The effect of caffeine on choroidal thickness in young healthy subjects

Zengin, Mehmet Özgür; Çınar, Esat; Karahan, Eyyüp; Tuncer, İbrahim; Küçükerdönmez, Cem

doi:10.3109/15569527.2014.912659

Cited by 33 publications

(25 citation statements)

References 20 publications

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“…Major systemic effects of caffeine include increased blood pressure, decreased heart rate, and reduced cerebral blood flow 13 . Caffeine additionally decreases retinal blood flow by increasing the resistivity factor of retinal vessels, and it has been shown that shortly after oral intake, caffeine causes a significant reduction in choroidal thickness 4, 14…”

Section: Discussionmentioning

confidence: 99%

“…Although very limited data are known about the pharmacokinetics of caffeine in ocular tissues, 2 several studies investigated the clinical effects of caffeine in the eye. Coffee was attributed to decreased ocular blood flow via constricting retinal arterioles and venules, 3 decreased choroidal thickness, 4 -although controversial-increased intraocular pressure (IOP), 5 and enlarged the pupils 6 …”

Section: Introductionmentioning

confidence: 99%

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The acute effects of single cup of coffee on ocular biometric parameters in healthy subjects

Uzun

Aslan

Öter

et al. 2019

Journal of Current Ophthalmology

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PurposeTo evaluate ocular biometric changes in healthy subjects after caffeine consumption from a cup of coffee.MethodsA total of 36 subjects were included in this prospective observational study. Axial length (AL) and anterior segment parameters including aqueous depth (AD), anterior chamber depth (ACD), lens thickness (LT), and central corneal thickness (CCT) were measured with optic biometry, Lenstar LS 900 (Haag-Streit, Inc., Koeniz, Switzerland) before and 1 and 4 h after ingesting a cup of coffee (60 mg caffeine/100 mL).ResultsMean age of the participants was 30.05 ± 7.43 years (range, 19–45). At baseline, 1st, and 4th hour, AL values were 23.9 ± 1.04 mm, 23.91 ± 1.04 mm, and 23.89 ± 1.04 mm, respectively, and no significant difference was observed (P>0.05). At baseline, 1st, and 4th hour, AD values were 3.06 ± 0.3 mm, 3.11 ± 0.3 mm, and 3.09 ± 0.3 mm, and ACD values were 3.6 ± 0.32, 3.66 ± 0.31, and 3.64 ± 0.31, respectively. AD and ACD values were significantly greater than baseline at 1st and 4th hours following coffee ingestion. Coffee intake caused a significant reduction in LT, compared with baseline and at the 1st and 4th hours which were 3.76 ± 0.28 mm, 3.69 ± 0.32 mm, and 3.72 ± 0.27 mm, respectively. No statistically significant difference was determined in between the 3 measurements in terms of CCT (P>0.05).ConclusionCaffeine causes a significant increase in AD and ACD and a significant decrease in LT following oral intake, for at least 4 h.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The acute effects of single cup of coffee on ocular biometric parameters in healthy subjects

Uzun

Aslan

Öter

et al. 2019

Journal of Current Ophthalmology

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“…Three consecutive scans were performed, at the same time of day on three separate days, to control for diurnal variations in choroidal structure. 25 , 26 Moreover, participants were advised to avert caffeine 27 , 28 and nicotine 29 at least 1 hour prior to the measurement to avoid short-term changes of ChT. In order to wash out near work-induced accommodative choroidal thinning 30 , 31 and to stabilize blood pressure, 26 participants completed a 10-minute resting phase with distance viewing.…”

Section: Methodsmentioning

confidence: 99%

Choroidal Biomarkers: A Repeatability and Topographical Comparison of Choroidal Thickness and Choroidal Vascularity Index in Healthy Eyes

Breher

Terry

Bower

et al. 2020

Trans. Vis. Sci. Tech.

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Purpose Choroidal thickness (ChT) and choroidal vascularity index (CVI) represent two important metrics in health-, disease-, and myopia-related studies. Wide-field swept-source optical coherence tomography (OCT) provides improved and extended imaging and extraction of choroidal variables. This study characterizes the topography and repeatability of these parameters in healthy eyes. Methods Swept-source OCT volume scans were obtained on 14 young adult patients on three separate days. ChT and CVI were automatically corrected for image magnification and extracted for different enface regions within an extended ETDRS grid of 10 mm diameter. Topographical distribution, correlation to ocular length, and intersession repeatability of both choroidal parameters were assessed. Results CVI showed little fluctuation between subfields, unlike ChT, which demonstrated thinning toward the peripheral choroid (coefficients of variation 5.92 vs. 0.89). ChT showed a consistent negative correlation with axial length (ρ = −0.05 to −0.61), although this was only statistically significant in the inner superior subfield ( P = 0.02). There was no consistent or significant relationship between CVI and axial length or between CVI and ChT. The repeatability of CVI measurements (3.90%–5.51%) was more consistent between scan regions than ChT measurements (10.37–20.33 µm). Conclusions CVI values were consistent across the central 10 mm of the retina, while ChT reduced with eccentricity. The repeatability of both parameters is similar to the effect size reported in many studies using the choroid as a biomarker, which should be considered in the interpretation of findings. Translational Relevance This study provided normative as well as metrological information for the clinical interpretation of ChT and CVI in health and disease.

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“…[ 5 6 ] Previous studies have also reported that measurements of CT have been decreased after caffeine intake and topical mydriatics. [ 7 8 9 ]…”

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confidence: 99%

Choroidal thickness changes after dynamic exercise as measured by spectral-domain optical coherence tomography

Sayın

Kara

Pekel

et al. 2015

Indian J Ophthalmol

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Purpose:To measure the choroidal thickness (CT) after dynamic exercise by using enhanced depth imaging optical coherence tomography (EDI-OCT).Materials and Methods:A total of 19 healthy participants performed 10 min of low-impact, moderate-intensity exercise (i.e., riding a bicycle ergometer) and were examined with EDI-OCT. Each participant was scanned before exercise and afterward at 5 min and 15 min. CT measurement was taken at the fovea and 1000 μ away from the fovea in the nasal, temporal, superior, and inferior regions. Retinal thickness, intraocular pressure, ocular perfusion pressure (OPP), heart rate, and mean blood pressure (mBP) were also measured.Results:A significant increase occurred in OPP and mBP at 5 min and 15 min following exercise (P ˂ 0.05). The mean subfoveal CT at baseline was 344.00 ± 64.71 μm compared to 370.63 ± 66.87 μm at 5 min and 345.31 ± 63.58 μm at 15 min after exercise. CT measurements at all locations significantly increased at 5 min following exercise compared to the baseline (P ˂ 0.001), while measurements at 15 min following exercise did not significant differ compared to the baseline (P ˃ 0.05). There was no significant difference in retinal thickness at any location before and at 5 min and 15 min following exercise (P ˃ 0.05).Conclusion:Findings revealed that dynamic exercise causes a significant increase in CT for at least 5 min following exercise.

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The effect of caffeine on choroidal thickness in young healthy subjects

Abstract: Caffeine causes a significant decrease in choroidal thickness following oral intake. This decrease might be a result of reduced ocular blood flow due to its vasoconstrictive effect.

Cited by 33 publications

References 20 publications

The acute effects of single cup of coffee on ocular biometric parameters in healthy subjects

The acute effects of single cup of coffee on ocular biometric parameters in healthy subjects

Choroidal Biomarkers: A Repeatability and Topographical Comparison of Choroidal Thickness and Choroidal Vascularity Index in Healthy Eyes

Choroidal thickness changes after dynamic exercise as measured by spectral-domain optical coherence tomography

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