The effect of angiotensin II receptor antagonists on kidney function in two-kidney, two-clip Goldblatt hypertensive rats

Drug interactions, renal impairment and hypoglycaemia in a patient with Type II diabetes

“…The interaction of ACE inhibitors with NSAIDs is a class effect insofar as it concerns reduced angiotensin II activity [7]. It is likely that angiotensin II receptor antagonists, such as losartan, would interact in the same way; animal models of renal artery stenosis support this assumption [10], although no human data are as yet available.…”

Renal oxidative stress and renal CD8+ T-cell infiltration in mercuric chloride-induced nephropathy in rats: role of angiotensin II

“…Rats in Groups I, II and III were to be injected subcutaneously with a single 500 ml dose (2.5 mg/kg) of HgCl 2 (99.5% purity; Sigma, St. Louis, MO) in normal (0.9%) saline. Rats in Groups II and IV were to be treated daily by gastric gavage with 30 mg Losartan/kg (Cozaar, Merck & Co., Whitehouse Station, NJ) in normal saline (Abdi & Johns 1997). Rats in Groups III and V were to be treated daily by gavage with 30 mg Enalapril/kg (Renitec, Merck & Co.) in normal saline (Guo et al 2008).…”

“…Ang II acts through two receptor subtypes, AT1 and AT2 receptors. Most of the classic physiological effects of Ang II are mediated by the AT1 receptor, including induction of oxidative stress (Abdi & Johns 1997;Garrido & Griendling 2009;Benigni et al 2010). In addition, increased production of Ang II by the effect of Ang I-converting enzyme (ACE) is related to enhanced Ang II-related actions (Abdi & Johns 1997;Benigni et al 2010).…”

“…With the advent of drugs such as Losartan that specifically blocks the Ang II AT-1 receptor and Enalapril that blocks ACE activity, it is possible to dissect the physiological roles of the renin-angiotensin system (Abdi & Johns 1997;Donmez et al 2002;Benigni et al 2010;Muñoz et al 2011;Peña et al, 2013). Therefore, the aim of this study was to determine the role of Ang II in the renal oxidative stress and CD8 cell infiltration in rats treated with HgCl 2 using the angiotensin II receptor (AT-1) blocker Losartan and the ACE inhibitor Enalapril.…”

Pro-inflammatory role of angiotensin II in mercuric chloride-induced nephropathy in rats

“…Rats in the Losartan (Cozaar, Merck & Co., Whitehouse Station, NJ) group received this antagonist of AT-1 receptors (angiotensin II receptor type-1) at 30 mg Losartan/kg BW daily by gastric gavage (Abdi and Johns, 1997). Rats in the Enalapril (Renitec, Merck) group received this inhibitor of angiotensin I converting enzyme at 30 mg Losartan/kg BW daily by gavage (Guo et al, 2008).…”