The Effect of Bariatric Surgery Type on Lipid Profile: An Age, Sex, Body Mass Index and Excess Weight Loss Matched Study

Cunha, Filipe; Oliveira, Joana; Preto, John; Saavedra, Ana; Costa, Marlene; Magalhães, Diogo; Lau, Eva; Bettencourt‐Silva, Rita; Freitas, Paula; Varela, Ana; Carvalho, Davide

doi:10.1007/s11695-015-1825-1

Cited by 54 publications

(30 citation statements)

References 37 publications

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“…In addition to patients' BMI and EBW, breath acetone was correlated with several biochemical makers of nutrition and fat metabolism, including concentrations of high-density lipoprotein, neutrophil count, triglyceride, and glucose. These findings are in agreement with existing evidence documenting changes in lipid and glucose metabolism that are associated with obesity and weight loss [2,[22][23][24][25]. Multivariate linear regression revealed that a model incorporating neutrophil count, acetone, low-density lipoprotein and glucose, could predict 41% of the variance in EBW.…”

Section: Discussionsupporting

confidence: 90%

“…Multivariate linear regression revealed that a model incorporating neutrophil count, acetone, low-density lipoprotein and glucose, could predict 41% of the variance in EBW. The association of raised neutrophil count, low-density lipoprotein, and glucose with increased BMI/ EBW is well established in the literature [2,22,24]. In the setting of obesity, increased numbers of white blood cells, including neutrophils, are thought to reflect the proinflammatory characteristics associated with this condition and its related comorbidities [24,26].…”

Section: Discussionmentioning

confidence: 98%

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Variation in Exhaled Acetone and Other Ketones in Patients Undergoing Bariatric Surgery: a Prospective Cross-sectional Study

et al. 2018

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 98%

Variation in Exhaled Acetone and Other Ketones in Patients Undergoing Bariatric Surgery: a Prospective Cross-sectional Study

et al. 2018

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“…Therefore, it would be advisable to supplement the diet with pyridoxal phosphate, a cofactor of transaminases, and orotic acid, which lowers the concentration of lipoproteins containing apo B. Various reports in the literature concerning lipid profile in bariatric patients indicate that the stabilization of lipid profile occurs after 12 months [6]. There are also reports showing on its significant improvement 2 years after the surgery in 92.3 % of patients and unchanged level of HDL [19].…”

Section: Discussionmentioning

confidence: 99%

Body Weight Reduction and Biochemical Parameters of the Patients After RYGB and SG Bariatric Procedures in 12-Month Observation

et al. 2016

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BackgroundThe aim of this study was to evaluate the effect of sleeve gastrectomy (SG) and Roux-en-Y-bypass (RYGB) on anthropometric and biochemical parameters, including changes in glucose levels, lipid profile and liver function. Drastic decrease in all lipid fractions a few weeks or months after the surgery could be regarded as favourable, but low level of HDL is an independent risk factor for heart diseases. Extreme load on the liver without preparation of the patient to the surgery can have negative consequences.MethodsThe test group comprised of 40 female patients at the age of 42.96 with average body weight of 131.56 kg and BMI 46.49. Biochemical analyses were performed using calorimetric method.ResultsNo statistically significant differences were observed in glucose levels between the two types of procedures. The highest differences were noted for triglycerides levels, which decreased, as well as all cholesterol fractions, after RYGB, but were increasing during the first months after SG procedure. Changes in lipid profile, caused by the reduction of all lipid fractions, were more visible after RYGB. The decrease in total cholesterol directly and activity of liver enzymes after the procedure was as higher after RYGB as after SG. Increased activity of transaminases indicates significant liver overload.ConclusionsWith the selection of groups of patients with similar initial parameters, it is not clear whether the differences between the two procedures when assessing the improvement of glycaemia are significant. However, due to invasive character of RYGB, liver overload lasting several months and lifelong limited absorption of nutrients, the possibility of SG procedure should be considered as a first option.

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“… 10 , 11 RYGB is a combined malabsorptive and restrictive procedure and it has been shown to induce reductions in serum triglycerides, cholesterol and cholesteryl esters. 12 , 13 , 14 When compared with conventional treatment of obesity, bariatric surgery leads to greater long-term weight loss, higher remission of metabolic syndrome and type 2 diabetes, and decrease in cardiovascular risk. 10 , 15 It is still unclear to what extent the effects of RYGB are related to changes in endogenous metabolism, weight loss or changes in the diet.…”

Section: Introductionmentioning

confidence: 99%

Alterations in fatty acid metabolism in response to obesity surgery combined with dietary counseling

et al. 2017

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Background:The effects of obesity surgery on serum and adipose tissue fatty acid (FA) profile and FA metabolism may modify the risk of obesity-related diseases.Methods:We measured serum (n=122) and adipose tissue (n=24) FA composition and adipose tissue mRNA expression of genes regulating FA metabolism (n=100) in participants of the Kuopio Obesity Surgery Study (KOBS, age 47.2±8.7 years, BMI 44.6±6.0, 40 men, 82 women) before and one year after obesity surgery. As part of the surgery protocol, all the subjects were instructed to add sources of unsaturated fatty acids, such as rapeseed oil and fatty fish, into their diet. The results were compared with changes in serum FA composition in 122 subjects from the Finnish Diabetes Prevention study (DPS) (age 54.3±7.1 years, BMI 32.2±4.6, 28 men, 94 women).Results:The proportion of saturated FAs decreased and the proportion of n-3 and n-6 FAs increased in serum triglycerides after obesity surgery (all P<0.002). Weight loss predicted changes in quantitative amounts of saturated FAs, monounsaturated FAs, n-3 and n-6 FAs in triglycerides (P<0.002 for all). Moreover, the changes in adipose tissue FAs reflected the changes in serum FAs, and some of the changes were associated with mRNA expression of elongases and desaturases in adipose tissue (all P<0.05). In line with this the estimated activity of elongase (18:1 n-7/16:1 n-7) increased significantly after obesity surgery in all lipid fractions (all P<4 × 10−7) and the increase in the estimated activity of D5D in triglycerides was associated with higher weight loss (r=0.415, P<2 × 10−6). Changes in serum FA profile were similar after obesity surgery and lifestyle intervention, except for the change in the absolute amounts of n-3 FAs between the two studies (P=0.044).Conclusions:Beneficial changes in serum and adipose tissue FAs after obesity surgery could be associated with changes in endogenous metabolism and diet.

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The Effect of Bariatric Surgery Type on Lipid Profile: An Age, Sex, Body Mass Index and Excess Weight Loss Matched Study

Abstract: RYGB is the only bariatric surgery that reduces TC and LDL in age-, sex-, BMI- and EWL-matched patients. All three procedures improved TG and HDL similarly when the confounding effect of weight loss is eliminated.

Cited by 54 publications

References 37 publications

Variation in Exhaled Acetone and Other Ketones in Patients Undergoing Bariatric Surgery: a Prospective Cross-sectional Study

Variation in Exhaled Acetone and Other Ketones in Patients Undergoing Bariatric Surgery: a Prospective Cross-sectional Study

Body Weight Reduction and Biochemical Parameters of the Patients After RYGB and SG Bariatric Procedures in 12-Month Observation

Alterations in fatty acid metabolism in response to obesity surgery combined with dietary counseling

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