The Effect of Commonly Used Antiseptics on Wound Healing

Gruber, Ronald P.; Vistnes, Lars M.; Pardoe, Russel

doi:10.1097/00006534-197504000-00013

Cited by 34 publications

(18 citation statements)

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“…Results in man correlate well with porcine studies. In studies of partial‐thickness wounds in man performed by Gruber et al, wounds were treated with 10% povidone‐iodine every 6 hours until complete healing 50 . Povidone‐iodine–treated wounds healed significantly more rapidly than control wounds exposed to air (9.3 days vs. 12.4 days) and did not heal at a rate significantly different from saline‐treated wounds.…”

Section: Topical Antimicrobials/antibioticsmentioning

confidence: 99%

The Pig as a Model for Human Wound Healing

Sullivan

Eaglstein

Davis

et al. 2001

Wound Repair Regeneration

890

727

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The medical literature describes numerous in vitro and in vivo wound-healing models. The selection of an animal model depends on a number of factors including availability, cost, ease of handling, investigator familiarity, and anatomical/functional similarity to humans. Small mammals are frequently used for wound healing studies, however, these mammals differ from humans in a number of anatomical and physiological ways. Anatomically and physiologically, pig skin is more similar to human skin. The many similarities between man and pig would lead one to believe that the pig should make an excellent animal model for human wound healing. The purpose of this paper is to review the existing literature for evidence of this supposition and determine how well the various models correlate to human wound healing. Studies of wound dressings, topical antimicrobials, and growth factors are examined. Over 180 articles were utilized for this comparative review. Our conclusion is that the porcine model is an excellent tool for the evaluation of therapeutic agents destined for use in human wounds.

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Section: Topical Antimicrobials/antibioticsmentioning

confidence: 99%

The Pig as a Model for Human Wound Healing

Sullivan

Eaglstein

Davis

et al. 2001

Wound Repair Regeneration

890

727

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“…Be aware that some skin cleaners or antiseptics may destroy granulation tissue [10]. Avoid hydrogen peroxide as it is toxic to tissues even at low concentrations [40,41]and should not be used as a preferred topical antiseptic. Its use should be completely avoided in cavity wounds due to the risk of surgical emphysema and gas embolus [28,[41][42][43].…”

Section: Topical Antisepticsmentioning

confidence: 99%

Pressure Injury in the ICU: Major Reconstructive Surgery Required

Jordan¹

2017

Vignettes in Patient Safety - Volume 1

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Pressure injury (PI) has replaced the former nomenclature pressure ulcer, a change initiated by the National Pressure Ulcer Advisory Panel (NPUAP) however, substitutes such as pressure ulcers, decubitus ulcers, and bedsores will continue to be used by many. Increased knowledge and awareness of PIs has lead to a decline in their overall prevalence. A review of the most common risk factors, including two risk factor assessment tools, the Braden scale and the Cubbin & Jackson are presented. Diagnosing PIs must be a methodical, meticulous process in order to accurately document and monitor their progression and improvement. In 2016 the NPUAP revised the definitions as well as the stages of PIs incorporating the etiology and anatomical features present or absent in each stage of injury. Treatment strategies such as managing co-morbidities, nutrition optimization, and pain management are important aspects to consider in treating PIs in addition to thorough wound care cleansing and debridement. Highlighted are the various effective debridement options such as surgical sharp, mechanical, autolytic, enzymatic and larval debridement. Wound dressing alternatives, their advantages, disadvantages, indications and contraindications are all are mentioned. Concluding the chapter are pressure injury rates of healing, prognosis and surgical indications.

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“…87 The ''bubbling'' action may enhance mechanical cleansing of necrotic debris from wounds in inaccessible areas. 88 However, studies have shown that hydrogen peroxide has relatively weak antimicrobial activity. 26,87 Interestingly, methicillin-resistant S. aureus has been shown to be susceptible to 3% hydrogen peroxide in vitro.…”

Section: Hydrogen Peroxidementioning

confidence: 99%

“…[89][90][91] Recently, hydrogen peroxide has decreased in popularity due to its deleterious effects on wound healing. [92][93][94] Adverse effects include inhibition of keratocyte migration and proliferation, 95 formation of bullae under new epithelium, 88 decreased wound tensile strength, 17 and impaired fibroblast activity. 96 Hydrogen peroxide also can prematurely degrade fast-absorbing gut suture, which may subsequently lead to widened or hypertrophic scarring.…”

Section: Hydrogen Peroxidementioning

confidence: 99%

Postoperative Care of the Facial Laceration

Medel

Panchal

Ellis

2010

Craniomaxillofacial Trauma & Reconstruction

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The purpose of this investigation is to examine factors involved in the postoperative care of traumatic lacerations. An evidence-based comprehensive literature review was conducted. There are a limited number of scientifically proven studies that guide surgeons and emergency room physicians on postoperative care. Randomized controlled trials must be conducted to further standardize the postoperative protocol for simple facial lacerations.KEYWORDS: Laceration, wound closure, postoperative careThe management of facial lacerations is common for surgeons who take trauma call at their local hospitals and for emergency room physicians. In fact, we have more calls to the emergency rooms for treatment of soft tissue injuries at our hospitals than we do for bony injuries. Because of the visibility of the face, it should not be surprising that much attention has been given to the technique(s) for the closure of traumatic facial lacerations. Studies are plentiful that evaluate a host of factors, such as methods of cleansing and debridement, types of sutures, layered versus nonlayered closure, use of adhesives rather than sutures, and so on. There is a paucity of information, however, about what to do after the laceration has been closed. Most texts on the management of facial injuries mention very little regarding this topic.Most of the aftercare recommended for facial lacerations seems to be based upon the varied opinions of the individual surgeon rather than on scientific factors. In fact, there seems to be no consensus, and often what is recommended by one surgeon is castigated by another.The purpose of this article is to examine the factors involved in postoperative care of traumatic lacerations. We have tried to identify the most scientific information available to make treatment recommendations, but it should be realized that good evidence for much of what is currently being done is not based on science, and just as importantly, there is not much science on this topic to guide the clinician. Although we are discussing the treatment of traumatic facial lacerations, much of the studies that are available have been performed on lacerations elsewhere in the body. However, there is no reason to believe that they aren't applicable the facial region. The information presented here should also apply to incisions made on the face for any reason. SURGICAL TAPESurgical tape to reinforce sutured lacerations at the time of closure and after suture removal is often used as adjunctive wound care. Surgical tape theoretically minimizes skin tension. In a cadaveric study, the reinforcement of surgical tape with mastisol over a sutured skin incision exhibited a slightly higher strength against separating forces when compared with sutures alone,

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The Effect of Commonly Used Antiseptics on Wound Healing

Cited by 34 publications

References 0 publications

The Pig as a Model for Human Wound Healing

The Pig as a Model for Human Wound Healing

Pressure Injury in the ICU: Major Reconstructive Surgery Required

Postoperative Care of the Facial Laceration

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