The effect of carbon tetrachloride on the lipoproteins of rat-liver cell sap and serum

Abstract

1. The lipoproteins of the liver cell sap can be resolved by paper electrophoresis into five components. Almost two-thirds of the total lipid, cholesterol and phospholipid are present in the slowest- and the fastest-moving components. 2. There is a two- to three-fold increase in the lipid content of the liver cell sap after the administration of carbon tetrachloride. 3. The cholesterol and phospholipid contents of the serum alpha- and beta-lipoproteins separated by paper electrophoresis fall after treatment with carbon tetrachloride, whereas the total lipid content of that fraction that remains at the origin rises.

Study of soluble lipoprotein in rat liver mitochondria

“…Cellular lipoproteins can be classified into two groups: (i) insoluble lipoproteins of cellular and subcellular membranes; (ii) soluble lipoproteins such as those present in the intracellular fluid spaces of the cell cytoplasm. Bhargava & Sreenivasan (1966 have reported the presence of soluble lipoproteins in rat liver cell cytoplasm. The occurrence of soluble lipoprotein in rat liver nuclei is known (Levvi & Thomas, 1963;Wang, Mayer & Thomas, 1953).…”