The effect of Crocus sativus (saffron) on the severity of premenstrual syndrome

Premenstrual syndrome: new insights into etiology and review of treatment methods

“…In the study by Beiranvand et al., saffron was administered once a day for two menstrual cycles at a dose of 30 mg, revealing a significant decrease in PMS severity in the saffron group compared to the placebo group ( 213 ). This finding aligns with an earlier study by Agha-Hosseini et al., where saffron, at a total dose of 30 mg divided into two doses of 15 mg each, demonstrated a notable reduction in PMS symptoms for up to 76% of women after two monthly cycles of administration ( 214 ).…”

Saffron

“…Mechanisms for saffron's influence on dyslipidemia and atherosclerosis may include interfering with gastrointestinal tract lipases after meals, increasing serum adiponectin levels, enhancing antioxidant and anti-inflammatory mechanisms, lowering blood pressure and platelet aggregation, and modulating signaling pathways such as those involving peroxisome proliferator-activated receptor γ and heat shock proteins. 12,[90][91][92][93] Additional Miscellaneous Actions There is limited and inconclusive evidence that saffron may help treat sexual dysfunction, [94][95][96] certain ocular diseases, 97,98 premenstrual syndrome, [99][100][101][102] insomnia, [103][104][105] and multiple sclerosis. [106][107][108]…”

Analysis of the Effect of 60Co-γ Irradiation Sterilization Technology on the Chemical Composition of Saffron Using UPLC and UPLC/Q-TOF-MS

“…Saffron (Iridaceae) reportedly has certain positive health effects, such as activating blood flow and removing blood stasis, cooling the blood detoxification, removing depression, and anchoring the mind [14]. It is widely used to promote good blood circulation, to relieve blood stasis [15] and to treat cardiovascular disease [16].…”