The effect of cetirizine on symptoms and signs of nasal polyposis

Haye, Rolf; Aanesen, Jens P.; Burtin, Bernard; Donnelly, F.; Duby, Christian

doi:10.1017/s0022215100142422

Cited by 46 publications

(34 citation statements)

References 11 publications

(16 reference statements)

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“…As such there is some evidence that, in the context of CRS, antihistamines may provide some symptomatic relief when symptoms of allergic rhinitis such as frequent sneezing exist 46. There is, however, no evidence to support the routine use of antihistamines in CRS.…”

Section: Treatmentmentioning

confidence: 99%

Pathogenesis and treatment of chronic rhinosinusitis

Wood

Douglas

2010

Postgraduate Medical Journal

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Chronic rhinosinusitis (CRS) is one of the most common diseases in western societies, causing significant morbidity and resulting in great financial cost. Some patients suffer persistent or recurrent symptoms despite receiving optimal medical and surgical treatment. The recent publication of revised diagnostic criteria and management guidelines will assist both clinical research and practice. Multiple theories have been advanced regarding the underlying pathogenesis including allergy, bacterial or fungal infection, genetic predisposition and structural anomalies, but at present the majority of cases are still considered idiopathic. Recent studies have shown that traditional laboratory culture techniques may fail to detect microorganisms growing within biofilms or within host mucosal cells. Both bacteria and fungi possess a number of mechanisms for both the evasion and modulation of host immune responses, including the formation of biofilms and the production of superantigens. Historically, treatments such as antibiotics that had been directed at putative causative agents have often been disappointing. There are, however, a broad range of medical and surgical therapies with proven efficacy available to the treating physician. Endoscopic surgical management is evolving rapidly, and there have been pronounced improvements in outcome and reduction in the risk of complications. Recent advances in the understanding of the pathogenesis of this condition have led to some promising therapeutic developments, particularly in respect to topical treatments. Despite improvements in therapy, CRS remains a challenging condition to manage.

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Section: Treatmentmentioning

confidence: 99%

Pathogenesis and treatment of chronic rhinosinusitis

Wood

Douglas

2010

Postgraduate Medical Journal

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“…Cetirizine at a dose of 20 mg/day for 3 months significantly reduced sneezing, rhinorrhoea and obstruction compared with placebo in the postoperative treatment of recurrent polyposis but with no effect on polyp size [102]. However, antihistamines are recommended for those patients with nasal polyps associated with atopy.…”

Section: Antihistaminesmentioning

confidence: 99%

Controversies in the treatment of chronic rhinosinusitis

Guilemany

Alobid

Mullol

2010

Expert Review of Respiratory Medicine

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Chronic rhinosinusitis (CRS) including nasal polyps is a chronic inflammatory disease involving the mucosa of the nose and one or more paranasal sinuses. Despite differing hypotheses, the cause remains poorly understood. The key issue is the maintaining of ostial patency. CRS with nasal polyps is considered to be a subgroup of CRS. Major symptoms are nasal congestion or blockage, loss of smell, rhinorrhea, post-nasal drip, and facial pain or pressure. CRS is associated with lower airway disease such asthma, chronic obstructive pulmonary disease and bronchiectasis. In CRS with and without nasal polyps, medical treatment, including nasal and oral corticosteroids, is the first therapeutic option. The treatment of CRS still remains an unmet need. Corticosteroids are the mainstay of treatment and are the most effective drugs for treating airway inflammatory diseases such as asthma, allergic rhinitis and CRS. Endoscopic sinus surgery is only recommended when medical treatment fails. After surgery, medical treatment, including nasal and oral corticosteroids, is recommended.

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“…También logró un efecto beneficioso sobre la obstrucción nasal. Los efectos secundarios con 20 mg de cetirizina, el doble de la dosis diaria recomendada para adultos, fueron pocos y comparables con placebo 53 . Se puede concluir que el uso de antihistamínicos en pacientes con diagnóstico de RSCCP sólo es efectivo en manejar los síntomas derivados de la alergia, sin mostrar efectos en los pólipos, recomendándose su uso sólo en casos en los que la poliposis se asocie a sintomatología alérgica.…”

Section: Antihistamínicosunclassified

Distribución relativa de genotipos de virus papiloma humano en muestras de carcinoma escamoso de laringe

et al. 2009

Rev. Otorrinolaringol. Cir. Cabeza Cuello

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The effect of cetirizine on symptoms and signs of nasal polyposis

Cited by 46 publications

References 11 publications

Pathogenesis and treatment of chronic rhinosinusitis

Pathogenesis and treatment of chronic rhinosinusitis

Controversies in the treatment of chronic rhinosinusitis

Distribución relativa de genotipos de virus papiloma humano en muestras de carcinoma escamoso de laringe

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