Orocecal Transit Time and Small Intestinal Bacterial Overgrowth in Type 2 Diabetes Patients from North India

Rana, Satyavati; Bhansali, Anil; Bhadada, Sanjay Kumar; Sharma, Surendra Kumar; Kaur, Jaspreet; Singh, Kartar

doi:10.1089/dia.2011.0078

Cited by 47 publications

(44 citation statements)

References 19 publications

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“…Investigators have suggested that bacterial overgrowth is important to the clinical findings in patients with IBS [15] and abnormal breath testing has been seen in some patients with IBS [16]. Intestinal stasis and motility patterns are felt to predispose to the development of small intestinal bacterial overgrowth (SIBO) [17,18,19]. We employed breath hydrogen and methane testing to evaluate whether prolonged small bowel transit was associated with positive breath testing.…”

Section: Discussionmentioning

confidence: 99%

Motility Abnormalities in Irritable Bowel Syndrome

et al. 2014

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Background/Aims: The intestinal pathophysiology in irritable bowel syndrome (IBS) is largely unknown. The lactulose breath test has been used to identify small bowel bacterial overgrowth in these patients. Methods: We studied intestinal transit in patients with IBS using of the SmartPill® (SP) wireless pH/pressure recording capsule and performed lactulose breath tests to look for physiologic abnormalities. Results: A total of 35/46 (76%) of the IBS patients had prolonged gastric emptying times. Constipation-predominant disease was associated with prolonged gut transit times. The mean hours ± SD for colonic transit time in the constipation group was 71.7 ± 61.1 (n = 13) compared with 22.5 ± 14.9 (n = 14) for diarrhea-predominant and 26.4 ± 21.5 (n = 20) for mixed clinical subtype (p = 0.0010). No correlation between small bowel transit time and abnormal breath hydrogen or methane excretion in the 46 combined patients with IBS was seen. Conclusions: Delayed gastric emptying was identified in IBS and in some patients may contribute to at least a component of their symptoms. Constipation-predominant IBS is associated with prolonged gut transit times. Otherwise, transit abnormalities do not appear to be important in IBS. Intestinal transit did not correlate with breath test results.

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Section: Discussionmentioning

confidence: 99%

Motility Abnormalities in Irritable Bowel Syndrome

et al. 2014

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“…One study showed that bacterial overgrowth may contribute to the delay of intestinal transit as confirmed by its significant improvement after eradication therapy [49]. Study by Rana et al [50] also observed that OCTT in type 2 diabetes patients with SIBO was significantly delayed (P \ 0.001) compared with type 2 diabetes patients without SIBO and they concluded that SIBO in diabetes patients may be due to delayed OCTT. In type 1 diabetes also there was a statistically significant increase in OCTT values in patients (79 ± 41 min) in comparison with controls (54 ± 17 min) (P = 0.01).…”

Section: Orocecal Transit Time and Hydrogen Breath Testsmentioning

confidence: 95%

Hydrogen Breath Tests in Gastrointestinal Diseases

Rana

Malik

2014

Ind J Clin Biochem

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Hydrogen breath tests are widely used to explore pathophysiology of functional gastrointestinal (GI) disorders. Small intestinal bacterial overgrowth (SIBO) and carbohydrate malabsorption are disorders detected by these tests that have been proposed to be of great importance for symptoms of GI diseases. Glucose hydrogen breath test is more acceptable for diagnosis of SIBO whereas lactose and fructose hydrogen breath tests are used for detection of lactose and fructose maldigestion respectively. Lactulose hydrogen breath test is also used widely to measure the orocecal transit time for GI motility. These methods are noninvasive and inexpensive. Many patients with func-

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“…Moreover, it was demonstrated that type 2 diabetes in family history and IBS were risk factors associated with the occurrence of SIBO. Gastritis proved to be a protective factor [61].…”

Section: Association Between Sibo and Other Nosological Entitiesmentioning

confidence: 96%

“…Impaired intestinal motility precedes manifestation of SIBO, which can be developed in this group of patients due to delayed orocecal transit time (OCTT) [61].…”

Section: Association Between Sibo and Other Nosological Entitiesmentioning

confidence: 99%