The effect of chronic vitamin deficiency and long term very low dose exposure to 6 pesticides mixture on neurological outcomes – A real-life risk simulation approach

Tsatsakis, Aristidis; Тышко, Н В; Docea, Anca Oana; Shestakova, S.I.; Sidorova, Yuliya S.; Петров, Н. А.; Zlatian, Ovidiu; Mach, Mojmı́r; Hartung, Thomas; Tutelyan, V A

doi:10.1016/j.toxlet.2019.07.026

Cited by 48 publications

(16 citation statements)

References 64 publications

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“…These findings are in accordance with the hormetic effects obtained by the studies that investigated the real-life exposure scenario to combination of stimuli that focus on 2 main characteristics: low doses and chronic exposure. [96][97][98][99] Finally, the present findings of a possible wide spectrum of beneficial effects suggest that epidemiological literature, which has consistently shown beneficial effects of the consumption of green tea, may be due to its hormetic effects. 39 The present findings should, therefore, be useful in hypothesis generation and testing and study design consideration for both experimental and epidemiological studies of green tea and its principal constituents.…”

Section: Discussionsupporting

confidence: 58%

Does Green Tea Induce Hormesis?

et al. 2020

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Green tea, and its principal constituent (–)-epigallocatechin-3-gallate (EGCG), are commonly shown to induce biphasic concentration/dose responses in a broad range of cell types, including non-tumor cells, and tumor cell lines. The most active area of research dealt with an assessment of neural cells with application to neurodegenerative diseases such as Parkinson’s disease and Alzheimer’s disease cell models, often using preconditioning experimental protocols. The general findings demonstrate EGCG-induced hormetic effects resulting in an enhanced acquired resilience within an adaptive and temporally dependent homeodynamic framework. The biphasic dose responses displayed the typical quantitative features of the hormetic dose response with respect to the amplitude and width of the stimulatory response. These findings provide further evidence for the general occurrence of hormetic dose responses with such responses being independent of the biological model, end point, inducing agent, and mechanism. The biphasic nature of these responses has important implications since it suggests optimal dose ranges for end points of public health and therapeutic applications. These findings indicate the need to assess the entire dose-response continuum in order to better define the nature of the dose response, especially in the low-dose zone where such exposures are common in human populations.

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Section: Discussionsupporting

confidence: 58%

Does Green Tea Induce Hormesis?

et al. 2020

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“…Real-life risk simulation (RLRS) strategies are powerful tools for assessing not only the toxicological implications of joint effects for several molecules, but also their collective beneficial role as nutraceuticals in our diet intake. These kinds of analyses are important, as studies which separately assess the cellular and metabolic effects of certain compounds can posit their detrimental or protective actions and their potency, and thus can lead to erroneous conclusions regarding their long-term habitual consumption in lower, non-pharmacological doses, but alongside numerous other chemicals (Hernandez et al, 2020;Margin� a et al, 2019;Tsatsakis et al, 2019b). This type of approach will certainly play an important part in one of the most important health struggles nowadays, the prevention of NCD, and could prove itself beneficial even in the context of the present viral outbreak, since inflammation is the key component of the severe phenomena associated with the COVID-19 respiratory complications.…”

Section: Discussionmentioning

confidence: 99%

Analysis of the intricate effects of polyunsaturated fatty acids and polyphenols on inflammatory pathways in health and disease

Margină

Ungurianu

Purdel

et al. 2020

Food and Chemical Toxicology

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Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre-including this research content-immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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“…Moreover, a new paradigm has emerged stating that real-life risk simulations of toxicological effects in humans should take into account long-term exposure with mixtures of synergistic chemicals at low doses (20)(21)(22). Several studies already showed the health risks ofter combined exposure to mixtures of xenobiotics after long-term, even if the doses for individual chemicals in the mixture are considered safe (23)(24)(25)(26)(27). High-intensity focused ultrasounds are used in association with other chemicals and this association in real-life cases can lead to unpredictive toxic effects that should be investigated.…”

Section: Discussionmentioning

confidence: 99%

Effect of ultrasound exposure on the Triticum aestivum root elongation test

et al. 2019

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The Triticum aestivum root elongation test can be used as a simple and effective method for the identification of novel potential anti-proliferative agents. The employment of this method is based on the fact that a significant number of oncogenic signal transduction pathways are highly conserved in living organisms. Moreover, the use of phytobiological assays has several advantages, such as rapid outcomes, simple procedure and reduced costs. Previous studies have demonstrated that ultrasound exposure can have lethal effects on small organisms, medium and high frequency exposure, leading to cell destruction. In the present study, the effects of ultrasound exposure on the radicular length of Triticum caryopses were analyzed as a potential tool for further experimentation using ultrasounds as a stress model in phytobiological tests. The influence of the exposure time was determined at different intervals and was proven to exert significant effects. Short intervals of <5 min produced no statistically significant effects on root elongation, and the maximum of inhibition was achieved following 30 min of exposure. The experimental results highlighted that the inhibitory effect of ultrasound irradiation was lower following 15 min of exposure than after a shorter interval of 10 min, emphasizing a complex, non-linear biological response. On the whole, the findings of this study indicated a complex mechanism for the inhibition of the radicular growth by ultrasound exposure. The ultrasound exposure of Triticum seeds may be used as a tool to either assess the effects of toxic agents following an increase in cell permeability, or to examine the synergistic action between ultrasounds and exposure to chemical mixtures that can promote physiological disruptions.

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The effect of chronic vitamin deficiency and long term very low dose exposure to 6 pesticides mixture on neurological outcomes – A real-life risk simulation approach

Cited by 48 publications

References 64 publications

Does Green Tea Induce Hormesis?

Does Green Tea Induce Hormesis?

Analysis of the intricate effects of polyunsaturated fatty acids and polyphenols on inflammatory pathways in health and disease

Effect of ultrasound exposure on the Triticum aestivum root elongation test

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