The Effect of Aureomycin and Chloramphenicol on the Fungal and Bacterial Flora of Children

Jj, Mcgovern; Rh, Parrott; Cw, Emmons; Ross, S; Fg, Burke; Ec, Rice

doi:10.1056/nejm195303052481001

Cited by 45 publications

(5 citation statements)

References 16 publications

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“…If inflight le flora were reduced to antibiotic therapy was required under these he immediate preflight conditions, the loss of competing bacterial speig an equilibrium shift cies could result in an eventual overgrowth of C. Light environment. 23,27,29,33). was in an environment A set of samples was collected from the Apollo a pressure of one-third 14 astronauts 16 days after their return to earth.…”

Section: Discussionmentioning

confidence: 99%

Changes in the Fungal Autoflora of Apollo Astronauts

Taylor¹,

Henney²,

Ellis³

1973

Applied Microbiology

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Specimens were repeatedly obtained for mycological examination from the skin, throat, urine, and feces of the six astronauts who conducted the Apollo 14 and Apollo 15 lunar exploration missions. Analysis of preflight data demonstrates that the process of severely restricting opportunities from colonization for 3 weeks before flight resulted in a 50% reduction in the number of isolated species. Postflight data indicate that exposure to the space flight environment for up to 2 weeks resulted in an even greater reduction with a relative increase in the potential pathogen Candida albicans. No incidences of microbial shock were observed when crewmembers were quarantined for 16 days after completion of the space flight. Intercrew transfer of particular species could not be demonstrated because most species were not consistently recovered.

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Section: Discussionmentioning

confidence: 99%

Changes in the Fungal Autoflora of Apollo Astronauts

Taylor¹,

Henney²,

Ellis³

1973

Applied Microbiology

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“…include low salivary flow [9][10][11] , low pH 2,12 and wearing a denture. 11,13 The association of smoking and antibiotic intake with oral Candida colonization remains controversial with some studies showing an association, 12,14,15 while others do not support a link. 16,17 Species of Candida other than albicans are less frequently, but consistently, recovered from the oral cavity.…”

Section: Classic Studies On Oral Mycologymentioning

confidence: 99%

Mining the oral mycobiome: Methods, components, and meaning

et al. 2016

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Research on oral fungi has centered on Candida. However, recent internal transcribed spacer (ITS)-based studies revealed a vast number of fungal taxa as potential oral residents. We review DNA-based studies of the oral mycobiome and contrast them with cultivation-based surveys, showing that most genera encountered by cultivation have also been detected molecularly. Some taxa such as Malassezia, however, appear in high prevalence and abundance in molecular studies but have not been cultivated. Important technical and bioinformatic challenges to ITS-based oral mycobiome studies are discussed. These include optimization of sample lysis, variability in length of ITS amplicons, high intra-species ITS sequence variability, high inter-species variability in ITS copy number and challenges in nomenclature and maintenance of curated reference databases. Molecular surveys are powerful first steps to characterize the oral mycobiome but further research is needed to unravel which fungi detected by DNA are true oral residents and what role they play in oral homeostasis.

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“…A number of studies have indicated that Candida can be isolated from the oral cavity with greater prevalence and in greater numbers during tetracycline therapy (McGoven et al, 1953). Animal studies have shown that suppression of the commensal oral flora by diets containing broad spectrum antimicrobials (e.g., tetracyclines) are a prerequisite to initiate and establish oral infection (Fisker et al, 1982), although other studies indicate that antibiotics are not essential for initiation of oral candidosis in murine models (Allen and Beck, 1983).…”

Section: Oral Microfloramentioning

confidence: 99%

Candida and Oral Candidosis: A Review

Scully

Elkabir

Samaranayake

1994

Critical Reviews in Oral Biology & Medicine

311

245

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Candida species are the most common fungal pathogens isolated from the oral cavity. Their oral existence both as a commensal and an opportunist pathogen has intrigued clinicians and scientists for many decades, and recent investigations have revealed many attributes of this fungus contributing to its pathogenicity. In addition, the advent of the human immunodeficiency virus infection and AIDS has resulted in a resurgence of oral Candida infections. Clinicians are witnessing not only classic forms of the diseases but also newer clinical variants such as erythematous candidosis, rarely described hithertofore. Therefore, this review is an attempt at detailing the current knowledge on Candida and oral candidoses together with the newer therapeutic regimes employed in treating these mycoses.

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The Effect of Aureomycin and Chloramphenicol on the Fungal and Bacterial Flora of Children

Cited by 45 publications

References 16 publications

Changes in the Fungal Autoflora of Apollo Astronauts

Changes in the Fungal Autoflora of Apollo Astronauts

Mining the oral mycobiome: Methods, components, and meaning

Candida and Oral Candidosis: A Review

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