The Effect of Bemegride (Megimide) and Metrazol on Some Neurodepressors

Clinical pharmacology of systemic antidotes

“…Bemegride is thought most closely to resemble pentylenetetrazol pharmacologically. 66,238,470 In man, bemegride produces electroencephalographic changes similar to those produced by pentylenetetrazol 169 and in animals the convulsant effects of bemegride are facilitated by reserpine (as is the case with pentylenetetrazol). 66 The analeptic dose-response curve for bemegride is essentially identical with that for pentylenetetrazol.…”