Comparative Light and Electron Microscopic Study of the Human, Dog and Rat Prostate

Bartsch, Georg; Rohr, H.P.

doi:10.1159/000280309

Cited by 27 publications

(14 citation statements)

References 10 publications

(17 reference statements)

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“…James and Heywood noted that 10% (5/48) of dogs aged 7 years had testicular tumors at necropsy, with only two of the tumors evident macroscopically. l 1 We saw no age-related statistically significant difference in the serum testosterone levels. Berry et al also saw no aging effect on testosterone values.2 Brendler et al noted a gradual, 35% decrease in serum testos-terone levels in dogs up to 9 years of age.''…”

Section: Discussionmentioning

confidence: 60%

Age-related Changes in the Prostate and Testes of the Beagle Dog

et al. 1990

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Abstract. Age-related changes in the histologic morphology of the Beagle dog prostate have been used as a model for similar changes that occur in human beings. Previous studies of the aging changes in Beagle dogs have been limited to animals less than 10 years of age. In this study, the prostate, testes, and serum testosterone levels were evaluated in healthy Beagle dogs that were grouped by age to provide five groups of dogs that ranged from 3 to 14 years of age. Tissue sections from the prostate and testes were examined qualitatively and quantitatively by light microscopy. All animals 6 years of age and older had histologic characteristics of complex benign prostatic hyperplasia. A mean statistically significant increase in prostatic weight with increased age was noted (mean value 1.08 f 0.22 g/kg body weight at 3 years of age, increasing to 2.64 k 0.37 g/kg body weight at 14 years of age). Morphometric analysis of the prostatic tissue suggested that similar to the change observed in human males, the increase in size was primarily due to an increase in the absolute volume of interstitial tissues (mean value 2.8 k 1.1 cm3 at 3 years of age, increasing to 7.4 k 1.3 cm3 at 14 years of age). The epithelial component did not contribute to the increase noted, with the exception that the percentage of glandular lumen did increase with age, indicating progressive cystic dilatation of the glands. Stereologic analysis of the testes showed a decrease in the relative percentage of germ cells with increasing age (mean value 58.5 k 2.3% at 3 years of age, decreasing to 45.2 k 4.0% at 14 years of age). No distinct age-related trend was detected in serum testosterone concentrations. These findings indicate that the progression of benign prostatic hyperplasia occurs throughout the entire life span of the dog; an association with changes in the testes was not identified.

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Section: Discussionmentioning

confidence: 60%

Age-related Changes in the Prostate and Testes of the Beagle Dog

et al. 1990

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“…). Unlike what occur in men where the phenomenon reflects more stromal activation in the transition zone (Bartsch and Rohr ) in dog, the pathology involves the epithelial and stromal component of the entire gland with consequent overall increase in the volume and weight of the organ (Brendler et al. ; Lowseth et al.…”

Section: Introductionmentioning

confidence: 99%

Power and PulsedDoppler Evaluation of Prostatic Artery Blood Flow in Normal and Benign Prostatic Hyperplasia–Affected Dogs

Zelli¹,

Orlandi²,

Troisi³

et al. 2013

Reprod Domestic Animals

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This study was carried out with the objectives to test the differences in the haemodynamic characteristics of the prostatic artery in normal and benign prostatic hyperplasia (BPH)-affected dogs using Doppler ultrasonography. In sixteen male German shepherd dogs, prostatic volume was detected and prostatic biopsy was performed. The prostatic artery blood flow parameters determined were as follows: peak systolic velocity (PSV), end diastolic velocity (EDV), Resistive Index (RI) and Pulsatility Index. The power Doppler mode was used for colour flow mapping of the prostatic artery. In PW mode at marginal locations, the waveforms recorded showed a continuous pattern typical of the high-resistance vessels, while in subcapsular locations, the waveforms recorded were continuous characteristic of the low-resistance vessel. Peak systolic velocity and EDV in both locations were significantly higher in BPH group (p < 0.001) than normal group (p < 0.05). Pixel number in BPH group in both locations was significantly higher (p < 0.05) compared to the normal group. This study shows that Doppler ultrasonography represents a valid and non-invasive method for the characterization of the blood flow in the prostatic artery in dogs affected with BPH. Moreover, statistically significant differences of blood flow velocities in prostatic artery in normal and BPH-affected dogs were detected. The RI was not able to differentiate normal dogs from dogs affected by BPH and therefore is not a parameter usable for diagnostic purposes, while Power Doppler could represent an additional diagnostic tool.

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“…The rat prostate is divided into distinct ventral, dorsal and lateral lobe pairs (VP, DP, LP) according to relative position to urine bladder. [1]. Human prostate reveals lobes only in early development.…”

Section: Introductionmentioning

confidence: 99%

“…There also is visible unequal proportion epithelium/connective tissue between rodents 5/1 and human 1/1. [1] The function of prostate gland is mainly regulated by androgens. These steroid hormones are responsible for growth, proliferation and inhibit death (survival) of epithelial cells [5].…”

Section: Introductionmentioning

confidence: 99%

Morphological and immunohistochemical comparison of three rat prostate lobes (lateral, dorsal and ventral) in experimental hyperprolactinemia.

Słuczanowska-Głąbowska

Wylot²,

Głąbowski³

et al. 2010

Folia Histochem Cytobiol.

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Abstract:The prolactin plays an important role in the regulation of growth and differentiation of prostate gland besides androgens. The goal of this study was to reveal the influence of elevated prolactin concentration on epithelial cells of prostate. We compared the morphology of epithelial cells of prostate dorsal, lateral and ventral lobes and expression of androgen receptors in these cells in rats with hyperprolactinemia and in control rats. We used sexually mature male Wistar rats. The experimental rats received metoclopramide; the control group received saline in the same way. The prostate dorsal, lateral and ventral lobes were collected routinely for light and electron microscopy. The intensity of immunohistochemical reaction of androgen receptor in epithelial cells of dorsal, lateral and ventral lobes was evaluated by measure of optical density with computer image analysis. The light and electron (transmission and scanning) microscopes were used for morphological observations. Results: In experimental rats twofold increase in prolactin and twofold decrease in testosterone found. In experimental group the expression of androgen receptor was lower in columnar epithelial cells of dorsal and ventral lobes but higher in lateral one. We observed morphological abnormalities in columnar epithelial cells of lateral and dorsal lobes. The columnar epithelial cells of ventral lobes didn't show any morphological changes in hyperprolactinemia.

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Comparative Light and Electron Microscopic Study of the Human, Dog and Rat Prostate

Cited by 27 publications

References 10 publications

Age-related Changes in the Prostate and Testes of the Beagle Dog

Age-related Changes in the Prostate and Testes of the Beagle Dog

Power and PulsedDoppler Evaluation of Prostatic Artery Blood Flow in Normal and Benign Prostatic Hyperplasia–Affected Dogs

Morphological and immunohistochemical comparison of three rat prostate lobes (lateral, dorsal and ventral) in experimental hyperprolactinemia.

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