The Effect of Caffeine and Rhodiola Rosea, Alone or in Combination, on 5-km Running Performance in Men

Duncan, Michael; Tallis, Jason; Wilson, Susie; Clarke, Neil D.

doi:10.1089/jcr.2015.0025

Cited by 7 publications

(10 citation statements)

References 26 publications

(3 reference statements)

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“…Consuming a combination of RHO and CAF can improve the performance of male recreational exercisers in the 5 km running time trial [ 74 ]. Therefore, in this study, we identified the combination of CAF+RHO can produce better physical performance-boosting effects than either alone, and we further investigated the potential mechanisms for this process.…”

Section: Discussionmentioning

confidence: 99%

Synergistic Effect of Rhodiola rosea and Caffeine Supplementation on the Improvement of Muscle Strength and Muscular Endurance: A Pilot Study for Rats, Resistance Exercise-Untrained and -Trained Volunteers

et al. 2023

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Multi-level studies have shown that Rhodiola rosea (RHO) and Caffeine (CAF) have the potential to be nutritional supplements to enhance physical performance in resistance exercise-untrained and -trained subjects. This study examined the synergistic effects of RHO (262.7 mg/kg for rats and 2.4 g for volunteers) and CAF (19.7 mg/kg for rats and 3 mg/kg for volunteers) supplementation on improving physical performance in rats, resistance exercise-untrained volunteers and resistance exercise-trained volunteers. Rats and volunteers were randomly grouped into placebo, CAF, RHO and CAF+RHO and administered accordingly with the nutrients during the training procedure, and pre- and post-measures were collected. We found that RHO+CAF was effective in improving forelimb grip strength (13.75%), erythropoietin (23.85%), dopamine (12.65%) and oxygen consumption rate (9.29%) in the rat model. Furthermore, the current results also indicated that the combination of RHO+CAF significantly increased the bench press one-repetition maximum (1RM) (16.59%), deep squat 1RM (15.75%), maximum voluntary isometric contraction (MVIC) (14.72%) and maximum repetitions of 60% 1RM bench press (22.15%) in resistance exercise-untrained volunteers. Additionally, despite the excellent base level of the resistance exercise-trained volunteers, their deep squat 1RM and MVIC increased substantially through the synergistic effect of RHO and CAF. In conclusion, combined supplementation of RHO+CAF is more beneficial in improving the resistance exercise performance for both resistance exercise-untrained and -trained volunteers. The present results provide practical evidence that the synergies of RHO and CAF could serve as potential supplementary for individuals, especially resistance exercise-trained subjects, to ameliorate their physical performances effectively and safely.

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Section: Discussionmentioning

confidence: 99%

Synergistic Effect of Rhodiola rosea and Caffeine Supplementation on the Improvement of Muscle Strength and Muscular Endurance: A Pilot Study for Rats, Resistance Exercise-Untrained and -Trained Volunteers

et al. 2023

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“…Literature search. Over the past two decades, more than a dozen clinical trials have examined the effects of RR on exercise performance and adaptations (Table 1) (23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39) . To ensure this narrative review accurately represents the current body of scientific evidence, searches were performed using several electronic databases (PubMed®, Web of Science TM and Scopus), with screening of relevant articles to identify research reporting the effects of RR on exercise performance and related outcomes in humans.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Eight of the clinical studies identified included bicycle ergometry as an exercise testing modality, and the specific protocols varied widely (23,24,25,28,29,30,35,36) . Three trials included running, either on a treadmill (33,37) or as a marathon race (31,32) , one trial employed walking on a treadmill in a climate chamber (34) , one trial used rowing ergometry (27) and three trials incorporated resistance exercise, including wrist flexion (26) , bench press (38,39) and/or squat exercises (39) .…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Collectively, based on a recent Participation Classification Framework (40) , most participants likely fell within the tier 1 (recreationally active) or tier 2 (trained/developmental) categories, with the possibility of some untrained participants falling within tier 0 (sedentary) (24,39) and some highly trained participants belonging to tier 3 (highly trained/national level) (27) . Six studies used acute RR supplementation protocols (26,29,30,33,36,38) , defined here as 1-7 d of supplementation, nine implemented chronic supplementation (>7 d; range 8-38 d) (23,24,27,28,31,32,34,37,39) and one incorporated both acute and chronic supplementation strategies (25) . Daily doses of RR ranged from 100 to 2400 mg/d.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…A few clinical studies have investigated outcomes related to energy metabolism. For instance, RR supplementation has been found to increase (38) , decrease (28) or exert no discernible influence (27,29,33,34,37) on post-exercise lactate concentrations compared with placebo. The sole study reporting an increase in lactate concentrations with supplementation used resistance training in resistance-trained males (38) , while the only trial indicating a decrease in post-exercise lactate included cycling to exhaustion in male athletes (28) .…”

Section: Energy Systemsmentioning

confidence: 99%

See 2 more Smart Citations

Rhodiola rosea as an adaptogen to enhance exercise performance: a review of the literature

Tinsley,

Jagim,

Potter

et al. 2023

Br J Nutr

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Rhodiola rosea (RR) is a plant whose bioactive components may function as adaptogens, thereby increasing resistance to stress and improving overall resilience. Some of these effects may influence exercise performance and adaptations. Based on studies of rodents, potential mechanisms for the ergogenic effects of RR include modulation of energy substrate stores and use, reductions in fatigue and muscle damage, and altered antioxidant activity. At least 16 investigations in humans have explored the potential ergogenicity of RR. These studies indicate acute RR supplementation (∼200 mg RR containing ∼1% salidroside and ∼3% rosavin, provided 60 minutes before exercise) may prolong time-to-exhaustion and improve time trial performance in recreationally active males and females, with limited documented benefits of chronic supplementation. Recent trials providing higher doses (∼1,500 to 2,400 mg RR/day for 4 to 30 days) have demonstrated ergogenic effects during sprints on bicycle ergometers and resistance training in trained and untrained adults. The effects of RR on muscle damage, inflammation, energy system modulation, antioxidant activity, and perceived exertion are presently equivocal. Collectively, it appears that adequately dosed RR enhances dimensions of exercise performance and related outcomes for select tasks. However, the current literature does not unanimously show that RR is ergogenic. Variability in supplementation dose and duration, concentration of bioactive compounds, participant characteristics, exercise tests, and statistical considerations may help explain these disparate findings. Future research should build on the longstanding use of RR and contemporary clinical trials to establish the conditions in which supplementation facilitates exercise performance and adaptations.

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An Overview on Rhodiola rosea in Cardiovascular Health, Mood Alleviation, and Energy Metabolism

Duncan

Clarke

2017

Sustained Energy for Enhanced Human Functions and Activity

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The Effect of Caffeine and Rhodiola Rosea, Alone or in Combination, on 5-km Running Performance in Men

Cited by 7 publications

References 26 publications

Synergistic Effect of Rhodiola rosea and Caffeine Supplementation on the Improvement of Muscle Strength and Muscular Endurance: A Pilot Study for Rats, Resistance Exercise-Untrained and -Trained Volunteers

Synergistic Effect of Rhodiola rosea and Caffeine Supplementation on the Improvement of Muscle Strength and Muscular Endurance: A Pilot Study for Rats, Resistance Exercise-Untrained and -Trained Volunteers

Rhodiola rosea as an adaptogen to enhance exercise performance: a review of the literature

An Overview on Rhodiola rosea in Cardiovascular Health, Mood Alleviation, and Energy Metabolism

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