The Effect of Baseline Lesion Mineral Loss on in situ Remineralization

Abstract

The effect of baseline lesion mineral loss on the remineralization of enamel lesions by a sodium fluoride dentifrice was studied in situ by means of an appliance carrying enamel sections. Artificial lesions of various sizes were created, by means of acidified gelatin, and were then mounted on the appliances of five volunteers. Each brushed twice daily for two min with a 1000 ppm F sodium fluoride dentifrice. Measurements of mineral content were made at baseline and at weekly intervals by microradiographic/microdensitometric techniques. Data from all five volunteers showed a linear increase in remineralization rate with increasing lesion size. Thus, in studies which compare the effects of different remineralizing formulations, care must be taken to ensure that initial lesion sizes are matched, or that the results are expressed as a percentage change in mineral content.

The effect of ozone on progression or regression of artificial caries-like enamel lesions in vitro

“…Generally, conflicting data exist about the parameter "lesion severity" as a determinant for lesion repair. Strang et al 24 showed mineral deposition during in situ remineralisation to be (positively) correlated to the amount of mineral lost during the formation of the lesions. Also, in situ studies have shown that smaller lesions were more prone to demineralisation than larger ones.…”

An approach to normalizing micro-CT depth profiles of mineral density for monitoring enamel remineralization progress

“…The intra oral (in situ) study by Strang et al, demonstrated that the greater the mineral density at SZ and LB before the remineralization, the smaller the increment of mineral density 16) . Although we have proposed the normalization approaches to creating the depth profi les corresponding to mineral density in this study, biases such as beam hardening effect or determination of the surface remain unsolved for the more accurate quantifi cation of the mineral density.…”

Development of New Software as a Convenient Analysis Method for Dental Microradiography

“…Differential analysis 16) was used to detect the minimum gradient point of mineral content profile (Fig. 5), which was essential for the calculations of SZd and LBd 13) . For SZd, it was defined as the depth to the maximum Fig.…”

“…Therefore, the first aim of the present study was to develop a new program to calculate these parameters using Visual Basic for Applications combined with Microsoft Excel 2004 -so that the new program can be used freely and widely by other researchers. In addition, this program was capable of calculating the surface zone depth (SZd), lesion body depth (LBd) 13) , and three other parameters such as outer surface zone (OSZ), inner lesion body (ILB), and the sandwiched area (SA) between OSZ and ILB. The latter three parameters are not included in the commercial program.…”