The effect of caffeic acid phenethyl ester on ischemia-reperfusion injury in comparison with α -tocopherol in rat kidneys

Irmak, M. Kemal; Koltuksuz, Uğur; Kutlu, Nurettin Onur; Yagmurca, Murat; Özyurt, Hüseyın; Karaman, Abdurrahman; Akyol, Ömer

doi:10.1007/s002400100185

Cited by 111 publications

(79 citation statements)

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“…[5,23] Unal et al [5] observed that vitamin C+E had some antioxidative effects on the reperfusion injury, though a statistically significant, positive effect could not be demonstrated in the histopathological evaluations. Also Irmak et al [23] studied the effect of caffeic phenethyl ester (CAPE) on ischemiareperfusion in comparison with vitamin E. Morphological damage was clearly observed in the kidneys of the IR group. They reported that CAPE but not vitamin E apparently reduced the renal tissue damage.…”

Section: Discussionmentioning

confidence: 99%

The Protective Effects of Melatonin and Vitamin E against Renal Ischemia-Reperfusion Injury in Rats

et al. 2007

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Reactive oxygen species (ROS) were shown to contribute to the cellular damage induced by ischemia-reperfusion. The purpose of this study was to investigate and compare the efficiency of melatonin and vitamin E in the reduction of injury induced by ROS in a rat model of renal ischemia-reperfusion. Twenty-four Wistar-albino rats were divided into four groups. Rats in the Sham group were given saline 1 mL/kg, intraperitoneally (ip) 72 h, 48 h, 24 h, and 30 min before the sham operation. Rats in ischemia-reperfusion (IR), IR+Melatonin, and IR+Vitamin E groups were given saline (1 mL/ kg), melatonin (10 mg/kg), and vitamin E (100 mg/kg) ip, respectively, 72 h, 48 h, 24 h, and 30 min before the ischemia for 60 min, followed by reperfusion for 60 min. The blood samples and kidney tissues of the rats were taken under anesthesia. Ischemia-reperfusion significantly increased urea, creatinine, and malondialdehyde (MDA) levels, and decreased superoxide dismutase (SOD) and catalase (CAT) activities. Histopathological findings of the IR group confirmed that there was renal impairment by cast formation and tubular necrosis in the tubular epithelium. In the IR+Melatonin group, while MDA levels significantly decreased, SOD activities increased. In the IR+Melatonin group, the level of tubular necrosis and cast formation are significantly decreased than those seen in the ischemia-reperfusion group. Melatonin in particular was effective to reverse hot ischemia of kidney by its antioxidant effects. These results may indicate that melatonin pretreatment protects against functional, biochemical, and morphological damage better than vitamin E in renal ischemia-reperfusion injury.

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Section: Discussionmentioning

confidence: 99%

The Protective Effects of Melatonin and Vitamin E against Renal Ischemia-Reperfusion Injury in Rats

et al. 2007

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“…21 Protein measurements were analyzed in homogenate and supernatant samples according to the method explained elsewhere.…”

