The Effect of Chewing Gums Containing Calcium Phosphates on the Remineralization of Artificial Caries-Like Lesions in situ

Itthagarun, Anut; King, Nigel M.; Yiu, Cky

doi:10.1159/000084806

Cited by 35 publications

(26 citation statements)

References 21 publications

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“…From a methodology viewpoint, artificial lesion approaches have been extensively used to study caries as they show the same histological features as in natural caries and are easier to reproduce, making them highly suitable as a model to study remineralisation of enamel lesions [Kumar et al, 2008]. Single section lesions are sections of natural lesions [White, 1995], their utilisation allows accurate measurement of mineral changes within the lesions [White, 1995;Itthagarun et al, 2005]. The plaque formed in enamel sections is similar to the natural plaque from a microbiological and biochemical point of view [Itthagarun et al, 2005].…”

Section: Methodology To Assess Tooth Remineralisation Properties Of Cppsmentioning

confidence: 99%

“…Single section lesions are sections of natural lesions [White, 1995], their utilisation allows accurate measurement of mineral changes within the lesions [White, 1995;Itthagarun et al, 2005]. The plaque formed in enamel sections is similar to the natural plaque from a microbiological and biochemical point of view [Itthagarun et al, 2005]. When in situ studies are used as a prediction tool for subsequent in vivo human intervention trials, this allows a better control for product-unrelated variables [ten Cate, 1999].…”

Section: Methodology To Assess Tooth Remineralisation Properties Of Cppsmentioning

confidence: 99%

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Biofunctional Properties of Caseinophosphopeptides in the Oral Cavity

Nongonierma

Fitzgerald

2012

Caries Res

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Caseinophosphopeptides (CPPs), bioactive peptides released from caseins, have the ability to enhance bivalent mineral solubility. This is relevant to numerous biological functions in the oral cavity (promotion of tooth enamel remineralisation, prevention of demineralisation and buffering of plaque pH). Therefore, CPPs may play a positive role as prophylactic agents for caries, enamel erosion and regression of white spot lesions. Most in vitro and in situ studies demonstrate strong evidence for the bioactivity of CPPs in the oral cavity. Nevertheless, relatively little is known concerning their use as adjuvants for oral health and more particularly regarding their long-term effects on oral health.

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Section: Methodology To Assess Tooth Remineralisation Properties Of Cppsmentioning

confidence: 99%

Section: Methodology To Assess Tooth Remineralisation Properties Of Cppsmentioning

confidence: 99%

Biofunctional Properties of Caseinophosphopeptides in the Oral Cavity

Nongonierma

Fitzgerald

2012

Caries Res

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“…In a recent study, 12 volunteers wore intra-oral appliances all day long with specimens mounted lingually in the lower jaw and chewed 3 chewing gums containing urea [Itthagarun et al, 2005]. One of the chewing gums contained no calcium phosphate, one dicalcium phosphate and another one CPP-ACP.…”

Section: Discussionmentioning

confidence: 99%

Effects of Various Forms of Calcium Added to Chewing Gum on Initial Enamel Carious Lesions in situ

et al. 2007

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The purpose of this randomized, cross-over in situ study was to determine the effects of 4 chewing gums on artificial caries-like subsurface lesions. Two chewing gums (1 with zinc citrate and 1 without) contained dicalcium phosphate (3.9%), calcium gluconate (1.8%) and calcium lactate (0.45%), 1 chewing gum contained casein phosphopeptide-amorphous calcium phosphate nanocomplexes (0.7%), and another one contained no calcium. Fifteen subjects without current caries activity (7 male, 8 female; mean age: 27.5 ± 2.5 years) wore removable buccal appliances in the lower jaw with 4 bovine enamel slabs with subsurface lesions. The appliances were inserted immediately before gum chewing for 20 min and then retained for an additional 20 min. This was performed 4 times per day. Every subject chewed 4 different chewing gums over 4 periods of 14 days each. During a fifth period (control) the subjects only wore the appliances without chewing gum. At completion of each period the enamel slabs were embedded, sectioned and subjected to transversal microradiography. With regard to change of mineral loss and of lesion depth no significant differences could be found between chewing gums containing calcium and calcium-free chewing gums. Moreover, the chewing gum groups and the control group did not differ significantly if adjustments were made for baseline values (p > 0.05; ANCOVA). Under the conditions of the present study it may be concluded that the use of chewing gum offers no additional remineralizing benefit to buccal tooth surfaces, even if the chewing gum contains calcium compounds.

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“…The result of this analysis showed higher rates of tooth remineralization in favor of the use of CPP-ACP-based chewing gums, in comparison with the use of chewing gum without the addition of CPP-ACP, or in comparison with no intervention. Among the other 6 studies not included in the meta-analysis, 4 [12][13]15 were in situ studies, and all of them showed a higher rate of remineralization with the use of CPP-ACP. However, it is worth emphasizing that one of these studies 4 compared CPP-ACP added to fluoride in comparison with CPP-ACP alone and with Cai et fluoride alone, As a result, CPP-ACP associated with fluoride was observed to be the intervention that showed the best performance, while the intervention based on CPP-ACP only had a similar performance to that of fluoride alone.…”

Section: Systematic Reviewsmentioning

confidence: 99%

Efficacy of casein derivate CPP-ACP1

Pereira

Leal

2014

RGO, Rev. Gaúch. Odontol.

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RESUMO ObjetivoFoi conduzida revisão da literatura em busca de ensaios clínicos randomizados in situ e in vivo que avaliassem o papel do complexo de fosfopeptídeo de caseína -fosfato de cálcio amorfo na prevenção de lesões de cárie. MétodosInicialmente, buscou-se identificar na base Pubmed revisões sistemáticas sobre o tema. Foram identificadas duas revisões sistemáticas, que concluíram que a quantidade e qualidade dos ensaios clínicos randomizados são insuficientes para recomendação do uso clínico do produto. Posteriormente, pesquisaram-se ensaios clínicos randomizados in situ e in vivo que não tivessem sido incluídos nas revisões identificadas. ResultadosOs estudos in vivo e in situ tiveram resultados contraditórios. Os estudos in situ indicaram uma maior eficácia do complexo de fosfopeptídeo de caseína -fosfato de cálcio amorfo em relação ao placebo. Já os estudos in vivo demonstraram diferentes. ConclusãoComplexo de fosfopeptídeo de caseína -fosfato de cálcio amorfo apresentou desempenho ora superior, ora equivalente ao placebo; o flúor demonstrou maior eficácia que o complexo de caseína; o complexo de fosfopeptídeo de caseína -fosfato de cálcio amorfo associado ao flúor se mostrou ora melhor, ora equivalente ao placebo. Diante da evidência científica disponível, não se pode generalizar a indicação do complexo de fosfopeptídeo de caseína -fosfato de cálcio amorfo para prevenção de lesões cariosas.

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The Effect of Chewing Gums Containing Calcium Phosphates on the Remineralization of Artificial Caries-Like Lesions in situ

Cited by 35 publications

References 21 publications

Biofunctional Properties of Caseinophosphopeptides in the Oral Cavity

Biofunctional Properties of Caseinophosphopeptides in the Oral Cavity

Effects of Various Forms of Calcium Added to Chewing Gum on Initial Enamel Carious Lesions in situ

Efficacy of casein derivate CPP-ACP1

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