-inflammatory, and antioxidant activity. Objective: The present study evaluates the effect of curcumin in vincristine-induced neuropathy in a mice model. Materials and methods: Vincristine sulfate (0.1 mg/kg, i.p. for 10 consecutive days) was administered to mice to induce neuropathy. Pain behavior was assessed at different days, i.e., 0, 7, 10, and 14 d. Sciatic nerve total calcium, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), nitric oxide (NO), and lipid peroxidation (LPO) were also estimated after the 14th day of study. Pregabalin (10 mg/kg, p.o.) and curcumin (15, 30, and 60 mg/kg, p.o.) were administered for 14 consecutive days. Results: Curcumin at 60 mg/kg significantly attenuated the vincristine-induced neuropathic pain manifestations in terms of thermal hyperalgesia (p50.001) and allodynia (p50.001); mechanical hyperalgesia (p50.001); functional loss (p50.001); and in the delayed phase of formalin test (p50.001). Curcumin at 30 and 60 mg/kg exhibited significant changes (p50.001) in antioxidant levels and in total calcium levels in vincristine-injected mice. Conclusion: Curcumin at 30 and 60 mg/kg dose levels significantly attenuated vincristineinduced neuropathy which may be due to its multiple actions including antinociceptive, calcium inhibitory, and antioxidant effect.

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The Effect of Curcumin (Active Substance of Turmeric)on the Acetic Acid-Induced Visceral Nociception in Rats

Cited by 59 publications

References 13 publications

Antinociceptive and Anti-inflammatory Effects of Combined Administration of a-tocopherol and Morphine in Long Evans Rats

Antinociceptive and Anti-inflammatory Effects of Combined Administration of a-tocopherol and Morphine in Long Evans Rats

?-Tocopherol and Ketorolac on Pain in Long Evans Rats

Effect of curcumin in mice model of vincristine-induced neuropathy

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