Clinical pharmacology of systemic antidotes

Done, Alan K.

doi:10.1002/cpt196126750

Cited by 17 publications

(3 citation statements)

References 55 publications

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“…The main aim of treatment is to remove the cyanide from the ferric ions (Chen et al, 1934;Rose, 1952, 1956;Done, 1961;Lovatt Evans, 1964;Goodman and Gilman, 1970). This has traditionally been achieved by the rapid intravenous administration of sodium nitrite followed by sodium thiosulphate.…”

Section: Discussionmentioning

confidence: 99%

The use of dicobalt edetate (Kelocyanor) in cyanide poisoning

Hillman¹,

Bardhan²,

Bain³

1974

Postgraduate Medical Journal

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Section: Discussionmentioning

confidence: 99%

The use of dicobalt edetate (Kelocyanor) in cyanide poisoning

Hillman¹,

Bardhan²,

Bain³

1974

Postgraduate Medical Journal

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“…Little more can be said at this point about methods for its use and its undesirable effects than was documented earlier. 4,45,48,79,135,185 Some newer points °Ciba Pharmaceutical Products, Inc., Summit, N. J. of interest have appeared in the more recent literature. Two pregnancies occurred in a patient with Wilson's disease treated with dimercaprol.…”

Section: Pharmacology Of the Available Chelating Drugsmentioning

confidence: 99%

Clinical uses of metal‐binding drugs

Chenoweth

1968

Clin Pharma and Therapeutics

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To summarize the current position of metal-chelating drugs in medicine Biochemical Research Laboratory, The Dow Chemical CompanyThe metal-binding or chelating drugs have a special interest to pharmacologists because these compounds represent the unique example of "designed drugs." However, apart from the fact that their fundamental mechanism of action is usually exactly as planned, they present to the clinician almost all of the kinds of problems found in the use of any other drug. To the pharmacologist, they often present a puzzle in that some of their useful as well as some unwanted side effects seem unrelated to their metal-binding actions.The interactions of metal-binding compounds with essential metals and toxic metals obviously relate to all pharmacological science, in its broadest definition. ~ OThe literature on this subject is unusually intractable because of its age, scope~ size, and internationality. A MEDLARS literature search by tbe National Library of Medicine covering only January, 1964~ through 11arch, 1967, returned 296 citations, nearly all of which were directly pertinent (Search No. 011173). In order to write a useful review it has been necessary to restrict the literature quoted to the most recent reports, largely in English, and to hew close to the clinical line.Several previous reviews and monographs on various biological and medical aspects of chelation may be consulted. 24 , 28, 107, 184, 210,239 Valuable reviews concerning metalinduced intoxications and the use of chelating agents in their treatment also exist. 2 , 18, 23, 48, (;2, 132, 195 The practical use of the formation of a slightly dissociated metal salt of an organic compound is actually very old in medicine. A familiar in vitro example is shown in Fig.

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“…There appears to be no lack of awareness of the so-called "systemic antidotes," such as dimercaprol (BAL), calcium disodium edetate (CaN a 2 EDT A), and pyridine aldoxime methiodide (2-P AM) . 15 Because these more or less specific chemical antagonists represent important triumphs of modem scientific medicine, it is appropriate that they are widely appreciated. Unfortunately, the number of such antidotes is limited.…”

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Trends in the therapy of acute poisonings

Gosselin

Smith

1966

Clin Pharma and Therapeutics

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Attention has been focused on many new and old techniques for preventing and treating poisonings arising from the ingestion of substances against which no specific antidotes are established. Aside from symptomatic and general supportive care, the nonspecific measures of value in clinical toxicology are of two types: those employed to minimize absorption by terminating the toxic exposure and those designed to promote the excretion of poisons already absorbed. In the first category, the induction of emesis, gastric lavage, the ingestion of adsorbents, and the administration of cathartics are recognized. In the second category are techniques for accelerating renal and biliary excretion, as well as extracorporeal hemodialysis, peritoneal dialysis, gastric dialysis, and related procedures. Considerably more information is desirable about each of these measures, how and when it should he used, and what advantages and disadvantages can be anticipated in its adoption. On the basis of recent studies, specific topics of promise for future investigation are suggested. Developments in these areas will probably prove to be more important than new systemic antidotes in terms of improving patient care in clinical toxicology.

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Clinical pharmacology of systemic antidotes

Cited by 17 publications

References 55 publications

The use of dicobalt edetate (Kelocyanor) in cyanide poisoning

The use of dicobalt edetate (Kelocyanor) in cyanide poisoning

Clinical uses of metal‐binding drugs

Trends in the therapy of acute poisonings

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