The Effect of Calendula Extract Toothpaste on the Plaque Index and Bleeding in Gingivitis

Amoian, Babak; Moghadamnia, Ali Akbar; Mazandarani, M; Amoian, M. M.; Mehrmanesh, S.

doi:10.3923/rjmp.2010.132.140

Cited by 16 publications

(26 citation statements)

References 33 publications

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“…It has been shown that calendula extract toothpaste could effectively reduce plaque and bleeding indexes in moderate to severe gingivitis. It has been suggested that anti-inflammatory, antibacterial and antioxidant properties of calendula may be responsible for mentioned effects on gingivitis [45]. On the other hand, it has been reported calendula flowers extract as an ointment is effective in relieving pain of cracked or tender nipples [46].…”

Section: Discussionmentioning

confidence: 99%

Antioxidant capacity of calendula officinalis flowers extract and prevention of radiation induced oropharyngeal mucositis in patients with head and neck cancers: a randomized controlled clinical study

et al. 2013

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This study was designed to determine the effect of Calendula officinalis flowers extract mouthwash as oral gel on radiation-induced oropharyngeal mucositis (OM) in patients with head-and-neck cancer. Forty patients with neck and head cancers under radiotherapy or concurrent chemoradiotherapy protocols were randomly assigned to receive either 2% calendula extract mouthwash or placebo (20 patients in each group). Patients were treated with telecobalt radiotherapy at conventional fractionation (200 cGy/fraction, five fractions weekly, 30–35 fractions within 4–7 weeks). The oropharyngeal mucositis was evaluated by two clinical investigators (a radiation oncologist and a dentist), using the oral mucositis assessment scale (OMAS). Trying to find out the possible mechanism of action of the treatment, total antioxidant, polyphenol and flavonoid contents, and quercetin concentration of the mouth wash were measured. Calendula mouthwash significantly decreased the intensity of OM compared to placebo at week 2 (score: 5.5 vs. 6.8, p = 0.019), week 3 (score: 8.25 vs. 10.95, p < 0.0001) and week 6 (score: 11.4 vs. 13.35, p = 0.031). Total antioxidant, polyphenol and flavonoid contents and quercetin concentration of the 2% extract were 2353.4 ± 56.5 μM, 313.40 ± 6.52 mg/g, 76.66 ± 23.24 mg/g, and 19.41 ± 4.34 mg/l, respectively. Calendula extract gel could be effective on decreasing the intensity of radiotherapy- induced OM during the treatment and antioxidant capacity may be partly responsible for the effect.

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Section: Discussionmentioning

confidence: 99%

Antioxidant capacity of calendula officinalis flowers extract and prevention of radiation induced oropharyngeal mucositis in patients with head and neck cancers: a randomized controlled clinical study

et al. 2013

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“…Furthermore, such products are a source of safer or more effective alternatives to synthetically produced antimicrobial agents (15).…”

Section: Introductionmentioning

confidence: 99%

Dentifrice Containing Extract of Rosmarinus officinalis Linn.: An Antimicrobial Evaluation

et al. 2016

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This study aimed to evaluate the antimicrobial activity of a dentifrice containing an alcoholic extract of rosemary on oral bacteria, compared to a commercially available herbal dentifrice. Standard strains of Streptococcus mutans (ATCC 25175), Streptococcus oralis (ATCC 9811) and Lactobacillus rhamnosus (ATCC 7469) were used, as well as different toothpastes based on rosemary (TR), on propolis (TH), triclosan (positive control) (TPC) and non-fluoridated dentifrice (negative control) (TNC). Bacteria were seeded in Petri dishes and paper discs soaked with dilutions of dentifrice placed on the plates. The inhibition halos were analyzed. It was observed that TR did not show statistical difference in relation to the TH to inhibit S. mutans and S. oralis, while TH was more active against L. rhamnosus. The toothpaste containing rosemary extract had the ability to inhibit the growth of S. mutans, S. oralis and L. rhamnosus, revealing an antimicrobial activity similar to commercially available toothpastes for inhibition of S. mutans and S. oralis.

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“…It can be recommended as an adjunct treatment to daily oral hygiene procedures. 33 A study demonstrated that the calendula flower extract possesses a high degree of antimicrobial activity against 18 different strains of anaerobic and facultative aerobic periodontal bacteria in vitro, suggesting that it may have an inhibitory effect on the bacteria causing pathogenesis of the supporting structures of the tooth. 34 In a in vitro study, it showed antifungal activity of calendula when compared to nystatin against different species of Candida including those causing oral candidiasis.…”

Section: Discussionmentioning

confidence: 99%

Calendula :- A Blooming Alternative Against Periopathogens

Yadav¹,

G.A²,

Prakash³

et al. 2017

IOSRJPBS

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The Effect of Calendula Extract Toothpaste on the Plaque Index and Bleeding in Gingivitis

Cited by 16 publications

References 33 publications

Antioxidant capacity of calendula officinalis flowers extract and prevention of radiation induced oropharyngeal mucositis in patients with head and neck cancers: a randomized controlled clinical study

Antioxidant capacity of calendula officinalis flowers extract and prevention of radiation induced oropharyngeal mucositis in patients with head and neck cancers: a randomized controlled clinical study

Dentifrice Containing Extract of Rosmarinus officinalis Linn.: An Antimicrobial Evaluation

Calendula :- A Blooming Alternative Against Periopathogens

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