The Effect of Bilateral Adrenalectomy on Induced Benign Prostatic Hyperplasia in Mice

Fingerhut, B; Veenema, Ralph J.

doi:10.1016/s0022-5347(17)63070-2

Cited by 12 publications

(5 citation statements)

References 5 publications

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“…Comparison of the 3-and 6-month assessments suggested that a longer period of treatment was unlikely to be more effective. Fingerhut and Veenema (1968) used a similar dose in their studies and found improvement after 6 weeks of treatment.…”

Section: Discussionmentioning

confidence: 96%

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A double-blind, controlled, clinical trial of spironolactone for benign prostatic hypertrophy

Castro

Griffiths

Edwards³

1971

Journal of British Surgery

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Section: Discussionmentioning

confidence: 96%

“…Spironolactone may be useful in the treatment of benign prostatic hypertrophy (Fingerhut and Veenema, 1967), and uncontrolled clinical studies suggest that it is useful in 60-65 per cent of patients (Fingerhut and Veenema, 1968).…”

mentioning

confidence: 99%

A double-blind, controlled, clinical trial of spironolactone for benign prostatic hypertrophy

Castro

Griffiths

Edwards³

1971

Journal of British Surgery

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“…Although dog and man develop similar in the elderly age benign prostatic enlargement, they are different by means of clinical and histological differentia tion (5,10). Similar reservations apply to studies on rodents where attempts have been made to produce BPH by administration of estrogens and various metabolites of testos terone (8). Considerable interest has been generated recently by De Klerk et al (7) that benign prostatic enlargement can be induced in the dog by long-term administration of 5a-dihydrotestosterone, 5a-androstane-3a-l7/3-diol in intact animals and of 5a-dihydrotestosterone, 5a-androstane-3a-l 7/3-diol in combination with 17/3-estradiol in castrated animals.…”

Section: Introductionmentioning

confidence: 98%

Comparative Light and Electron Microscopic Study of the Human, Dog and Rat Prostate

Bartsch

Rohr²

1980

Urol Int

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Stereology was shown in several studies to be a relevant method to study the quantitative amount of tissue and cell compartments of normal and pathological altered prostatic tissue. A morphological comparison of the rat (ventral lobe), dog and human prostate was performed by quantitative morphology. In comparing the light microscopic analysis of the rat ventral prostatic lobe with that of the dog prostate, the volumetric amount of the glandular cells in the dog prostate is two times greater than in the rat (ventral prostatic lobe). In the normal human prostate the volumetric amount of the glandular part was calculated to be 55% of the outer part, respectively 45% in the inner part of the prostate. Regarding the stromal tissue, there is no difference between the dog and the normal human prostate, but a striking difference compared to the rat ventral prostatic lobe, where stromal development seems to be sparse (25%). The quantitative measurements of spontaneous dog and human prostatic hyperplasia show that the dog hyperplasia is primarily a glandular disease whereas human benign prostatic hypeφlasia reflects more stromal activation. As shown by the electron microscopic measurements in the normal human and dog prostate, there is a similar great volumetric amount of secretory granules. In comparing the data of the rough endoplasmic reticulum, in the rat there is a higher amount than in the normal human and dog prostate. Conversely, the amount of secretory granules is higher in the dog and human prostate than in the rat (ventral prostatic lobe).

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“…Recently a new compound, estramustine phosphate (Estracyt)2 has been tested and may be efficacious in advanced disease [95][96][97][98]. Various surgical ablation proce dures to reduce androgen levels have been tested [99][100][101]. Analysis of DNA and RNA polymerase, as keys to rates of cell metabolism and protein synthesis, and degradation patterns of administered hormones have been done to elucidate the role of hormones in prostatic activity [102][103][104][105][106], An extensive review and discussion of new data indicating that cyproterone can block specific DNA synthesis during the Gi phase was presented [107].…”

Section: Hormonal Studiesmentioning

confidence: 99%

A Status Report – Human Prostatic Carcinoma, with Emphasis on Potential for Viral Etiology

Rf¹,

Sk²,

Js³

et al. 1977

Oncology

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Several parameters of the biology of cancer of the prostate have been reviewed with a continuing assessment of the possible etiologic role of virus. These aspects include epidemiology, clinical studies, morphology, pathology, enzymology, immunology, endocrinology, model animal studies, in vitro systems, and viral investigations. From available literature it is concluded that, to date, the association with several urogenital tissues of herpes-type viruses has been best documented. It is suggested that a fundamental barrier to more sophisticated virologic and biologic studies is the lack of long term cell cultures of normal and pathologic prostate epithelium from males of all ages.

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The Effect of Bilateral Adrenalectomy on Induced Benign Prostatic Hyperplasia in Mice

Cited by 12 publications

References 5 publications

A double-blind, controlled, clinical trial of spironolactone for benign prostatic hypertrophy

A double-blind, controlled, clinical trial of spironolactone for benign prostatic hypertrophy

Comparative Light and Electron Microscopic Study of the Human, Dog and Rat Prostate

A Status Report – Human Prostatic Carcinoma, with Emphasis on Potential for Viral Etiology

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