Psychological and physical problems often occur in hemodialysis patients such as anxiety, sleep quality and fatigue which if not treated immediately, can reduce the patient's quality of life. Benson relaxation and deep breathing can lower anxiety, sleep quality, and fatigue in hemodialysis patients. With decreased anxiety, higher sleep quality and decreased fatigue, the patient's quality of life could be enhanced. This study aims to determine the differences in anxiety, sleep quality and fatigue in hemodialysis patients treated using the Benson relaxation technique and deep breathing. The research method used quasi-experimental on several 52 respondents who were selected through the simple random sampling technique and were divided into 2 intervention and control groups. The Kruskal-walis test showed that the p-value = 0.000 <0.05 was obtained in anxiety. The difference rank value is higher in the Benson relaxation of 37.96. on sleep quality, p-value = 0.000 <0.05. The rank difference is higher in the Benson relaxation of 34.56. At the same time, the data management results on fatigue obtained a p-value = 0.014 <0.05. The difference in Rank value is higher in the Benson relaxation of 34.56. It can be concluded that Benson's relaxation therapy can reduce anxiety, sleep quality, and fatigue because it uses spiritual values that can improve the quality of life of hemodialysis patients.