The effect of arsenic on some antioxidant enzyme activities and lipid peroxidation in various tissues of mirror carp (Cyprinus carpio carpio)

Abstract

The effect of arsenic bioaccumulation in liver, kidney, skin, muscle, and intestinal tissues of mirror carp (Cyprinus carpio carpio) was investigated on lipid peroxidation and certain antioxidant enzyme activities. In this study, three aquarium groups were formed from mirror carp: control group, 0.5-, and 1-mg/L arsenic concentrations. The fish were dissected after 1 month. Arsenic bioaccumulation, malondialdehyde (MDA) levels, catalase (CAT), and superoxide dismutase (SOD) enzyme activities were determined in the tissues. Results showed that arsenic was accumulated in liver, kidney, muscle, skin, and intestinal tissues. As the final product of lipid peroxidation, MDA levels were determined to have increased in all tissues with the exception of muscle. On the other hand, CAT and SOD enzyme activities in the fish tissues were decreased as compared to the control group. In the muscle tissue, differences were observed in the enzyme activities depending on arsenic concentration. Considering the increases in enzyme inhibition and MDA levels, liver was observed to be the main tissue affected in response to the arsenic toxicity.

Bioaccumulation of metallic trace elements and antioxidant enzyme activities in Apfelbeckia insculpta (L. Koch, 1867) (Diplopoda: Callipodida) from the cave Hadži-Prodanova Pećina (Serbia)

“…Despite the fact that a statistically significant difference between genders in favour of females was obtained only for GR and GST activities ( Figs. 2A and B), the validity of our findings is supported by the results of previous authors, who reported decrease of SOD (Zaman et al, 1995;Wang et al, 2006;Altikat et al, 2015), CAT (Wang et al, 2006;Altikat et al, 2015) and GPX, GR, and GST (Wang et al, 2006) activities after exposure to As.…”

Catechin Attenuates the Effect of Combined Arsenic and Deltamethrin Toxicity by Abrogation of Oxidative Stress and Inflammation in Wistar Rats

“…In this study, co-exposure to As and DM resulted in the inhibition of all the antioxidant enzyme activities measured except in the testis, where the toxicants caused an increase in CAT activity. Inhibition of antioxidant enzyme activity has been reported following exposure of animals to either As or DM [33][34][35][36]. The observed decrease in SOD, CAT and GPx activities may be due to oxidative inactivation of the proteins arising through the damaging effect of free radicals generated by both As and DM.…”

Short-term exposure of arsenite disrupted thyroid endocrine system and altered gene transcription in the HPT axis in zebrafish

“…Mat es (2000) demonstrated that oxidative damage occurs when the physiological antioxidant protection fails to counteract the elevated ROS levels. Altikat et al (2014) reported that after exposing to 1 mg L À1 AsIII for 15 d, the MDA levels in Carp livers (Cyprinus carpio) increased from 4.1 to 5.7 nmol mg À1 protein. In our study, compared with control group, MDA levels showed no significant difference in AsIII 4.2 treatment (Fig.…”