The Effect of Combined Treatment with Oral Clindamycin and Oral Rifampicin in Patients with Hidradenitis Suppurativa

Zee, Hessel H. van der; Boer, Jurr; Prens, Errol P.; Jemec, Gregor B. E.

doi:10.1159/000228337

Cited by 184 publications

(124 citation statements)

References 52 publications

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“…The combination of clindamycin (300 mg bid) and rifampicin (600 mg daily given either as 1 or 2 doses) for 10 weeks has been proved beneficial in more widely spread Hurley stage I or mild stage II disease [55][56][57] . Significantly lower results are reported with acitretin, cyclosporin A, oral dapsone, oral isotretinoin [58][59][60] . Moreover, the European Medicine Agency has recently accepted HS as an indication of a monoclonal anti-TNF-α antibody such as adalimumab [61][62][63] .…”

Section: Hidradenitis Suppurativamentioning

confidence: 85%

Photodynamic Therapy and Skin Appendage Disorders: A Review

Megna

Fabbrocini

Marasca

et al. 2016

Skin Appendage Disord

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Photodynamic therapy (PDT) is a noninvasive treatment that utilizes light treatment along with application of a photosensitizing agent. In dermatology, PDT is commonly used and approved for the treatment of oncological conditions such as actinic keratosis, Bowen disease and superficial basal cell carcinoma. In the last 2 decades however, PDT has also been used for the treatment of several nonneoplastic dermatological diseases. The present review summarizes published data on PDT application in skin appendage disorders. Our literature review shows that: (a) PDT may be a suitable treatment for acne, folliculitis decalvans, hidradenitis suppurativa, nail diseases, and sebaceous hyperplasia; (b) there is a lack of agreement on PDT features (type, concentrations and incubation period of used substances, number and frequency of PDT sessions, optimal parameters of light sources, and patient characteristics [e.g., failure to previous treatments, disease severity, body surface area involved, etc.] which should guide PDT use in these diseases); (c) further research is needed to establish international guidelines helping dermatologists to choose PDT for the right patient at the right time.

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Section: Hidradenitis Suppurativamentioning

confidence: 85%

Photodynamic Therapy and Skin Appendage Disorders: A Review

Megna

Fabbrocini

Marasca

et al. 2016

Skin Appendage Disord

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“…However, since in these studies different doses and different outcome variables were used to assess efficacy (Table 3), it is difficult to compare or group these studies. In three retrospective studies, 164 patients were treated of whom 88 patients completed a 10-week course of clindamycin 300 mg twice daily, and rifampicin 600 mg once daily or 300 mg twice daily [46][47][48]. Twentyone patients could not complete the treatment period because of side effects, mostly diarrhea and nausea.…”

Section: Clindamycin and Rifampicin Combination Therapymentioning

confidence: 99%

An Update on Medical Treatment Options for Hidradenitis Suppurativa

Deckers

Prens

2015

Drugs

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Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease characterized by recurrent inflammatory nodules mostly located in the armpits and groin. Over the years multiple treatments for HS have been proposed; however, to date a cure is still lacking. In this update we provide an overview of most drug treatments reported on for HS, where possible with their mode of action and side effects. In mild cases, clindamycin lotion or resorcinol cream have proven effective. Tetracyclines are a first-line systemic option in more widespread or severe cases, followed by the combination of clindamycin and rifampicin. However, the recurrence rate is high after discontinuation of clindamycin plus rifampicin combination therapy. Long-term treatment with retinoids, especially acitretin is feasible, although teratogenicity has to be taken into account in females of reproductive age. Multiple antiinflammatory drugs have been suggested for HS, such as dapsone, fumarates or cyclosporine. However, their effectiveness in HS is based on small case series with varying results. If most common treatments have failed, biologics (e.g., infliximab or adalimumab) are the next step. Although not addressed in this review, surgical interventions are often needed to achieve remission. Key PointsHidradenitis suppurativa (HS) is a chronic inflammatory skin disease without a cure.Antibiotics (topical or oral) are often the first treatment option for HS.In cases of more extensive or therapy-resistant HS, biologicals (e.g., infliximab or adalimumab) are a good therapeutic option.

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“…formájában javasoltak. Három retrospektív (n=116) és egy prospektív (n=23) klinikai vizsgálat során clindamycin és rifampicin kombinációjával a betegek 80-85%-ánál észleltek klinikai választ (33)(34)(35)(36). A kezelések során jelentkező leggyakoribb mellékhatás (13-22%) gasztrointesztinális jellegű volt.…”

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Hidradenitis suppurativa: why isn’t it a form of acne?

Törőcsik¹,

Kinyó²,

Kovács³

et al. 2016

BVSZ

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ÖSSZEFOGLALÁSKey words: acne inversa, acne vulgaris, hidradenitis suppurativa 1. Patogenezis Acne inversa: miért nem acne és nem is hidradenitis?A betegség korábbi nevével, az acne inversával joggal leszámolva, hisz nem ott, nem akkor és nem úgy jelenik meg, mint a serdülőkori acne, sokak számára a jellegzetes lokalizációból adódóan egyértelmű patogenetikai tényező-ként az apokrin mirigyek foglalták el a központi helyet. A tünetek típusos intertriginózus megjelenése kétséget kizá-róan rámutat az adott terület jellegzetességeinek szerepére, melyek nagyban hozzájárulhatnak a betegség kialakulásá-hoz. Számos elmélet született már, részleges magyarázatot adva a hidradenitis suppurativa (HS) patogenezisére, mint például a fokozott mechanikai irritáció szerepe, vagy a terület eltérő higiénés jellemzői, immunológiai sajátossá-gai, melyben a fokozott nedvesség kaphat központi szerepet. Ugyanakkor a szövettani vizsgálatok alapján az apokrin mirigyek csak az előrehaladott formákban voltak érint-ve és akkor is sokkal inkább a végpontjai mint sem aktív szereplői voltak a patológiai folyamatoknak (1).Az utóbbi évek kutatásai a faggyúmirigyek szerepére is ráirányították a figyelmet, melyhez nagyban hozzájárultak azok a szövettani leletek, melyek a faggyúmirigyek elpusztulását már a HS kezdeti stádiumában leírták (2). A szövet-tani minták elemzésének másik szembetűnő lelete az acné-ből jól ismert follicularis hiperkeratinizáció/okklúzió volt, mely a folliculusok kitágulásához majd roncsolódásához vezet, így a baktériumokban gazdag törmelék a dermist infiltrálva annak gyulladását eredményezi felvetve, hogy a baktériumok és a különböző gyulladásos útvonalak éppúgy fontosak lehetnek ebben a betegségben is (1. ábra). A gyulladásban szerepet játszó sejteken az acnéban ismerthez hasonlóan, szintén fokozottan vannak jelen a Toll-like 129

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The Effect of Combined Treatment with Oral Clindamycin and Oral Rifampicin in Patients with Hidradenitis Suppurativa

Cited by 184 publications

References 52 publications

Photodynamic Therapy and Skin Appendage Disorders: A Review

Photodynamic Therapy and Skin Appendage Disorders: A Review

An Update on Medical Treatment Options for Hidradenitis Suppurativa

Hidradenitis suppurativa: why isn’t it a form of acne?

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