The effect of autonomous neuropathy on bowel preparation in type 2 diabetes mellitus

Öztürk, Nevin Akçaer; Gokturk, Huseyin Savas; Demir, Mehmet; Erdoğan, Doğan; Unler, Gulhan Kanat; Gür, Gürden; Yılmaz, Uğur

doi:10.1007/s00384-009-0757-4

Cited by 32 publications

(29 citation statements)

References 23 publications

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“…Furthermore, one study indicated that diabetic patients (irrespective of insulin use, diabetic control, or diabetic neuropathy) have a significantly poorer response to a colonoscopy bowel cleansing preparations than do nondiabetic patients (92). A recent study also suggests that optimal bowel preparation was significantly poorer in DM patients with autonomous neuropathy than in DM patients without autonomous neuropathy and controls (93). The diagnostic accuracy of the colonoscopy depends on the quality of the colon cleansing.…”

Section: Discussionmentioning

confidence: 99%

Is Diabetes Mellitus an Independent Risk Factor for Colon Cancer and Rectal Cancer?

Yuhara

Steinmaus

Cohen

et al. 2011

American Journal of Gastroenterology

301

238

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OBJECTIVES Diabetes mellitus (DM) has been associated with an increased risk of colorectal cancer (CRC). The American College of Gastroenterology Guidelines for Colorectal Cancer Screening 2008 recommend that clinicians be aware of an increased CRC risk in patients with smoking and obesity, but do not highlight the increase in CRC risk in patients with DM. To provide an updated quantitative assessment of the association of DM with colon cancer (CC) and rectal cancer (RC), we conducted a meta-analysis of case–control and cohort studies. We also evaluated whether the association varied by sex, and assessed potential confounders including obesity, smoking, and exercise. METHODS We identified studies by searching the EMBASE and MEDLINE databases (from inception through 31 December 2009) and by searching bibliographies of relevant articles. Summary relative risks (RRs) with 95% confidence intervals (CIs) were calculated with fixed- and random-effects models. Several subgroup analyses were performed to explore potential study heterogeneity and bias. RESULTS DM was associated with an increased risk of CC (summary RR 1.38, 95% CI 1.26–1.51; n = 14 studies) and RC (summary RR 1.20, 95% CI 1.09–1.31; n = 12 studies). The association remained when we limited the meta-analysis to studies that either controlled for smoking and obesity, or for smoking, obesity, and physical exercise. DM was associated with an increased risk of CC for both men (summary RR 1.43, 95% CI 1.30–1.57; n = 11 studies) and women (summary RR 1.35, 95% CI 1.14–1.53; n = 10 studies). For RC, there was a significant association between DM and cancer risk for men (summary RR 1.22, 95% CI 1.07–1.40; n = 8 studies), but not for women (summary RR 1.09, 95% CI = 0.99–1.19; n = 8 studies). CONCLUSIONS These data suggest that DM is an independent risk factor for colon and rectal cancer. Although these findings are based on observational epidemiological studies that have inherent limitations due to diagnostic bias and confounding, subgroup analyses confirmed the consistency of our findings across study type and population. This information can inform risk models and specialty society CRC screening guidelines.

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Section: Discussionmentioning

confidence: 99%

Is Diabetes Mellitus an Independent Risk Factor for Colon Cancer and Rectal Cancer?

Yuhara

Steinmaus

Cohen

et al. 2011

American Journal of Gastroenterology

301

238

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“…2 Optimal bowel cleansing is poorer in diabetes patients with autonomous neuropathy than in those without autonomous neuropathy and in controls. 3 It is well known that abdominal discomfort, flatulence, nausea, vomiting, constipation, and diarrhea are more common in diabetes patients than in the general population. 4 The pathogenesis is unclear.…”

Section: Introductionmentioning

confidence: 99%

Orocecal Transit Time and Small Intestinal Bacterial Overgrowth in Type 2 Diabetes Patients from North India

Rana

Bhansali

Bhadada

et al. 2011

Diabetes Technology & Therapeutics

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“…Five studies assessed the influence of high blood pressure on HRV in T2DM compared with healthy controls [49,50,54,55,58]. Other studies compared HRV between T2DM patients and controls based on blood catecholamine levels [44], circadian autonomic rhythm in insulinoresistant subjects [45], in cases of bowel preparation [63], metabolic syndrome [47], circadian rhythm in relation to blood adiponectin [62], or dimethylarginine levels [61], hypoglycaemic episodes [59], in acromegalic patients [53], and inhalation of ultrafine particles [57].…”

Section: Objectives Of Included Articlesmentioning

confidence: 99%

“…In each individual study, exclusion criteria were the same as for T2DM, i.e. pregnancy [43,62], neurological disease [43], BMI over 25 kg/m 2 [42,44,45] or 35 kg/m 2 [58,62], chronic heart [42,44,45,[50][51][52]57,58,[60][61][62][63], liver [56,60,63], or renal [42,42,45,56,58,[60][61][62][63] failure, thyroid disorder [50,52], or treatment that can influence HRV parameters [44][45][46]52,54,[57][58][59][60]. Controls had high blood pressure in five studies [49,56,58,60,62], and were on dialysis in three studies [43,…”

Section: Inclusions and Exclusions Criteriamentioning

confidence: 99%

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Heart rate variability in type 2 diabetes mellitus: A systematic review and meta-analysis

Benichou

Pereira

Mermillod

et al. 2018

Annales d'Endocrinologie

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BackgroundCardiac autonomic neuropathy in type 2 dibetes mellitus (T2DM) patients is frequent and associated with high cardiovascular mortality. Heart rate variability (HRV) is the gold standard to measure cardiac autonomic neuropathy. We aimed to conduct a systematic review and meta-analysis to evaluate the impact of T2DM on HRV parameters. OPEN ACCESS Citation: Benichou T, Pereira B, Mermillod M, Tauveron I, Pfabigan D, Maqdasy S, et al. (2018) Heart rate variability in type 2 diabetes mellitus: A systematic review and meta-analysis. PLoS ONE 13(4): e0195166. https://doi.org/10.-2.13 to -0.91), lower LF (-1.08; -1.46 to -0.69]), and lower HF (-0.79; -1.09 to -0.50). LF/HF did not differ between groups. Levels of blood glucose and HbA1c were associated with several HRV parameters, as well as Time from diagnosis of T2DM ConclusionsT2DM was associated with an overall decrease in the HRV of T2DM patients. Both sympathetic and parasympathetic activity were decreased, which can be explained by the deleterious effects of altered glucose metabolism on HRV, leading to cardiac autonomic neuropathy.

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The effect of autonomous neuropathy on bowel preparation in type 2 diabetes mellitus

Abstract: These data suggest that optimal bowel cleansing is poorer in diabetics with autonomous neuropathy than in those without autonomous neuropathy and controls.

Cited by 32 publications

References 23 publications

Is Diabetes Mellitus an Independent Risk Factor for Colon Cancer and Rectal Cancer?

Is Diabetes Mellitus an Independent Risk Factor for Colon Cancer and Rectal Cancer?

Orocecal Transit Time and Small Intestinal Bacterial Overgrowth in Type 2 Diabetes Patients from North India

Heart rate variability in type 2 diabetes mellitus: A systematic review and meta-analysis

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