The acute effects of single cup of coffee on ocular biometric parameters in healthy subjects

Abstract

PurposeTo evaluate ocular biometric changes in healthy subjects after caffeine consumption from a cup of coffee.MethodsA total of 36 subjects were included in this prospective observational study. Axial length (AL) and anterior segment parameters including aqueous depth (AD), anterior chamber depth (ACD), lens thickness (LT), and central corneal thickness (CCT) were measured with optic biometry, Lenstar LS 900 (Haag-Streit, Inc., Koeniz, Switzerland) before and 1 and 4 h after ingesting a cup of coffee (60 mg caffeine/100 mL).ResultsMean age of the participants was 30.05 ± 7.43 years (range, 19–45). At baseline, 1st, and 4th hour, AL values were 23.9 ± 1.04 mm, 23.91 ± 1.04 mm, and 23.89 ± 1.04 mm, respectively, and no significant difference was observed (P>0.05). At baseline, 1st, and 4th hour, AD values were 3.06 ± 0.3 mm, 3.11 ± 0.3 mm, and 3.09 ± 0.3 mm, and ACD values were 3.6 ± 0.32, 3.66 ± 0.31, and 3.64 ± 0.31, respectively. AD and ACD values were significantly greater than baseline at 1st and 4th hours following coffee ingestion. Coffee intake caused a significant reduction in LT, compared with baseline and at the 1st and 4th hours which were 3.76 ± 0.28 mm, 3.69 ± 0.32 mm, and 3.72 ± 0.27 mm, respectively. No statistically significant difference was determined in between the 3 measurements in terms of CCT (P>0.05).ConclusionCaffeine causes a significant increase in AD and ACD and a significant decrease in LT following oral intake, for at least 4 h.

The effect of systemic and topical ophthalmic medications on choroidal thickness: A review

“…This finding was consistent across different caffeine dosages including 200, 58,59,61 60 62 and 57 mg 60 . Caffeine causes retinal vasoconstriction by antagonizing adenosine receptors, 62 and could potentially cause vasoconstriction in the choroid through a similar mechanism 94 . No adverse reactions specific to the choroid have been reported.…”

“…Caffeine can be administered occasionally or chronically. Caffeine intake causes a significant decrease in CT lasting at least 3–4 hours and returning to baseline after 6 hours 58–62 . This finding was consistent across different caffeine dosages including 200, 58,59,61 60 62 and 57 mg 60 .…”

“…Caffeine intake causes a significant decrease in CT lasting at least 3–4 hours and returning to baseline after 6 hours 58–62 . This finding was consistent across different caffeine dosages including 200, 58,59,61 60 62 and 57 mg 60 . Caffeine causes retinal vasoconstriction by antagonizing adenosine receptors, 62 and could potentially cause vasoconstriction in the choroid through a similar mechanism 94 .…”

“…Caffeine intake causes a significant decrease in CT lasting at least 3–4 h and returning to baseline after 6 h 58–62 …”

“…50 Of note, the duration of therapy was shorter in the 2 studies, finding no difference in CT (45 min 10 and 1 mo), 51 compared to the study finding a significant increase (3 mo 50 ). ) Caffeine intake causes a significant decrease in CT lasting at least 3-4 h and returning to baseline after 6 h [58][59][60][61][62] Ethanol causes a transient SFCT increase that normalized 120 min after intake.…”