The effect of carvacrol on the proinflammatory cytokines, histology, and fertility outcome of cisplatin-related ovarian change in a rat model

Dinc, Kemal; Ozyurt, Ramazan; Çoban, Taha Abdulkadir; Yazıcı, Gülce Naz; Süleyman, Zeynep; Yavuzer, Bulent; Süleyman, Halis

doi:10.1016/j.tjog.2022.11.011

Cited by 5 publications

(2 citation statements)

References 30 publications

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“…In the literature, it was shown that doxorubicin has negative effects on female reproductive system even in low doses [55]. Cisplatin has been shown to cause infertility and PDT [56].…”

Section: Discussionmentioning

confidence: 99%

The effect of Usnea longissima extract on chemotherapy-associated multi-organ damage in rats

Bingul,

Suleyman,

Mammadov

et al. 2023

Preprint

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The toxic effects of doxorubicin and cisplatin in various organs have been associated with oxidative stress. Studies have shown that Usnea longissima has strong antioxidant effects. The aim of this study was to investigate the protective effect of ethyl acetate extract from Usnea longissima (ULE), which is known to have strong antioxidant effects, on chemotherapeutic-induced heart, kidney, liver and ovarian toxicity. Albino Wistar female rats were divided into five groups (12 rats per group): healthy (HG), doxorubicin (DOX), Cisplatin (CIS), Doxorubicin + ULE (DULE), Cisplatin + ULE (CULE). In this experiment, ULE was given 100 mg/kg orally. After 1 hour, 2.5 mg/kg doxorubicin and 2.5 mg/kg cisplatin were administered intraperitoneally. Drug treatments continued once a day for seven days. At the end of seven days, six rats from each group were euthanised and heart, kidney, liver and ovary tissues were analysed biochemically. The remaining rats were left in the laboratory with male rats for 45 days for reproduction. ULE inhibited chemotherapeutic-induced increase in malondialdehyde, tumour necrosis factor alpha and interleukin 6 and decrease in total glutathione in liver, kidney and ovarian tissues. ULE also inhibited the increase of blood urea nitrogen, creatinine, alanine aminotransferase and aspartate aminotransferase in serum. ULE treatment had no protective effect against doxorubicin and cisplatin cardiac toxicity. On the other hand, ULE also decreased the delay in pregnancy induced by chemotherapy. ULE may be considered as adjuvant therapy in patients receiving chemotherapy to reduce liver, kidney and ovarian toxicity.

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“…In the literature, it was shown that doxorubicin has negative effects on female reproductive system even in low doses [55]. Cisplatin has been shown to cause infertility and PDT [56].…”

Section: Discussionmentioning

confidence: 99%

The effect of Usnea longissima extract on chemotherapy-associated multi-organ damage in rats

Bingul,

Suleyman,

Mammadov

et al. 2023

Preprint

Self Cite

View full text Add to dashboard Cite

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“…The effects of cisplatin on the reproductive system can also be investigated using animal models [35]. A recent model for cisplatin-induced ovarian toxicity was reported in the study by Dinc et al [90]. The negative effects of cisplatin in the ovaries of albino female Wistar rats were induced by a single daily dose of cisplatin (2.5 mg/kg) for 14 days.…”

Section: Overview Of Recent Relevant Animal Modelsmentioning

confidence: 99%

Oxidative Damage as a Fundament of Systemic Toxicities Induced by Cisplatin—The Crucial Limitation or Potential Therapeutic Target?

Katanić Stanković,

Selaković,

Rosić

2023

IJMS

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Cisplatin, an inorganic complex of platinum, is a chemotherapeutic drug that has been used for 45 years. Despite the progress of pharmaceutical sciences and medicine and the successful application of other platinum complexes for the same purpose, cisplatin is still the therapy of choice in many cancers. Treatment for testicular, ovarian, head and neck, urothelial, cervical, esophageal, breast, and pulmonary malignancies is still unthinkable without the use of this drug. However, cisplatin is also known for many side effects, of which the most pronounced are nephrotoxicity leading to acute renal failure, neurotoxicity, and ototoxicity. Mechanistic studies have proven that one of the conditions that plays a major role in the development of cisplatin-induced toxicities is oxidative stress. Knowing the fact that numerous antioxidants can be used to reduce oxidative stress, thereby reducing tissue lesions, organ failure, and apoptosis at the cellular level, many studies have defined antioxidants as a priority for investigation as a cotreatment. To investigate the mechanism of antioxidant action in vivo, many animal models have been employed. In the last few years, studies have mostly used rodents and zebrafish models. In this article, some of the most recent investigations that used animal models are listed, and the advantages and disadvantages of such experimental studies are pointed out.

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In vivo and In silico evidence of the protective properties of carvacrol against experimentally-induced gastric ulcer: Implication of antioxidant, anti-inflammatory, and antiapoptotic mechanisms

Badr

El-Orabi

Mahran

et al. 2023

Chemico-Biological Interactions

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The effect of carvacrol on the proinflammatory cytokines, histology, and fertility outcome of cisplatin-related ovarian change in a rat model

Cited by 5 publications

References 30 publications

The effect of Usnea longissima extract on chemotherapy-associated multi-organ damage in rats

The effect of Usnea longissima extract on chemotherapy-associated multi-organ damage in rats

Oxidative Damage as a Fundament of Systemic Toxicities Induced by Cisplatin—The Crucial Limitation or Potential Therapeutic Target?

In vivo and In silico evidence of the protective properties of carvacrol against experimentally-induced gastric ulcer: Implication of antioxidant, anti-inflammatory, and antiapoptotic mechanisms

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