The Effect of Avocado to the Profile of Blood Urea Nitrogen (BUN) and Creatinine in Rats (Rattus norvegicus) Induced with Meloxicam

Abstract

Incidence of drug overdose during treatment of acute disease consequently leads to serious renal damage. As supporting treatment, administration of herbal medicine and food dietary are frequently developed. This research aimed to prove how the administration of avocado juice could lower the BUN and creatinine level in white rats induced with toxic doses of meloxicam. Meloxicam is a non-steroidal anti-inflamatory drug (NSAID), which is effectively used as an anti-inflamatory, analgesic, and antipyretic. Twenty four (24) male Wistar rats were assigned to 4 groups of six rats each (n=6). 1 ml of CMC 1% was administered to Control Group I, 30 mg/kgBB meloxicam and 1 ml of CMC 1% to Control Grup II, 30 mg/kgBB meloxicam and avocado juice 5 g/kgBB/day to Treatment Group I, and 30 mg/kgBB meloxicam and avocado juice 10 g/kgBB/day to Treatment Group II. The study was conducted over 8 days, then the level of Blood Urea Nitrogen and creatinine of the white rats were examined on the 1st and 8th day. The results were analyzed by Anova Two Way With Replication, then followed by T-test (α = 0,05) if there were difference. The Anova Two Way With Replication test showed that the mean of the four groups either the levels of Blood Urea Nitrogen or creatinine was significantly decreased (p<0,05). The decrease of BUN in the treatment group I was 27,17 27,17mg/dl and 17,83mg/dl while the decrease of creatinine level was 0,983mg/dl and 0,713mg/dl. The conclusion of this study was that avocado juice decreases level of Blood Urea Nitrogen and creatinine in white rats which exposed toxic doses of meloxicam.

An insight into the effect of Persea Americana as a potassium rich diet on adenine induced renal fibrosis in mice

“…Addition of avocado decreased creatinine serum concentration showing a superior effect of diet I to diet II as diet I almost normalized creatinine concentration compared to control group. In line with our results, Anshar et al (2018) demonstrated that avocado juice decreases level of blood urea nitrogen and creatinine in white rats exposed to toxic doses of meloxicam [18]. It was observed that mice fed diet I regained weight in contrast to mice fed diet II in which weight reduction continues after adenine administration.…”

Avocado Seeds Relieve Oxidative Stress-Dependent Nephrotoxicity but Enhance Immunosuppression Induced by Cyclosporine in Rats

“…Avocado byproducts (seeds and peels) are a good source of phenolic compounds that can inhibit lipid and protein oxidation [ 53 ]. Avocado flavonoids could prevent the formation of renal calculi by suppressing the release of ROS, thereby protecting renal cells from oxidative stress damage [ 54 ]. Avocado has antioxidant, anti-inflammatory, hypocholesterolemic, and antidiabetic effects [ 55 ].…”

Evaluation of ameliorating role of avocado Persea americana fruit extract against monosodium glutamate-induced toxicity in pregnant female albino rats and their offspring

“…These findings go parallel with the study of Mahadeva et al [38] who reported that avocado fruit acts as a nephroprotective agent. An avocado oil-rich diet has been shown to modify renal functions [39]. The data of the present study revealed that in MSG-exposed mother rats and their offspring the levels of serum sodium ions appeared significantly higher while the level of potassium ions appeared significantly lowered if compared with the control.…”