The Effect of Bone Marrow Transplantation on Oocyte-Granulosa Cell Interaction and Follicular Development of Cisplatin-Induced Ovarian Failure in Rat

Hendarto, Hendi; Komarhadi, Mohammad Ferry; Darmawanti, Erva; Widjiati, Widjiati; Suhatno,

doi:10.4172/2157-7633.1000133

Cited by 6 publications

(3 citation statements)

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“…Also, anti‐apoptotic growth factors were suggested to explain how MSCs repair chemotherapy damaged ovaries. Such factors include two crucial growth factors that play a role in the interaction of oocyte and granulosa cells, namely Growth Differentiation Factor‐9 (GDF‐9) derived from oocyte and Kit‐Ligand (KL) produced from granulosa cells (Hendarto et al, ).…”

Section: Discussionmentioning

confidence: 99%

The effect of bone marrow-derived mesenchymal stem cells on chemotherapy induced ovarian failure in albino rats

Gabr

Rateb

Sissy

et al. 2016

Microsc. Res. Tech.

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Section: Discussionmentioning

confidence: 99%

The effect of bone marrow-derived mesenchymal stem cells on chemotherapy induced ovarian failure in albino rats

Gabr

Rateb

Sissy

et al. 2016

Microsc. Res. Tech.

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“…This folliculogenesis repair is the basis for further studies regarding the mechanism of mesenchymal bone marrow stem cells in improving folliculogenesis. 20 A subsequent study by Santoso, who provided rat bone marrow stem cell therapy in polycystic ovary syndrome models to observe folliculogenesis, found that folliculogenesis examination using ovarian Haema-toxillin eosin staining showed folliculogenesis improve-ment in the treatment group, which was characterized by improved follicle formation from the primary to Graafian follicles. 21 This study proves that bone marrow mesenchymal stem cells will be homing towards ovarian follicles damaged by endometriosis and subsequently normalize the somatic environment in the area.…”

Section: Characteristics Of the Samplesmentioning

confidence: 99%

Effect of bone marrow mesenchymal stem cells transplantation on BMP-15 expression and Graafian follicle count in mice model of endometriosis

Parasti

Widjiati

Dwiningsih

2019

MOG

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ABSTRAKObjectives: To determine the effect of bone marrow mesenchymal stem cells (BMSCs) on BMP-15 expression and Graafian follicle count in endometriosis mice. Material and Methods: This study was a laboratory randomized clinical trial on Mus musculus. The object of the study was 42 mice which were divided into 3 groups, the control, endometriosis, and endometriosis + BMSCs groups. Comparison of BMP-15 expression and Graafian follicle count between groups was evaluated. Results: Immunohistochemical analysis showed that BMP-15 expression in control, endometriosis, and endometriosis + BMSCs groups had p=0.551, p=0.446 and p=0.917 with ANOVA test p=0.273, indicating no statistically significant differences between groups . Graafian follicular count in the three groups had p=0.31, p=0.001, and p=0.006, with the Kruskal-Wallis test p=0.001. Graafian follicles in the endometriosis + BMSCs group were higher than those in control and endometriosis groups. Conclusion: In the endometriosis mouse model with bone marrow stem cell transplantation the BMP-15 expression in each group did not show a difference, but a significant difference was found in the number of Graafian follicles.

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“…BMSC reduced apoptosis through down regulated the mRNA expression of Bax and p21 and up regulated c-myc mRNA expression in granulosa cells [9] . Our study in cisplatin-induced ovarian failure in rat revealed that bone marrow transplantation may improve oocyte-granulosa cell interaction and follicular development through improvement of kit-ligand and GDF-9 expression [10] . Based on previous studies we can try to use stem cell therapy on this enigmatic disease, of course further research are needed.…”

Section: Introductionmentioning

confidence: 99%

Thinking Out Loud On Endometriosis And Stem Cell Relationship

Hendarto¹

2016

JSRB

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The Effect of Bone Marrow Transplantation on Oocyte-Granulosa Cell Interaction and Follicular Development of Cisplatin-Induced Ovarian Failure in Rat

Cited by 6 publications

References 0 publications

The effect of bone marrow-derived mesenchymal stem cells on chemotherapy induced ovarian failure in albino rats

The effect of bone marrow-derived mesenchymal stem cells on chemotherapy induced ovarian failure in albino rats

Effect of bone marrow mesenchymal stem cells transplantation on BMP-15 expression and Graafian follicle count in mice model of endometriosis

Thinking Out Loud On Endometriosis And Stem Cell Relationship

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