The effect of Bilineaster “Cotoneaster” on reducing bilirubin in neonates with jaundice -a triple-blind randomized clinical trial

Aghababaeian, Hamidreza; Nirouzad, Fereidon; Kiarsi, Maryam; Amirgholami, Neda; Kalani, Leila; Beiranvand, Reza; Moghaddam, Ali Sadeghi; Zakeri, Omid; Majidipour, Narges

doi:10.51847/qabgskl

Cited by 5 publications

(2 citation statements)

References 14 publications

(23 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The level of bilirubin was checked every 24 hours for 72 hours after the initiation of treatment. The aforementioned study showed a significant difference in TSB between the two groups at 48 and 72 hours after the initiation of treatment (43).…”

Section: Herbal Agents For Treatment Of Neonatal Jaundicementioning

confidence: 82%

Recent Advances in Adjuvant Pharmacotherapy for Neonatal Indirect Hyperbilirubinemia: A Narrative Review

Nouri

Zarkesh

2023

J Compr Ped

View full text Add to dashboard Cite

Context: Hyperbilirubinemia is a common cause for diagnostic work-up and therapeutic intervention in neonates and needs a convenient, quick, and safe treatment modality. Phototherapy is the most common treatment for neonatal jaundice; however, complementary treatment is still needed. Despite the identification of the enzymatic pathways of bilirubin catabolism, few pharmacological interventions have been found to be effective in reducing bilirubin, along with traditional phototherapy. This review was conducted to evaluate recent pharmacotherapies as adjuvants to phototherapy for the treatment of neonatal indirect hyperbilirubinemia (IHB). Evidence Acquisition: This study was carried out through a literature search with the keywords of Infant, Newborn, and Indirect Hyperbilirubinemia, combined with Drug Therapy, in PubMed, Scopus, International Statistical Institute, Web of Science, Cochrane, and Embase databases. This study included relevant articles (i.e., randomized controlled trials, observational studies, guidelines, and reviews) written in English and published between 2012 - 2022. Results: This narrative review first assessed the relevant articles to define IHB and its etiology. Then, the efficacy and side effects of recent pharmacologic agents as adjuvants to phototherapy were discussed. Additionally, this study reviewed the efficacy and safety of drugs prescribed to neonates to prevent jaundice. Conclusions: The best drug for adjuvant pharmacotherapy, in addition to phototherapy, for neonatal jaundice has not still been identified. The use of probiotics, prebiotics, synbiotics, and ursodeoxycholic acid (UDCA) in adjuvant to phototherapy has been recently increasing, and beneficial results were observed in most studies. The use of agar, charcoal, fibrate, and phenobarbital had a minor therapeutic role in recent years. There were conflicting results about the efficacy of herbal agents in neonatal jaundice. The use of intravenous immunoglobulin (IVIG), metalloporphyrin, and albumin is also limited to severe or immune-related IHB cases. The prescription of the aforementioned drugs sometimes had different results. Therefore, further research in this regard is necessary.

show abstract

Section: Herbal Agents For Treatment Of Neonatal Jaundicementioning

confidence: 82%

Recent Advances in Adjuvant Pharmacotherapy for Neonatal Indirect Hyperbilirubinemia: A Narrative Review

Nouri

Zarkesh

2023

J Compr Ped

View full text Add to dashboard Cite

show abstract

“…Their metaanalysis showed the positive effect of Cotoneaster manna on the treatment of neonatal jaundice. 28 Fakhri et al, assessed the preventive effect of purgative manna on neonatal jaundice. Cotoneaster (Shire Khesht) is most popular in Persian medicine.…”

Section: Discussionmentioning

confidence: 99%

The Mechanism of Action of Cotoneaster Manna, an Iranian Herbal Medicine, in the Treatment of Neonatal Jaundice

Neamatzadeh,

Ekraminasab,

Bahrami

et al. 2023

WJPN

View full text Add to dashboard Cite

Background: Neonatal jaundice is a common clinical problem caused by the deposition of bilirubin in the tissue. Natural products have long been used to treat jaundice, and Iranian medicine can be a good source of natural treatments for this purpose. In this study, we investigate the mechanism of the effect of Cotoneaster, an Iranian herbal medicine, in the treatment of jaundice in neonates. Methods: We investigated every article that evaluated Purgative manna, Cotoneaster manna, or Cotoneaster in the treatment of neonatal jaundice. We searched the databases of PubMed, Scopus, Web of Sciences, SciELO, CNKI, and Google Scholar for English articles, and a search was also done in Persian in Magiran and Scientific Information Database (SID) published until August 2023. Results: The exact mechanism of Cotoneaster in reducing jaundice is not known, but the following mechanisms have been suggested. The most common mechanisms include increased urination, increased bile excretion from the liver, and increased defecation, as well as neutralizing the effects of oxidative agents and free radicals. Conclusion: Considering that most studies have stated that Cotoneaster combined with phototherapy is effective in treating jaundice and herbal medicines alone cannot treat jaundice. Therefore, identifying the mechanism of Cotoneaster in reducing jaundice can lead to the creation of methods to strengthen its effect. More detailed biochemical and pharmacological studies are needed to understand the mechanism of action of Cotoneaster in reducing neonatal jaundice.

show abstract

Ethnobotany, Phytochemistry and Medicinal Properties of Plants Contain Manna in Iran

Ayati,

Azizi,

Amiri

et al. 2024

Sustainable Landscape Planning and Natural Resources Management

View full text Add to dashboard Cite

The effect of Bilineaster “Cotoneaster” on reducing bilirubin in neonates with jaundice -a triple-blind randomized clinical trial

Cited by 5 publications

References 14 publications

Recent Advances in Adjuvant Pharmacotherapy for Neonatal Indirect Hyperbilirubinemia: A Narrative Review

Recent Advances in Adjuvant Pharmacotherapy for Neonatal Indirect Hyperbilirubinemia: A Narrative Review

The Mechanism of Action of Cotoneaster Manna, an Iranian Herbal Medicine, in the Treatment of Neonatal Jaundice

Ethnobotany, Phytochemistry and Medicinal Properties of Plants Contain Manna in Iran

Contact Info

Product

Resources

About