The Effect of Betamethasone on Neonatal Neutrophil Chemotaxis

Fuenfer, Michael M.; Herson, Victor; Raye, John R.; Woronick, Charles L.; Eisenfeld, Leonard; Ingardia, Charles J.; Block, Charlotte; Krause, Peter J.

doi:10.1203/00006450-198708000-00009

Cited by 22 publications

(16 citation statements)

References 12 publications

(14 reference statements)

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“…The reduced chemotactic activity in these infants could, therefore, be related to a steroid effect, similar to that observed in preterm infants after exogenous steroid administration [3]. However, this hypothesis is not supported by our data, because of the lack of significant correlation between endogenous blood cortisol levels and chemotaxis.…”

Section: Discussioncontrasting

confidence: 70%

Neutrophil chemotaxis in infants delivered by caesarean section

et al. 1991

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We evaluated polymorphonuclear leucocyte (PMN) chemotaxis and cortisol levels in cord blood from 15 healthy term infants delivered by caesarean section and from 15 healthy vaginally delivered term infants. Mean neutrophil chemotaxis was significantly higher in infants delivered by caesarean section (78.3 +/- 23.4 microns) than in vaginally delivered infants (57.8 +/- 16.6 microns; P = 0.01). Mean blood cortisol level was significantly lower in infants delivered by caesarean section (9.14 +/- 2.76 micrograms/dl) than in infants born by vaginal delivery (20.71 +/- 6.98 P = 0.0001). No relationship was found between PMN chemotaxis and blood cortisol level. The higher neutrophil chemotactic activity observed in infants delivered by caesarean section could be related to general maternal anaesthesia.

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Section: Discussioncontrasting

confidence: 70%

Neutrophil chemotaxis in infants delivered by caesarean section

et al. 1991

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“…Several deficits in immune function have been reported after maternal corticosteroid treatment, such as decreased neutrophil chemotaxis (28) and decreased absolute numbers and proliferation of fetal lymphocytes with a reduced production of IL-2 (12,29). This effect was not limited to the fetus but affected maternal lymphocytes as well (29).…”

Section: Discussionmentioning

confidence: 96%

Antenatal Betamethasone Changes Cord Blood Monocyte Responses to Endotoxin in Preterm Lambs

et al. 2004

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“…Con cerning adults, there are discordant litera ture data: from migration inhibition, re ferred to most frequently [2,3,[5][6][7], to mi gration stimulation [3] or absence of GC effect [4,5,7], In our study, MP in vitro, in doses near to physiological and pharmaco logical concentrations, did not affect the ran dom migration of adult cells, but stimulated it in young ones. And while in the literature support for MP ineffectiveness in adults ex ists [4,5,7], there seem to be no data avail able on GC action on the Mcp random migra tion in early postnatal life. Recently, Fucnfer et al [30] reported that betamethasone re duced neonatal neutrophil chemotaxis but had no effect on the motility of adult human neutrophils.…”

Section: Discussionmentioning

confidence: 73%

“…And while in the literature support for MP ineffectiveness in adults ex ists [4,5,7], there seem to be no data avail able on GC action on the Mcp random migra tion in early postnatal life. Recently, Fucnfer et al [30] reported that betamethasone re duced neonatal neutrophil chemotaxis but had no effect on the motility of adult human neutrophils. But, comparing their and our results in youngs, the opposite GC influence on migration was observed.…”

Section: Discussionmentioning

confidence: 99%

“…The alteration in the recirculation pathway of leukocytes has been suggested to be a predominant factor in this effect [1], In vitro studies suggest that the disturbance of peripheral leukocyte number can, in part, be a consequence of GC action on cell migra tion. Thus, it has been showed that human monocyte chemotaxis [2], human eosinophil and neutrophil chemotaxis [3,4], rat T and B lymphocyte random and directed migration [5], and rat and guinea pig peritoneal Mip random migration [6,7] can be affected by GC. These data refer to cells obtained from adult humans or animals.…”

Section: Introductionmentioning

confidence: 99%

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Impaired Random Migration and Special Reactivity to Methylprednisolone in Young Guinea Pig Macrophages

L¹,

Vilić²

1990

Neonatology

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Macrophage (Mφ) migration ability and its susceptibility to methylprednisolone (MP) action, both in vivo and in vitro, were compared in young and adult guinea pigs. The random migration of oil-induced peritoneal Mφ was tested by the capillary tube method. The obersvation of Mφ locomotion from 4 to 44 h of incubation showed that cells obtained from young animals had a smaller migration ability than those of adults. Besides that, differences in reactivity to MP were observed between the compared groups. The application of MP in vivo led to the stimulation of young Mφ migration in vitro, but inhibited adult Mφ migration. The exposure of adult Mφ to MP in vitro did not affect their motility, but migration of the young Mφ, as previously, was stimulated. Thus, the presented findings report about the immaturity of young Mφ random migration and its special reactivity to MP.

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The Effect of Betamethasone on Neonatal Neutrophil Chemotaxis

Cited by 22 publications

References 12 publications

Neutrophil chemotaxis in infants delivered by caesarean section

Neutrophil chemotaxis in infants delivered by caesarean section

Antenatal Betamethasone Changes Cord Blood Monocyte Responses to Endotoxin in Preterm Lambs

Impaired Random Migration and Special Reactivity to Methylprednisolone in Young Guinea Pig Macrophages

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