Does Green Tea Induce Hormesis?

Abstract

Green tea, and its principal constituent (–)-epigallocatechin-3-gallate (EGCG), are commonly shown to induce biphasic concentration/dose responses in a broad range of cell types, including non-tumor cells, and tumor cell lines. The most active area of research dealt with an assessment of neural cells with application to neurodegenerative diseases such as Parkinson’s disease and Alzheimer’s disease cell models, often using preconditioning experimental protocols. The general findings demonstrate EGCG-induced hormetic effects resulting in an enhanced acquired resilience within an adaptive and temporally dependent homeodynamic framework. The biphasic dose responses displayed the typical quantitative features of the hormetic dose response with respect to the amplitude and width of the stimulatory response. These findings provide further evidence for the general occurrence of hormetic dose responses with such responses being independent of the biological model, end point, inducing agent, and mechanism. The biphasic nature of these responses has important implications since it suggests optimal dose ranges for end points of public health and therapeutic applications. These findings indicate the need to assess the entire dose-response continuum in order to better define the nature of the dose response, especially in the low-dose zone where such exposures are common in human populations.

Polyphenols by Generating H2O2, Affect Cell Redox Signaling, Inhibit PTPs and Activate Nrf2 Axis for Adaptation and Cell Surviving: In Vitro, In Vivo and Human Health

“…This experiment demonstrates the possible hormetic effect of polyphenols/H 2 O 2 in cell signaling and its possibility to also act as a Distress compound. Most recently, just during the preparation of this review, Calabrese et al [141], by searching hormesis effects of polyphenols, confirmed our previous data and conclusions [13].…”

Hormesis and Ginseng: Ginseng Mixtures and Individual Constituents Commonly Display Hormesis Dose Responses, Especially for Neuroprotective Effects

“…metic dose response when sufficient conditioning doses are used in the experiment [5][6][7] rmetic dose responses are general, being independent of biological model, inducing agen point, level of biological organization, and mechanism [8]. A series of recent publications hav umented hormetic dose responses in the biomedical literature for curcumin [9], Ginkgo bilob ], and green tea [11]. The present findings show that ginseng-induced hormetic effects are als monly reported that are broadly generalizable, affecting numerous organ systems, cell types, an points, showing capacity to induce acquired resilience for various durations, within multiple an erse experimental settings, with particular research focus directed toward neuroprotective effect bles 1-3).…”

The Impact of Herbal Infusion Consumption on Oxidative Stress and Cancer: The Good, the Bad, the Misunderstood

“…Moreover, the inactivity of green tea polyphenols against superoxide free radicals may be due to high doses used, which resulted in a pro-oxidant toxic effect [ 252 ]. The main constituent of green tea, (−)-epigallocatechin-3-gallate, revealed biphasic dose-response on a broad range of cell types (non-tumor and tumor cell lines) [ 253 ].…”