The Effect of Coenzyme Q10 on the Regeneration of Crushed Facial Nerve

Yıldırım, Güven; Kumral, Tolgar Lütfı; Berkıten, Güler; Saltürk, Zıya; Sünnetçi, Gürcan; Öztürkçü, Yusuf; Uyar, Yavuz; Kamali, Gulcin

doi:10.1097/scs.0000000000001201

Cited by 11 publications

(9 citation statements)

References 24 publications

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“…Another antioxidant that has been studied for use in supporting the regeneration of crushed facial nerve is coenzyme Q. 24 Coenzyme Q was also found to be effective in promoting the regeneration of the nerve in an experimental facial nerve crush rat model.…”

Section: Discussionmentioning

confidence: 99%

“…There are a number of nerve integrity monitoring devices available to identify and preclude persistent nerve damage. 28 , 29 In this study, we used the Nerve Integrity Monitor facial electromyography technique described by Delgado et al 29 and used in several previous studies 15 , 24 to record the contraction of facial muscles. In the present study, although not reaching statistical significance, there was improvement in facial nerve function in the ozone group when assessed using threshold levels.…”

Section: Discussionmentioning

confidence: 99%

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Effects of ozone therapy on facial nerve regeneration

Özbay

İtal²,

Kucur

et al. 2017

Brazilian Journal of Otorhinolaryngology

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effects of ozone therapy on facial nerve regeneration

Özbay

İtal²,

Kucur

et al. 2017

Brazilian Journal of Otorhinolaryngology

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“…This is in accordance of Ozbay et al [18] who reported that there was improvement in facial nerve function after ozone therapy. This regeneration was evaluated by assessment of the degree of macrovacuolization, vascular congestion, and myelin sheath thickness [44] . Valko et al [45] suggested that Ozone may promote a moderate oxidative stress that in turn increases endogenous antioxidant systems leading to a decrease in free radicals.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Long Term Administration of Aspartame on the Sciatic nerve of adult male albino rats and the Possible Therapeutic Role of Ozone (Histological and Biochemical Study)

Hassen¹,

mahmod

Ibrahem

et al. 2019

Egyptian Journal of Histology

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Introduction: Aspartame is a widely used artificial non-nutritive sweetener, which replaced sucrose in foods for enhancing flavor while reducing calories. It was confirmed that aspartame was a multipotential carcinogenic agent increases the risk of lymphoma and neurological tumors. Aim of the work: This work is aimed to evaluate the effect of aspartame on the structure of the sciatic nerve and the possible role of ozone therapy. Material and methods: The present study was carried out on 30 adult male wister albino rats divided into three groups: control (I), aspartame(II) and ozone and aspartame treated (III) groups. Group (II) received aspartame (250 mg/kg/d) dissolved in distilled water and administered by gastric tube for 3 months. Group (III) received aspartame as in Group II, then received an ozone dose of 1.1 mg/kg/d intraperitoneal (IP) for 30 days. Rats were anesthetized and sciatic nerves were processed for light, electron microscope, morphometric and Real time-PCR analysis. Results: The sciatic nerve of aspartame group showed loss of regular architecture, separation of myelin lamellae with splitting of myeline sheath. Schwann cells appeared with vacuolated cytoplasm and collagen fibrils could be seen in the endoneurium. Immunohistochemically, there was decrease in expression of myeline basic protein (MBP) in myeline sheath and decrease in axon/fiber ratio (g ratio) statistically. Apparent structural and histomorphological improvement were noticed in ozone group. Conclusion: Aspartame induced histopathological changes in sciatic nerve. Our data suggests that ozone therapy has an important role in sciatic nerve regeneration by increasing the expression of neurotrophic and angiogenic factors establishing more favorable environment for nerve regeneration.

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“…The main cause in the therapy of ELP is complete withdrawal of patients’ painful symptoms, epithelialization of the eroded mucosal lesions and oral carcinoma prevention. There are various therapeutic procedures described and implemented in practice till this day including topical medications, steroid ointments, ultraviolet rays (PUVA) [ 15 ] and laser [ 16 ]. However, the era of new medications increasingly conquers the world, and is also applied in the treatment of the oral mucosal lesions, including ELP.…”

Section: Discussionmentioning

confidence: 99%

The Effects of NBF Gingival Gel Application in the Treatment of the Erosive Lichen Planus: Case Report

Поповска

Fidovski²,

Mindova

et al. 2016

Open Access Maced J Med Sci

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The therapy of erosive lichen planus (ELP) has been particular problem in the treatment of oral lesions. This case of ELP in male patient 29 years old was treated with topic application of the NBF gingival gel, three times a day after meal, previously rinsed with Clorhexidine gluconate 0.12%. After 5 days of treatment, initial improvements were recorded, and after two weeks of application of the NBF gingival gel we observed significant improvement. Clinical monitoring after the fifth day showed mild epithelialization of the eroded mucosa, yet still present erythematous base of the lesion. After the second week the erythema area was significantly reduced and the eroded surfaces of the mucosa were minimal, measured less than 0.5 mm. After the third week there were no erosions to detect on the oral mucosa, yet still present vague redness, which completely pulled after the fourth week. Treatment ended after the fifth week when the topical application of the NBF gingival gel was terminated, and therapy was done, and clinically achieved effects remained stable even after the third month of the treatment. Topic application of the NBF gingival gel with ELP patients showed positive clinical effects in relatively short time period.

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The Effect of Coenzyme Q10 on the Regeneration of Crushed Facial Nerve

Abstract: Although many treatment methods have been tried to accelerate facial nerve regeneration after trauma, a definitive method has not been found yet. Co Q for the treatment of acute facial paralysis is promising on both physiologic assessments and pathologic evaluation.

Cited by 11 publications

References 24 publications

Effects of ozone therapy on facial nerve regeneration

Effects of ozone therapy on facial nerve regeneration

The Effect of Long Term Administration of Aspartame on the Sciatic nerve of adult male albino rats and the Possible Therapeutic Role of Ozone (Histological and Biochemical Study)

The Effects of NBF Gingival Gel Application in the Treatment of the Erosive Lichen Planus: Case Report

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