The effect of coenzyme Q and selenium on kidney in rats with partial unilateral ureteral obstruction

Kırdağ, Mustafa Koray; Tuglu, Devrim; Yuvanç, Ercan; Kısa, Üçler; Balcı, Mahi; Batı̇slam, Ertan; Yı́lmaz, Erdal

doi:10.5152/tud.2018.22556

Cited by 3 publications

(8 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Many studies revealed, Vitamin E therapy has renoprotective effects in animal UUO models and this vitamin could have some therapeutic significance to prevent the progression of renal fibrosis in human (5)(6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

“…Vitamin E and Selenium (Se) have a synergistic effect on lipid peroxidation mechanisms. Antioxidant trace element has an important role in GSH-Px-dependent mechanisms that protects cellular components from oxidative stress and damage (7). Selenium atoms are covalently bound to cysteine residues in GSH-Px have strong antioxidant properties, acts synergistically with vitamin E (7,9).…”

Section: Introductionmentioning

confidence: 99%

“…Many experimental studies have shown that selenium supplementation has an ability to prevent oxidant damage by reducing ROS activities. In renal damage, selenium intake has proven to be effective in improving selenium status and immune function (7,9). Some studies suggest, Vitamin E can be used in high doses for preventing oxidative damage (7,9).…”

Section: Introductionmentioning

confidence: 99%

“…In renal damage, selenium intake has proven to be effective in improving selenium status and immune function (7,9). Some studies suggest, Vitamin E can be used in high doses for preventing oxidative damage (7,9). Contrary, high doses of Vitamin E can occur with hemorrhagic stroke, ecchymosis and prolonged prothrombin time and may increase all-cause mortality.…”

Section: Introductionmentioning

confidence: 99%

“…Because of this risk, the recommended daily dose is 30 mg per day, and side-effects are usually experienced at doses above 1 g/kg. (7,8,10) We aimed to reveal what is the beneficial dose of Vitamin E and selenium in preventing renal damage. We planned to investigate the role of two different doses of Vitamin E with selenium in preventing renal damage due to unilateral ureteral obstruction (UUO).…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Effect of Different Doses of Vitamin E with Selenium on Renal Damage Caused by Unilateral Ureteral Obstruction Model?

Avcı¹,

Çil²,

Aybek³

et al. 2020

J Basic Clin Health Sci

View full text Add to dashboard Cite

Objective: Chronic kidney disease (CKD) is still common worldwide. We investigated the effect of two different doses of vitamin E with selenium (Se) administration to prevent CKD leads to renal damage via unilateral ureteral obstruction (UUO).Material and Methods: Thirty-two female Wistar Albino rats were divided into four groups; a sham group (left UUO+no medication); left UUO with no treatment, left UUO treated with 100 mg/kg dose Vitamin E+Se (RPVE+Se) and left UUO treated with 1000 mg/kg Vitamin E+Se (HDVE+Se) mixture. All rats subjected during 14 days and killed humanely. Malondialdehyde (MDA), superoxide dismutase (SOD), glutathione (GSH), levels were determined in kidney tissue, whereas total antioxidant status (TAS), total oxidant status (TOS) and DNA damage marker 8-hydroxy-2-deoxyguanosine (8-OHdG) in serum. Histologic examination were also done. Results:The unilateral ureteral obstruction model increased MDA (p<0.05), TOS (p<0.001) and 8-OHdG levels (p<0.001) via oxidative mechanisms. In the treatment groups increased TAS, SOD (p< 0.001), and GSH (p<0.001) levels were determined, but in RPVE+Se group, TAS levels were slightly higher than the HDVE+Se group (p=0,039). In terms of histological findings, tubular necrosis (p=0.003) and lymphocyte infiltration (p=0.002) were observed renal tissue images. RPVE+Se group findings were similar to the sham group, while in HDVE group these images similar to the UUO group. Conclusions:It was observed that UUO caused oxidative stress resulting in renal damage, and controlled vitamin E application with Selenium administration, which is considered to be an effective antioxidant couple, inhibited oxidative stress.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Effect of Different Doses of Vitamin E with Selenium on Renal Damage Caused by Unilateral Ureteral Obstruction Model?

Avcı¹,

Çil²,

Aybek³

et al. 2020

J Basic Clin Health Sci

View full text Add to dashboard Cite

show abstract

The effect of tannic acid on renal renin-angiotensin signaling pathway in a model of unilateral ureteral obstruction in male Wistar rats

Kianfar,

Kadkhodaee,

Seifi

et al. 2023

Naunyn-Schmiedeberg's Arch Pharmacol

View full text Add to dashboard Cite

Proliferative and apoptotic evaluations of renal preventive effects of coenzyme Q10 in radioiodine-131 induced renal damage

Yumuşak

Koca

Akbulut

et al. 2022

Ankara Üniversitesi Veteriner Fakültesi Dergisi

View full text Add to dashboard Cite

The aim of this study was to investigated anti-proliferative and antiapoptotic effects of coenzyme Q10 (CoQ10) in the prevention of radioiodine-131 (RAI) (I 131 ) induced kidney damage. A total of Wistar albino rats were separated into equal three groups (n = 8/group): Group 1 (control): untreated group; Group 2 (RAI): mCi/kg RAI oral route; Group 3 (RAI+CoQ10): 3 mCi/kg RAI oral route and intraperitoneally 30 mg/kg/day CoQ10. CoeQ10 treatment was started two days before RAI administration and was continued five days once daily after RAI.Pathomorphological parameters of kidneys were measured using hematoxylin-eosin and Masson's trichrome staining. Immunohistochemically; proliferating cell nuclear antigen (PCNA), caspase 8, caspase 9 and terminal deoxynucleotidyl transferasemediated deoxyuridine triphosphate nick end labeling (TUNEL) were used to determine proliferation and apoptosis. With the exception of the control group, varying degrees of inflammation, degeneration, necrosis, and interstitial/perivascular fibrosis were detected in the kidneys of all rats. This histopathological damage was found to be significantly less in CoQ10 group versus RAI group (P<0.05). The all immunohistochemical examinations demonstrated that administration of CoQ10 had reduced proliferation and apoptosis (P<0.05). The results of kidney histopathology and immunohistochemistry demonstrated that administration of CoQ10 had reduced inflammation, proliferation, and apoptosis. These findings show CoQ10 can play an important role in the radioprotection of kidneys against RAI-induced damage.

show abstract

The effect of coenzyme Q and selenium on kidney in rats with partial unilateral ureteral obstruction

Cited by 3 publications

References 22 publications

Effect of Different Doses of Vitamin E with Selenium on Renal Damage Caused by Unilateral Ureteral Obstruction Model?

Effect of Different Doses of Vitamin E with Selenium on Renal Damage Caused by Unilateral Ureteral Obstruction Model?

The effect of tannic acid on renal renin-angiotensin signaling pathway in a model of unilateral ureteral obstruction in male Wistar rats

Proliferative and apoptotic evaluations of renal preventive effects of coenzyme Q10 in radioiodine-131 induced renal damage

Contact Info

Product

Resources

About