The effect of bovine lactoferrin and lactoferricin B on the ability of feline calicivirus (a norovirus surrogate) and poliovirus to infect cell cultures

McCann, Kaitlyn; Lee, A.; Wan, Jason; Roginski, H.; Coventry, M.J.

doi:10.1046/j.1365-2672.2003.02071.x

Cited by 79 publications

(59 citation statements)

References 34 publications

(50 reference statements)

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“…The spectra of viruses that are affected comprise primarily enveloped RNA and DNA viruses, with the exception of nonenveloped adenovirus (15,102), feline calicivirus (164), and echovirus 6 (199). The antiviral activity of antimicrobial peptides often appears to be related to the viral adsorption and entry process (16) or is a result of a direct effect on the viral envelope (1,208).…”

Section: Antiviral Activitymentioning

confidence: 99%

Peptide Antimicrobial Agents

2006

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SUMMARY Antimicrobial host defense peptides are produced by all complex organisms as well as some microbes and have diverse and complex antimicrobial activities. Collectively these peptides demonstrate a broad range of antiviral and antibacterial activities and modes of action, and it is important to distinguish between direct microbicidal and indirect activities against such pathogens. The structural requirements of peptides for antiviral and antibacterial activities are evaluated in light of the diverse set of primary and secondary structures described for host defense peptides. Peptides with antifungal and antiparasitic activities are discussed in less detail, although the broad-spectrum activities of such peptides indicate that they are important host defense molecules. Knowledge regarding the relationship between peptide structure and function as well as their mechanism of action is being applied in the design of antimicrobial peptide variants as potential novel therapeutic agents.

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Section: Antiviral Activitymentioning

confidence: 99%

Peptide Antimicrobial Agents

2006

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“…Regardless of their precise mode of action, the activities of antibacterial peptides are dependent on interaction with the bacterial cell membrane, in which the first step involves an electrostatic attraction between the cationic peptide and negatively charged components present on the outer bacterial envelope. Cationic AMPs have also demonstrated an ability to confer protection against viral infections caused by a wide spectrum of viruses, including enveloped RNA and DNA viruses, feline calicivirus, and echovirus [3,41,43,65,85]. Some antiviral peptides act by targeting the viral envelope directly.…”

Section: Antimicrobial Agentsmentioning

confidence: 99%

Multifunctional cationic host defence peptides and their clinical applications

Yeung

Gellatly

Hancock

2011

Cell. Mol. Life Sci.

523

496

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With the rapid rise in the emergence of bacterial strains resistant to multiple classes of antimicrobial agents, there is an urgent need to develop novel antimicrobial therapies to combat these pathogens. Cationic host defence peptides (HDPs) and synthetic derivatives termed innate defence regulators (IDRs) represent a promising alternative approach in the treatment of microbial-related diseases. Cationic HDPs (also termed antimicrobial peptides) have emerged from their origins as nature's antibiotics and are widely distributed in organisms from insects to plants to mammals and non-mammalian vertebrates. Although their original and primary function was proposed to be direct antimicrobial activity against bacteria, fungi, parasites and/or viruses, cationic HDPs are becoming increasingly recognized as multifunctional mediators, with both antimicrobial activity and diverse immunomodulatory properties. Here we provide an overview of the antimicrobial and immunomodulatory activities of cationic HDPs, and discuss their potential application as beneficial therapeutics in overcoming infectious diseases.

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“…The effect of lactoferrin on other viral enteritis organisms has not been fully evaluated. There are data showing that lactoferrin interferes with feline calicivirus infection by blocking viral attachment in vitro [16]. However, there are no data evaluating the effect of lactoferrin on the human enteric caliciviruses (sopoviruses or noroviruses).…”

Section: Effect Of Lactoferrin On Enteric Virusesmentioning

confidence: 99%

Effect of lactoferrin on enteric pathogens

Ochoa

Cleary²

2009

Biochimie

114

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Much has been learned in recent years about the mechanisms by which breastfeeding improves child health and survival. However, there has been little progress in using these insights to improve pediatric care. Factors that are important for protecting the breast fed infant might be expected to decrease the adverse effects of weaning on diarrhea, growth, and development. Lactoferrin, an ironbinding protein with multiple physiological functions (anti-microbial, anti-inflammatory, and immunomodulatory), is one of the most important proteins present in mammalian milk. Protection against gastroenteritis is the most likely biologically relevant activity of lactoferrin. Multiple in vitro and animal studies have shown a protective effect of lactoferrin on infections with enteric microorganisms, including rotavirus, Giardia, Shigella, Salmonella and the diarrheagenic Escherichia coli. Lactoferrin has two major effects on enteric pathogens: it inhibits growth and it impairs function of surface expressed virulence factors thereby decreasing their ability to adhere or to invade mammalian cells. Thus, lactoferrin may protect infants from gastrointestinal infection by preventing the attachment by enteropathogens in the gut. Recently several clinical trials in children have started to address this issue. Whether lactoferrin can prevent a significant portion of diarrheal disease remains to be determined.

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The effect of bovine lactoferrin and lactoferricin B on the ability of feline calicivirus (a norovirus surrogate) and poliovirus to infect cell cultures

Cited by 79 publications

References 34 publications

Peptide Antimicrobial Agents

Peptide Antimicrobial Agents

Multifunctional cationic host defence peptides and their clinical applications

Effect of lactoferrin on enteric pathogens

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