Section: Tissue Preparations For Analysesmentioning

confidence: 99%

Prevention of renal ischemia/reperfusion‐induced injury in rats by leflunomide

Karaman

Türkmen²,

Gürsul

et al. 2006

Int J of Urology

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Objective: There is increasing evidence to suggest that toxic oxygen radicals play an essential role in the pathogenesis of ischemia/ reperfusion (I/R) injury in the kidney. This study was designed to investigate the effects of leflunomide, an isoxazole derivative and a unique immunomodulatory agent, in I/R-induced renal injury in rats. Methods: Forty female Sprague-Dawley rats were divided equally into four groups: (I) control (only leflunomide 10 mg/kg, intragastrically treated); (II) sham operated (only unilateral nephrectomy); (III) I/R; and (IV) leflunomide (10 mg/kg for two doses prior to experiment) plus I/R groups. In groups III and IV, after unilateral nephrectomy, the rats were subjected to 60 min of left renal pedicle occlusion, followed by 6 h of reperfusion. At the end of the reperfusion period, rats were killed and kidneys and blood were removed. Catalase, myeloperoxidase and xanthine oxidase activities, and malondialdehyde, nitric oxide and protein carbonyl levels were determined in renal tissue. Serum creatinine, blood urea nitrogen and aspartate aminotransferase were measured for the evaluation of renal function. In histopathological examination, renal damage was scored 0-3. Results: Group III animals demonstrated severe deterioration of renal function, renal morphology and a significant renal oxidative stress. Pretreatment of animals with leflunomide markedly attenuated renal dysfunction, morphological alterations, reduced elevated oxidative stress products levels and restored the depleted renal antioxidant enzyme. Conclusion:The findings imply that oxygen radicals play a causal role in I/R-induced renal injury, and leflunomide exerts renoprotective effects probably by the radical scavenging and antioxidant activities with immunomodulatory effect.

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“…CAPE can completely block the production of reactive oxygen species (ROS) in human neutrophils and in the xanthine/xanthine oxidase (XO) system at a concentration of 10 μmol (12). In the previous studies it has been shown that CAPE preserves heart tissue from isoproterenol-induced cardiac damage and restores the impaired antioxidant enzyme activity in the rat kidney and heart (13)(14)(15)(16)(17). Furthermore, it was reported that CAPE (10 μmol/kg) application significantly reversed the increased MDA, decreased NO levels and the increased diameters of myocardial myofibrils in cadmium-induced hypertensive rats (11).…”

Section: Introductionmentioning

confidence: 99%

The effect of caffeic acid phenethyl ester on isoproterenol-induced myocardial injury in hypertensive rats

İlhan¹,

Yılmaz²,

Nacar³

et al. 2014

Anadolu Kardiyol Derg

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Objective: The aim of this study is to investigate the effects of caffeic acid phenethyl ester (CAPE) on isoproterenol (ISO)-induced myocardial injury in hypertensive rats. Methods: Rats were divided into 4 groups (n=29):n=7) and L-NNA+ISO+CAPE (L-NNA+ISO + caffeic acid phenethyl ester) group (n=6). ISO (150 mg/kg/day) was given intraperitoneally (i.p.) once a day for 2 consecutive days (at the 12 th and 13 th days of L-NNA treatment). NG-Nitro-L-arginine (L-NNA) was given orally (25 mg/kg/ day) in drinking water for 14 days. CAPE (10 μmol/kg/day) was given (i.p.) for 7 days after the first week. Systolic blood pressure (SBP) was evaluated by the tail-cuff method and biochemical analysis were performed using an autoanalyzer and a spectrophotometer. Results: SBP in all L-NNA-treated groups was found to be increased at seventh day. AST and LDH levels in LNNA+ISO group were significantly increased compared to control (AST: 125±5 vs. 105±2; LDH: 861±154 vs. 571±46 U/L respectively) (p<0.05). Also, ISO caused to extensive necrosis and mononuclear cell infiltration in hypertensive rat myocardium. CAPE application reversed the enhanced AST and LDH levels as well as the extensive necrosis and the mononuclear cell infiltration in LNNA+ISO+CAPE group compared LNNA+ISO. Conclusion: According to our findings, it might be suggested that CAPE may be a favorable agent to protect the hypertensive myocardium from the injury induced by isoproterenol via mechanisms such as the induction of the antioxidant enzymes and the inhibition of lipid peroxidation.

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The effect of caffeic acid phenethyl ester on ischemia-reperfusion injury in comparison with α -tocopherol in rat kidneys

Cited by 111 publications

References 0 publications

The Protective Effects of Melatonin and Vitamin E against Renal Ischemia-Reperfusion Injury in Rats

The Protective Effects of Melatonin and Vitamin E against Renal Ischemia-Reperfusion Injury in Rats

Prevention of renal ischemia/reperfusion‐induced injury in rats by leflunomide

The effect of caffeic acid phenethyl ester on isoproterenol-induced myocardial injury in hypertensive rats

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