The effect of channel blocking on first spike timing

Effects of autapse and channel blockage on firing regularity in a biological neuronal network

“…In equation (1), GNa, GK and GL denote sodium, potassium and leakage ion channel conductance, respectively. In the model, the leakage conductance is constant, GL=0.3mScm -2 , whereas the others dynamically change as follows [30,34,37,38]:…”

“…For a given membrane, by a fine-tuned addition of these toxins a certain portion of potassium-and sodium ion channels could be disabled or blocked and hence the number of active (working) ion channels can be reduced. There are also plenty of studies based on different computational neuron models, where the impacts of changing the number of particular ion channels on firing dynamics of a single neuron or neuronal networks' is examined [30][31][32][33][34][35][36][37][38]. In these studies, it is uncovered that channel blocking has crucial impacts on firing dynamics.…”