The effect of bee prepolis on primary dysmenorrhea: a randomized clinical trial

Abstract

ObjectivePrimary dysmenorrhea typically occurs with no associated pelvic pathology and is common in adolescents and young women. This study evaluated the effect of bee propolis on relief of primary dysmenorrhea.MethodsThe study was performed in 2018 in Hamadan, in western Iran, among female students with primary dysmenorrhea. Participants were randomly divided into two groups, using balanced block randomization, and were administered a placebo or bee propolis capsules for 5 days during two menstruation cycles. The number of participants required was estimated to be 86 in total, with 43 students in each group according to the inclusion criteria. We used the visual analog scale to assess pain severity. The independent t-test was conducted for comparing between two groups, using SPSS 16.0.ResultsA significant change was found in the mean pain scores during the first (P<0.001) and second (P<0.001) months after using bee propolis in comparison with placebo. The means of the pain scores in the bee propolis group were 5.32±2.28 and 4.74±2.40 in first and second months after the intervention, respectively, whereas the means of the pain scores in the placebo group were 7.40±1.21 and 7.17±1.24 in first and second months after the intervention, respectively.ConclusionOur study showed that the use of bee propolis for two months compared with placebo reduced primary dysmenorrhea during the first and second months after use, with no adverse effects. Therefore, it could be used as an alternative to nonsteroidal anti-inflammatory drugs for relief of primary dysmenorrhea.

The Effect of Oral Chamomile on Anxiety: A Systematic Review of Clinical Trials

“…Table 1 shows the extract of the included studies [ 18 20 22 44 45 46 47 48 49 50 ]. This systematic review is based on 10 clinical trials.…”

“…The first randomized clinical trial regarding this subject took place in the United States [ 18 ], and four subsequent studies in the U.S. examined the long-term effectiveness of chamomile use or its efficacy in diagnosed subjects [ 20 44 45 46 ]. One study was conducted in Indonesia [ 47 ], and four were performed in Iran [ 22 48 49 50 ]. The studies spanned from 2009 to 2022.…”

Latest reports of primary dysmenorrhea

“…The studies of E. Jenabi et al on 86 young women showed that taking bee propolis for 5 days during two menstrual cycles significantly reduced pain, both after the first and the second month, without side effects [16]. This substance contains isoflavones, which belong to the group of polyphenols and have antiviral, antibacterial and anti-inflammatory properties.…”

Pengaruh Madu Terhadap Tingkat Nyeri Dismenore Dan Kualitas Hidup Mahasiswi Fakultas Kedokteran Universitas Pembangunan Nasional Veteran Jakarta

“…14 Pada penelitian uji klinis menggunakan bee propolis menunjukkan bahwa bee propolis yang diminum mulai dua hari sebelum menstruasi hingga hari ketiga menstruasi (total 5 hari) dapat mengurangi dismenore primer. 15 18 Brief Pain Inventory (BPI) digunakan untuk menilai kualitas hidup subjek dalam bentuk gangguan akibat nyeri dismenore terhadap aktivitas umum, mood, kemampuan berjalan, pekerjaan, hubungan dengan orang lain, tidur, dan menikmati hidup menggunakan skala 0-10, sebagai berikut: 0 = tidak mengganggu dan 10 = mengganggu. 19…”

“…Pada penelitian pengaruh pemberian bee propolis terhadap dismenore primer, bee propolis diberikan dalam dua siklus menstruasi. 15 Pada penelitian lainnya tentang pengaruh pemberian ekstrak Prasaplai terhadap kualitas hidup, ekstrak tersebut diberikan dalam enam siklus menstruasi. 33 Oleh karena itu, penelitian ini memiliki keterbatasan yaitu tidak dapat mengetahui efek pemberian madu dalam jangka panjang atau membandingkan efek pemberian madu pada siklus pertama, siklus kedua dan seterusnya.…”