Effects of ozone therapy on facial nerve regeneration

Özbay, İsa; İtal, İlker; Kucur, Cüneyt; Akçılar, Raziye; Deger, Aysenur; Aktaş, Savaş; Oğhan, Fatih

doi:10.1016/j.bjorl.2016.02.009

Cited by 37 publications

(29 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Ozbay et al found less vascular congestion and macrovacuolation in the ozone group. Similarly, Somay H et al found less vacuolization, vascular congestion, edema, hemorrhage and fibrosis after ozone therapy [6,21]. In the present study the characteristics of sciatic nerve specimens in the untreated group were similar to those of the treated group (Figure 4.g) except for an increased abundance of schwann cells and cytoplasmic organelles in the treated group.…”

Section: Medical Ozone Therapy Of Sciatic Nerve Cut Injurysupporting

confidence: 84%

“…This inadequacy caused by peripheral nerve injuries is related to the type of injury and repair method [1,5]. Oxidative stress can damage peripheric nerve regeneration and the process of repair after nerve cut injury [5][6][7]. The negative im-pacts of free oxygen radicals (FOR) on nerve regeneration can be decreased by antioxidants [7][8][9] Ozone therapy has been developed and it represents a recognized and efficient alternative treatment under specific clinical conditions [10] and has also been suggested as an immunomodulator and activator of cellular metabolism exhibiting long-term anti-inflammatory impacts [11].…”

Section: Introductionmentioning

confidence: 99%

“…Ozone therapy is considered to be an alternative safe and effective therapeutic method for oxygen metabolism, cellular energy, and antioxidant defense [9,14,16]. Ozbay et al [6], indicated that ozone therapy may be a promising alternative for the improvement of peripheric nerve injury [6]. The primary aim of this study is to determine the reliability of ozone therapy for peripheral nerve cut injury and evaluate its positive impacts by light and transmission electron microscope (TEM), motor, sensorial function tests, and biochemical analysis.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Neuroprotective Effects of Ozone Therapy After Sciatic Nerve Cut Injury

et al. 2018

View full text Add to dashboard Cite

A number of antioxidants have been used to treat peripheral nerve injury. However, there are few definitive experimental studies of ozone therapy for peripheral nerve cut injury. We aimed to examine the effects of mild level ozone therapy on sciatic nerve regeneration. One hundred adult male Wistar albino rats were randomly divided into four groups: group 1 (n=20) no cut injury or therapy; group 2 (n=20) sham; group 3 (n=30) nerve cut injury, no therapy; group 4 (n=30) nerve cut injury and ozone therapy. Sciatic functional index (SFI) and withdrawal reflex (WDR) were measured for all groups before nerve cut, at postoperative day 1, and at weeks 2, 4, 6 and 8. More myelinated (M) nerve fibers were observed after nerve cut injury in the ozone-therapy group. Significant differences were seen in plasma SOD (superoxide dismutase), CAT (catalase) and GPx (glutathione peroxidase) activities (p<0.05), and significant functional improvement was observed at postoperative weeks 2 and 4 (p<0.05) after ozone treatment. This is the first study conducted for the purpose of examining the effects of ozone therapy on sciatic nerve cut injury.

show abstract

Section: Medical Ozone Therapy Of Sciatic Nerve Cut Injurysupporting

confidence: 84%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Neuroprotective Effects of Ozone Therapy After Sciatic Nerve Cut Injury

et al. 2018

View full text Add to dashboard Cite

show abstract

“…In this study regeneration of the facial nerve was evaluated by assessing electrophysiological thresholds and by histopathological examination. This proves that ozonetherapy exerted beneficial effect on the regeneration of crushed facial nerves (Ozbay et al, 2016).…”

Section: Neurological Malfunctions (Facial Nerve Paralysis)supporting

confidence: 53%

An overview of ozone therapy in equine- an emerging healthcare solution

Bhatt¹,

Bhat²,

Dhama³

et al. 2016

JEBAS

View full text Add to dashboard Cite

The significance of ozone therapy has been increasingly realised in recent times particularly in equine medicine. The beneficial effects of ozone therapy are basically engendered by the mild oxidative stress it creates upon interacting with the extra-cellular and intracellular components. However therapeutic benefits of treatment could be obtained only when it is used within the therapeutic window. Higher doses may be counterproductive and lower doses ineffective. It is now well proved that it up regulates the antioxidant system of the patient and may provide relief from many chronic degenerative diseases upon prolonged use. Ozone therapy has shown encouraging results in the treatment of wide spectrum of diseases and disorders in equines including bacterial and viral infections. Obvious benefits of ozone therapy have been reported in Equine infectious anemia, chlamydial abortions, lymphomas and equine ehrlichiosis. This article provides an insight into the mechanism of action involved in ozone therapy and reviews various conditions which could be treated with the use of ozone therapy in equines.

show abstract

“…Regeneration and repair process follow nerve injury can be impaired due to the oxidative stress 1,2 . Antioxidants may alleviate the adverse effects of free oxygen radicals on nerve regeneration 3,4 .…”

Section: Introductionmentioning

confidence: 99%

Effect of ozone and methylprednisolone treatment following crush type sciatic nerve injury

et al. 2016

View full text Add to dashboard Cite

PURPOSE:To assess and compare the histopathological effects of ozone therapy and/or methylprednisolone (MPS) treatment on regeneration after crush type sciatic nerve injury. METHODS:Forty Sprague-Dawley male rats were randomly allocated into four groups. Four groups received the following regimens intraperitoneally every day for 14 days after formation of crush type injury on sciatic nerve: Group I: ozone (20mcg/ml); Group II: methylprednisolone (2mg/kg); Group III: ozone (20 mcg/ml) and methylprednisolone (2mg/kg); Group IV: isotonic saline (0.9%). The histomorphological evaluation was made after biopsies were obtained from the sites of injury.RESULTS: Significant differences were noted between groups in terms of degeneration (p=0.019), nerve sheath cell atrophy (p=0.012), intraneural inflammatory cellular infiltration (p=0.002), perineural granulation tissue formation (p=0.019), perineural vascular proliferation (p=0.004), perineural inflammatory cellular infiltration (p<0.001) and inflammation in peripheral tissue (p=0.006).Degeneration was remarkably low in Group III, while no change in nerve sheath cell was noted in Group II. CONCLUSION:The combined use of methylprednisolone and ozone treatment can have beneficial effects for regeneration after crush type nerve injury.

show abstract

Effects of ozone therapy on facial nerve regeneration

Abstract: We found that ozone therapy exerted beneficial effect on the regeneration of crushed facial nerves in rats.

Cited by 37 publications

References 28 publications

Neuroprotective Effects of Ozone Therapy After Sciatic Nerve Cut Injury

Neuroprotective Effects of Ozone Therapy After Sciatic Nerve Cut Injury

An overview of ozone therapy in equine- an emerging healthcare solution

Effect of ozone and methylprednisolone treatment following crush type sciatic nerve injury

Contact Info

Product

Resources

About