Aspects of Lipid Metabolism in Ethanol-induced Fatty Liver

Marchetti, M.; Ottani, Vittoria; Zanetti, Paola; Puddu, Paolo

doi:10.1093/jn/95.4.607

Cited by 11 publications

(1 citation statement)

References 13 publications

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“…There is a wide variation in the hepatic ATP contents (0.278-1.49,tmol/g wet wt. of liver) reported in the literature for chow-fed rats (French, 1966;Hymans & Isselbacher, 1964;Marchetti, Ottani, Zanetti & Pudden, 1968). However, Schenker & O'Donnell (1965) have stressed that rapid freezing techniques and rapid analysis after extraction are prerequisites for accurate ATP determinations.…”

Section: Free Pimentioning

confidence: 99%

Biochemical aspects associated with an ethanol-induced fatty liver

Walker

Gordon

1970

Biochemical Journal

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Isocaloric replacement of either the fat or carbohydrate content of the diet by ethanol (36% of the total caloric intake) produced fatty infiltration of the liver in rats. The increase in hepatic triglyceride content was associated with a decrease in both ATP and glycogen contents. Increased activity of mitochondrial Mg(2+)-stimulated adenosine triphosphatase paralleled the increase in the free P(i) content of the liver homogenate. During the regression of the fatty liver, glycogen contents returned to normal within 24h of the removal of ethanol from the diet. Not until the third day after the withdrawal of ethanol had the Mg(2+)-stimulated adenosine triphosphatase activity and free P(i) content of the homogenate returned to normal. A slow regression of the triglyceride content from the liver occurred and by the fifth day both ATP and triglyceride concentrations had returned to the values observed in the rats given the liquid control diet.

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Section: Free Pimentioning

confidence: 99%