The Effect of Angipars on Diabetic Neuropathy in STZ-Induced Diabetic Male Rats: A Study on Behavioral, Electrophysiological, Sciatic Histological and Ultrastructural Indices

Abstract

Diabetes mellitus is the most common metabolic disease with a high prevalence rate in human society that eventually leads to the peripheral nervous system complications in a great number of patients. In the present study, the effects of Angipars on nerve conduction velocity, histological alterations, and behavioral indices were investigated. Diabetes was induced in male rats by intraperitoneal injection of streptozotocin (STZ). Six weeks after STZ injection, animals were divided into five groups control, vehicle, and 3 experimental groups. The vehicle group received 1 mL distilled water daily for two weeks and three experimental groups received, respectively, intraperitoneal injection of 5, 10, and 20 mg/kg Angipars daily for two weeks. Intraperitoneal injection of Angipars, in some extent, could significantly improve behavioral indices of the experimental groups as compared to the vehicle group. Furthermore, mean nerve conduction velocity in the vehicle group showed significant difference with that in the control and the 2nd experimental groups; therefore, Angipars could increase nerve conduction velocity in neuropathic rats. Overall, Angipars exerted positive effects on the treatment and reduction of physiologic symptoms and improvement of sciatic morphological injuries in neuropathic rats.

An Update On Rodent Model Studies In Diabetic Neuropathy: A Brief Communication

“…It is a chronic metabolic disorder that leads to long-term complications affecting some sites such as heart, kidney, retina, vessels and peripheral nerves. [4,5,10] Peripheral neuropathy is one of the common complications of diabetes which in turn increases the risk of other diabetes complications such as foot ulcers and amputation. [6,7,10] Almost more than half of diabetic patients suffer from different forms of neuropathy after passing 1-2 decades of their diseases.…”

“…[4,5,10] Peripheral neuropathy is one of the common complications of diabetes which in turn increases the risk of other diabetes complications such as foot ulcers and amputation. [6,7,10] Almost more than half of diabetic patients suffer from different forms of neuropathy after passing 1-2 decades of their diseases. [8,10] Abnormalities of polyol pathway and defects of protein kinase C metabolism which cause nerve demyelination have also been described in diabetic peripheral neuropathy.…”

“…[6,7,10] Almost more than half of diabetic patients suffer from different forms of neuropathy after passing 1-2 decades of their diseases. [8,10] Abnormalities of polyol pathway and defects of protein kinase C metabolism which cause nerve demyelination have also been described in diabetic peripheral neuropathy. [9,10] Based on these mechanisms of injury, various prevention and treatment strategies have been already suggested and are under investigation.…”

“…[8,10] Abnormalities of polyol pathway and defects of protein kinase C metabolism which cause nerve demyelination have also been described in diabetic peripheral neuropathy. [9,10] Based on these mechanisms of injury, various prevention and treatment strategies have been already suggested and are under investigation. [10] As mentioned before, peripheral neuropathies are a major cause of morbidity in patients with diabetes mellitus, affecting as many as 50% of patients with diabetes.…”

“…[9,10] Based on these mechanisms of injury, various prevention and treatment strategies have been already suggested and are under investigation. [10] As mentioned before, peripheral neuropathies are a major cause of morbidity in patients with diabetes mellitus, affecting as many as 50% of patients with diabetes. [12,14] They can cause acute and chronic neuropathic pain, hyperalgesia and impaired nerve conduction velocities, which can cause significant morbidity of these patients and affect their daily activities.…”