The effect of anesthetic agents on perioperative bleeding during tonsillectomy: Propofol‐based versus desflurane‐based anesthesia

Okuyucu, Şemsettin; İnanoğlu, Kerem; Akkurt, Cagla; Akoğlu, Ertap; Dagli, Safak

doi:10.1016/j.otohns.2007.10.032

Cited by 4 publications

(3 citation statements)

References 24 publications

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“…[2] Recently, along with the advancement in anesthetic and surgical techniques, tonsillectomy has become safer than old times. [3] The 2 main drugs among many that are widely used for anesthetic purpose are known to be sevoflurane and remifentanil. [4,5] …”

Section: Introductionmentioning

confidence: 99%

Correlation of MDR1 gene polymorphisms with anesthetic effect of sevoflurane–remifentanil following pediatric tonsillectomy

Shi

Zhang²,

Zhang³

et al. 2017

Medicine

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Background:The motive of this study was to investigate the collaboration between MDR1 gene polymorphisms and anesthetic effects following pediatric tonsillectomy.Methods:All together 178 children undergoing tonsillectomy with preoperative sevoflurane–remifentanil anesthesia were selected. In order to determine MDR1 gene polymorphisms of 3435C > T, 1236C > T, and 2677G > T/A, polymerase chain reaction–restriction fragment length polymorphism was used. Mean arterial pressure (MAP), diastolic blood pressure (DBP), systolic blood pressure (SBP), and heart rate (HR) at T0 (5 mins after the repose), T1 (0 min after tracheal intubation), T2 (5 mins after the tracheal intubation), T3 (0 min after the tonsillectomy), T4 (0 min after removal of the mouth-gag) and T5 (5 min after the extubation) were observed. The visual analog scale (VAS), the face, legs, activity, cry, and consolability (FLACC) pain assessment, and Ramsay sedation score were recorded after the patients gained consciousness. The adverse reactions were also observed.Results:As compared to the CT + TT genotype of MDR1 1236C > T, the time of induction, respiration recovery, eye-opening, and extubation of children with the CC genotype was found to be shorter (all P <.05); the MAP, SBP, DBP, and HR were significantly reduced at T5 in children that possessed the CC genotype (all P <.05), the VAS at postoperative 1, 2, 4, and 8 hours and Ramsay sedation score were decreased, while the FLACC score increased (all P <.05). It was found that the adverse reaction rate was lower in children bearing the CC genotype (P <.05).Conclusion:It could be concluded that anesthetic effect in patients with the MDR1 1236C > T CC genotype was found to be superior to those carrying the CT + TT genotype.

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Section: Introductionmentioning

confidence: 99%

Correlation of MDR1 gene polymorphisms with anesthetic effect of sevoflurane–remifentanil following pediatric tonsillectomy

Shi

Zhang²,

Zhang³

et al. 2017

Medicine

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“…Esto se explicaría dado que el propofol tendría un efecto dual: procoagulante mediante la estimulación del efecto de las prostaglandinas y anticoagulante por inhibición de la ciclooxigenasa [27]. En 2008, Okuyucu et al, evaluó el sangrado intraoperatorio según el tipo de mantención de la anestesia general (TIVA propofol vs inhalatoria) determinando un menor sangrado con el uso de propofol [28]. A pesar de los resultados contradictorios, estas diferencias en la técnica anestésica suelen carecer de significado clínico.…”

Section: Discussionunclassified

Sangrado intraoperatorio de amigdalectomía en población pediátrica. Influencia de factores quirúrgicos y anestésicos

Ojeda¹,

Carranza²,

S³

et al. 2020

Rev. chil. anest.

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Introducción: La amigdalectomía con o sin adenoidectomía, es una de las cirugías más frecuente en población pediátrica. Desde hace varios años se ha vuelto una intervención predominantemente ambulatoria, por lo que lograr identificar los factores que influyen en el sangrado intraoperatorio es de suma importancia para prevenir complicaciones postoperatorias y reshospitalización. Material y Método: Se realizó un estudio observacional de corte-transversal. Se incluyó a pacientes entre 1 y 14 años sometidos a amigdalectomía con o sin adenoidectomía entre noviembre de 2015 y mayo de 2017, obteniendo un total de 709 casos evaluados. Se determinó el sangrado intraoperatorio de forma volumétrica. Posteriormente, se realizó un análisis multivariado con un modelo de regresión lineal generalizado. Resultados: Se cuantificó el sangrado intraoperatorio promedio en 1,9 ml/kg (IC 95%; 1,7-2,05). El uso de propofol (aumento del 30% del sangrado) y tiempo quirúrgico (2% por cada incremento de un minuto) fueron factores de riesgo. Mientras que el uso de electro bisturí se asoció con una disminución del 50% en relación al no uso (p = 0,001). Conclusiones: Fueron factores de riesgo para sangrado intraoperatorio el uso de propofol y un tiempo quirúrgico prolongado. El uso de electrobisturí constituyó un factor protector.

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“…The role of anesthetics in bleeding was also examined during tonsillectomy. Okuyucu et al randomized patients undergoing tonsillectomy to either propofol-based anesthesia ( n = 27) or to desflurane-based anesthesia ( n = 33) and demonstrated that propofol-based anesthesia was associated with less measured blood loss [ 11 ]. These studies indicate that an inhalation-based anesthetic technique is associated with more intraoperative bleeding than a propofol-based anesthetic technique for head and neck procedures.…”

Section: Clinical Studiesmentioning

confidence: 99%

The Role of Anesthetic Selection in Perioperative Bleeding

Yuki

DiNardo

Koutsogiannaki

2021

BioMed Research International

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Perioperative bleeding is one of the major comorbidities associated with surgery. While anesthesia is a critical component to perform surgery, a number of clinical studies supported the contribution of anesthetic drugs to perioperative bleeding. Here, we reviewed the literature on this topic including the underlying mechanism and discussed the future direction on coagulation research in anesthesia.

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The effect of anesthetic agents on perioperative bleeding during tonsillectomy: Propofol‐based versus desflurane‐based anesthesia

Abstract: Propofol-based anesthesia is a reliable method for use in children who undergo tonsillectomy.

Cited by 4 publications

References 24 publications

Correlation of MDR1 gene polymorphisms with anesthetic effect of sevoflurane–remifentanil following pediatric tonsillectomy

Correlation of MDR1 gene polymorphisms with anesthetic effect of sevoflurane–remifentanil following pediatric tonsillectomy

Sangrado intraoperatorio de amigdalectomía en población pediátrica. Influencia de factores quirúrgicos y anestésicos

The Role of Anesthetic Selection in Perioperative Bleeding

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