The Effect of Antacid on Aspirin Pharmacokinetics in Healthy Thai Volunteers

Itthipanichpong, Chandhanee; Sirivongs, Prayuth; Wittayalertpunya, S.; Chaiyos, N

doi:10.1515/dmdi.1992.10.3.213

Cited by 6 publications

(3 citation statements)

References 9 publications

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“…One hundred twenty‐one APAP concentrations (Achterbergh et al, 2019; Baraka et al, 1990; Garcia Aguirre et al, 2019; Grattan et al, 2000; Raffa et al, 2018; Seideman, 1991; Singla et al, 2012; Volak et al, 2013; Yin et al, 2001), 145 FLB concentrations (Greenblatt et al, 2006; Hanley et al, 2013; Liu et al, 2009; Ozbay et al, 2009; Qayyum et al, 2011; Szpunar et al, 1987; Taburet et al, 1995), 124 ASP concentrations (Angiolillo et al, 2020; Benedek et al, 1995; Cryer et al, 1999; Hobl et al, 2015; Husted et al, 1983; Itthipanichpong et al, 1992; Koch et al, 1978; Misawa et al, 1985; Muir et al, 1997; Nakayasu et al, 2003), and 306 IBP concentrations (Al‐Meshal et al, 1994; De Brabander et al, 2004; Dewland et al, 2009; Gillespie et al, 1982; Hammami et al, 2017; Hattrem et al, 2018; Idkaidek & Arafat, 2011; Kapil et al, 2004; Kimura et al, 1992; Koenigsknecht et al, 2017; Laneury et al, 1998; Lapatto‐Reiniluoto et al, 1999; Neuvonen, 1991; Shin et al, 2017; Sugár et al, 2019) were extracted from 11 groups of APAP data, 11 groups of FLB data, 14 groups of ASP data, and 22 groups of IBP data. Demographics and study details are summarized in Table S1, and the line charts of plasma concentration–time after doses are shown in Figure S1.…”

Section: Resultsmentioning

confidence: 99%

Rapid identification of potential nonsteroidal anti‐inflammatory drug overdose–induced liver toxicity and prediction of follow‐up exposure: Integrating bioanalytical and population pharmacokinetic assay

Zhou,

Zhao,

Wang

et al. 2024

Biomedical Chromatography

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Nonsteroidal anti‐inflammatory drugs (NSAIDs) are among the most frequently used drugs that can cause liver toxicity. The aim of this study was to integrate bioanalytical and population pharmacokinetic (PopPK) assay to rapidly screen and quantify the concentrations of NSAIDs in plasma and monitor clinical safety. A liquid chromatography–tandem mass spectrometry (LC–MS/MS) method was developed for the simultaneous quantification of acetaminophen (APAP), flurbiprofen (FLB), aspirin (ASP), and ibuprofen (IBP), four commonly used NSAIDs. The PopPK model of the signature toxicant was analyzed based on the published literature. The LC–MS/MS method was successfully validated and applied to determine NSAID concentrations in patient plasma samples. APAP, ASP, and IBP data were best fitted using a one‐compartment model, and FLB data were best fitted using a two‐compartment model. Bootstrapping and visual predictive checks suggested that a robust and reliable pharmacokinetic model was developed. A fast, simple, and sensitive LC–MS/MS method was developed and validated for determining APAP, FLB, ASP, and IBP in human plasma. Combined with the PopPK model, this method was applied to rapidly analyze the concentrations of NSAIDs in clinical samples from patients presenting to the emergency department with acute liver dysfunction and monitored NSAIDs clinical safety.

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Section: Resultsmentioning

confidence: 99%

Rapid identification of potential nonsteroidal anti‐inflammatory drug overdose–induced liver toxicity and prediction of follow‐up exposure: Integrating bioanalytical and population pharmacokinetic assay

Zhou,

Zhao,

Wang

et al. 2024

Biomedical Chromatography

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“…Finally, when the preventive analgesia strategy is used with a single drug or under a multimodal approach, the maximum plasma concentration must be taken into account, so that the drug has its greatest presence in the blood and can reach the target immediately in the bed. surgical [ 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 ]. In the case of multimodal analgesia using a combination of drugs, it must be taken into account that at least one of the drugs used is at its maximum plasma concentration at the time of incision [ 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 ].…”

Section: Discussionmentioning

confidence: 99%

“…surgical [ 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 ]. In the case of multimodal analgesia using a combination of drugs, it must be taken into account that at least one of the drugs used is at its maximum plasma concentration at the time of incision [ 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 ].…”

Section: Discussionmentioning

confidence: 99%

Analgesic Efficacy of COX-2 Inhibitors in Periodontal Surgery: A Systematic Review and Meta-Analysis

et al. 2023

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The objective of this systematic review and meta-analysis was to evaluate the analgesic efficacy of COX-2 inhibitors versus other drugs in periodontal surgery. Two researchers searched PubMed, Google Scholar, ACM Digital, BASE, EBSCOhost, Scopus, or Web of Science for clinical trials using various combinations of words. All articles that met the selection criteria were assessed using the Cochrane Collaboration’s risk of bias tool. For data analysis, the inverse variance and mean difference statistical method was used with Review Manager 5.3 software for Windows. According to the conclusion of each study (qualitative evaluation), only one clinical trial had results in favor of a COX-2 inhibitor when compared to placebo, one clinical study informed that a COX-2 was better that an active control, four studies showed similar analgesic efficacy to active controls, and one clinical study informed the analgesic effect of one celecoxib-caffeine combination in comparison with celecoxib alone and placebo (n = 337). The COX-2 inhibitors showed a decrease in the rescue analgesic consumption (n = 138; I2 = 15%; mean difference = −0.31; 95%CIs = −0.6 to −0.01), and lower pain intensity at four hours (n = 178; I2 = 0%; mean difference = −2.25; 95%CIs = −2.94 to −1.55; p = 0.00001) when compared to active controls after periodontal surgery. In conclusion, the data indicate that COX-2 agents produce better pain relief in comparison to placebo and other drugs after periodontal surgery.

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Determination and characterization of the interaction between magaldrate antacid and some drugs: Part II

Gohary

1995

Pharmaceutica Acta Helvetiae

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The Effect of Antacid on Aspirin Pharmacokinetics in Healthy Thai Volunteers

Cited by 6 publications

References 9 publications

Rapid identification of potential nonsteroidal anti‐inflammatory drug overdose–induced liver toxicity and prediction of follow‐up exposure: Integrating bioanalytical and population pharmacokinetic assay

Rapid identification of potential nonsteroidal anti‐inflammatory drug overdose–induced liver toxicity and prediction of follow‐up exposure: Integrating bioanalytical and population pharmacokinetic assay

Analgesic Efficacy of COX-2 Inhibitors in Periodontal Surgery: A Systematic Review and Meta-Analysis

Determination and characterization of the interaction between magaldrate antacid and some drugs: Part II

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