The effect of cigarette smoke on the metabolism of arachidonic acid to myotropic compounds in rat and hamster isolated lungs

Uotila, Pekka; Männistö, Jussi

doi:10.1016/0161-4630(81)90114-2

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1982

1986

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Cited by 7 publications

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“…Metabolic function of various sub strates is influenced in the lung by expo sure to smoke [4,[10][11][12][13]. Using their iso lated perfused lung method, Bakhle et al [4] investigated the change in the conver sion rate of angiotensin 1 to angiotensin II in the rat.…”

Section: Discussionmentioning

confidence: 99%

Increase of Serum Angiotensin-Converting Enzyme Level after Exposure to Cigarette Smoke and Nicotine Infusion in Dogs

Sugiyama¹,

Yotsumoto²,

Takaku³

1986

Respiration

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Smoking is known to have various effects on metabolic function as well as on the respiratory function in the lung. We report here that exposure to smoke causes a rapid elevation of the level of serum angiotensin-converting enzyme in dogs in vivo. In 7 dogs, the level of serum angiotensin-converting enzyme increased from a basal level of 11.0 ± 5.0 to 13.9 ± 4.0 U/ml after 60 min of exposure (mean ± SD, p < 0.01). A similar elevation of serum angiotensin-converting enzyme level was noted in dogs that received an intravenous administration of nicotine. The possible mechanism of the change is discussed.

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