Effects of caffeine intake on the biomechanical properties of the cornea: a placebo-controlled, double-blind, crossover pilot study in low caffeine consumers

Jiménez, Raimundo; Molina, Rubén; Redondo, Beatríz; Vera, Jesús

doi:10.1007/s00417-020-04835-0

Cited by 3 publications

(2 citation statements)

References 51 publications

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“…As a consequence, from the disturbed state by each air puff, the cornea firstly flattens (inward applanation), reaching the highest concavity, and again undergoes another applanation state (outward applanation) before becoming fully restored to its normal state. The CorVis ST provides a number of parameters, and for this study, we considered the time of the first and second applanations (A1T and A2T, respectively), the length of the first and second applanations (A1L and A2L, respectively), the amplitude of the first and second applanations (A1D and A2D, respectively), the velocity of the first and second applanations (A1V and A2V, respectively), the deformation amplitude at the highest concavity (HCDA), the time to highest concavity (HCT), the highest concavity curvature (HCR) and the peak distance (PD) (see Jiménez et al [ 15 ] for a description of these measurements).…”

Section: Methodsmentioning

confidence: 99%

“…There is a relationship between alterations in corneal biomechanics and different factors and ocular parameters such as age [ 12 , 13 ], diabetes [ 14 ], caffeine intake [ 15 ], hormonal changes [ 16 ], level of hydration and fasting [ 17 ], exposure to ultraviolet radiation [ 18 ], intraocular pressure (IOP) [ 13 , 19 ], refractive error [ 20 ], axial length [ 13 ], corneal central thickness and corneal curvature [ 13 ], ocular surgery [ 9 , 10 , 21 ] or orthokeratology [ 22 , 23 ] among others.…”

Section: Introductionmentioning

confidence: 99%

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The short-term effects of wearing swimming goggles on corneal biomechanics

et al. 2022

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Purpose This study aimed to assess the impact of wearing swimming goggles (SG) on corneal biomechanics. Methods Corneal deformation response, central corneal thickness (CCT), intraocular pressure (IOP) and biomechanically corrected intraocular pressure (bIOP) were measured with the Corvis system (Oculus Optikgeräte GmbH, Wetzlar, Germany) in thirty-one healthy young adults while wearing a drilled SG. All measurements were obtained before, at 30 s, 2 min, 3.5 min and 5 min of wearing SG, just after SG removal and after 2 min of SG removal. Results The corneal biomechanics is sensitive to SG wear, observing lower corneal deformability during SG use. Specifically, wearing SG caused an increase in the time and length of the first applanation and radius curvature at the highest concavity, as well as a decrease and in the velocity of the first applanation and time and deformation amplitude of the second applanation (p < 0.001 in all cases). After SG removal, corneal biomechanical parameters showed a rebound-effect, obtaining a higher corneal deformability in comparison with baseline reading (p-corrected < 0.05 in all cases). Additionally, IOP and bIOP significantly increased while wearing SG (p < 0.001 in both cases), whereas CCT remained stable (p = 0.850). Conclusions Wearing SG modifies the biomechanical properties of the cornea, with reduced corneal deformability during SG wear. The outcomes of this study should be taken into consideration when making clinical decisions in subjects at high risk of developing corneal ectasias or glaucoma, as well as in the post-surgical management of these ocular conditions.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The short-term effects of wearing swimming goggles on corneal biomechanics

et al. 2022

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TFOS Lifestyle: Impact of nutrition on the ocular surface

et al. 2023

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Comparisons of corneal biomechanical and higher-order aberrations between thin normal cornea and Forme Fruste keratoconus

Liu,

Liu

et al. 2024

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Background To compare the corneal biomechanical parameters and higher-order aberrations (HOAs) of thin normal cornea (TNC) and Forme Fruste keratoconus (FFKC). Methods The data collected between June 2018 and May 2023 at the Eye Hospital Affiliated with Shandong First Medical University were divided into two groups: 26 normal eyes of 26 patients (18–38 years) with the thinnest corneal thickness (TCT) ≤ 500 µm and 26 eyes of 26 patients (14–35 years) with FFKC. Central corneal thickness (CCT) and biomechanical-corrected intraocular pressure (bIOP) were matched by propensity score matching. Scheimpfug imaging (Pentacam) and corneal visualization Scheimpfug technology (Corvis ST) were used to compare the variations in corneal biomechanical parameters and HOAs between the two groups. The receiver operating characteristic (ROC) curve was used to judge the accuracy of significantly different parameters in predicting FFKC. The FFKC diagnostic model was established using the best discriminant function. Results The time of the first applanation (A1T), the velocity of corneal movement during the second applanation (A2V), the time at which the cornea reached the highest concavity (HCT) and the total corneal root mean square (RMS) of the HOA were significantly different between the two groups (P < 0.05). HCT showed good potential for distinguishing between FFKC and TNC. The best discriminant function showed a prediction accuracy of 78.4%. Conclusion This study suggested that the relationship between certain biomechanical properties and HOAs could be valuable for the diagnosis of FFKC.

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Effects of caffeine intake on the biomechanical properties of the cornea: a placebo-controlled, double-blind, crossover pilot study in low caffeine consumers

Cited by 3 publications

References 51 publications

The short-term effects of wearing swimming goggles on corneal biomechanics

The short-term effects of wearing swimming goggles on corneal biomechanics

TFOS Lifestyle: Impact of nutrition on the ocular surface

Comparisons of corneal biomechanical and higher-order aberrations between thin normal cornea and Forme Fruste keratoconus

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